JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 3. P. 26-32
DOI: 10.12737/article_5927e7f0092c62.96839938
Cytogenetic Radiation Dose Indication in about 30 Years after the Accident at the Chernobyl NPP
V.Yu. Nugis, A.Yu. Bushmanov, M.G. Kozlova, O.A. Tikhonova
State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
V.Yu. Nugis - Head of Lab., Dr. Sc. Biol.; A.Yu. Bushmanov - First Deputy Director General, Dr. Sc. Med., Prof.; M.G. Kozlova - Research Worker; O.A. Tykhonova - Head of Lab., PhD Med.
Abstract
Purpose: Retrospective biological dose indication based on cytogenetic examination of essentially liquidators who worked in various years by 29.7-30.4 years after the Chernobyl accident.
Material and methods: The cytogenetic investigation of peripheral blood lymphocyte cultures using the classical method and single-color FISH-staining of chromosomes in parallel.
Results: In general the frequencies of FISH-detected translocations were above background levels in 17 from 56 people. Dose estimates ranged from 172 to 624 mSv. The single highly aberrant cells contained mostly unstable chromosome aberrations were detected by FISH-analysis in 4 examined individuals. The presence or absence of such cells was not associated with the availability of an estimated dose cytogenetically. Analysis of the data obtained by means of a classical method showed that only one liquidator had the general frequency of chromosome rearrangements and frequency of chromosome aberrations - indicators of radiation effects - exceeded background values.
Conclusion: 1. Using single-color FISH-painting of chromosomes in about 28-30 years after the accident at the Chernobyl NPP allows carrying out a retrospective dose assessment for persons involved in the situation.
- In classical painting of chromosomes the individual levels of unstable type aberrations found at the same time did not differ from their baseline values. The amount of abnormal chromosomes in the studied group was also not significantly higher than the control level.
- The detection of single highly aberrant metaphases in peripheral blood lymphocyte cultures of some persons is typical for people who stayed in areas contaminated by the Chernobyl nuclear disaster. It is obviously due to the presence of alpha-emitting radionuclides, although dosimetric interpretation these data remains unclear.
- The correlation between the physical and biological dose estimates was very low although it was statistically significant. Therefore, in our opinion, the accuracy of the Chernobyl documented physical dose estimates is questionable.
Key words: chromosome aberrations, peripheral blood, lymphocytes culture, accidental irradiation, the accident at the Chernobyl NPP
REFERENCES
- Nugis V.Yu., Bushmanov A.Yu., Zapadninskaya E.E. Citogeneticheskie issledovanija cherez 28-29 let posle avarii na Chernobyl’skoj AEHS. Med. radiol. i radiac. bezopasnost’. 2016. Vol. 61. No. 4. P. 35-42. (In Russian).
- Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Vienna: IAEA. 2011. 229 p.
- Nugis V.Yu., Kozlova M.G. Citogeneticheskie issledovaniya v dvuh situaciyah obnaruzheniya nekontroliruemyh istochnikov ioniziruyushchego izlucheniya. Med. radiol. i radiac. bezopasnost’. Vol. 60. No. 2. P. 37-46. (In Russian).
- Lucas J.N., Awa A., Straume T. et al. Rapid translocation frequency analysis in human decades after exposure to ionizing radiation. Int. J. Radiat. Biol. 1992. Vol. 62. No. 1. P. 53-63.
- Mendelsohn M.L., Mayall B.H., Bogart E. et al. DNA content and DNA-based centromeric index of 24 human chromosomes. Science. 1973. Vol. 179. No. 78. P. 1126-1129.
- Snigireva G.P., Bogomazova A.N., Novickaya N.N. i soavt. Biologicheskaya indikaciya radiacionnogo vozdejstviya na organizm cheloveka s ispol’zovaniem citogeneticheskih metodov. Medicinskaya tekhnologiya FS-2007/015-U. Moscow. 2007. 29 p. (In Russian).
- Vorobcova I.E., Semenov A.V. Vozrastnaya dinamika chastoty spontannyh i inducirovannyh in vitro hromosomnyh aberracij v limfocitah krovi cheloveka pri estestvennom i luchevom starenii. Radiac. biologiya. Radioehkologiya. 2010. Vol. 50. No. 3. P. 253-258. (In Russian).
- Sigurdson A.J., Ha M., Hauptmann M. et al. International study of factors affecting human chromosome translocations. Mutat. Res. 2008. Vol. 652. No. 2. P. 112-121.
- Whitehouse C.A., Edwards A.A., Tawn E.J. et al. Translocation yields in peripheral blood lymphocytes from control populations. Int. J. Radiat. Biol. 2005. Vol. 81. No. 2. P. 139-145.
- Bakaeva O.A. Neobhodimost’ ispol’zovaniya popravki Jetsa v kriterii χ2 proverki nezavisimosti kachestvennyh peremennyh. Nauchnye issledovaniya i ih prakticheskoe primenenie. Sovremennoe sostoyanie i puti razvitiya 2012. Cb. nauch. trudov SWorld Mezhdunar. nauchno-prakt. konf. - Odessa: KUPRIENKO. 2012. Vol. 2. Vyp. No. 3. P. 82-83. (In Russian).
- Domracheva E.V., Kuznecov S.A., Shklovskij-Kordi N.E., Vorob’ev A.I. Kletki s mnogochislennymi hromosomnymi aberraciyami, obnaruzhennye u zhitelej Chernobyl’skogo regiona. Gematologiya i transfuziologiya. 1991. Vol. 36. No. 11. P. 36-37. (In Russian).
- Domracheva E.V., Rivkind N.B., Aseeva E.A. et al. Stable and unstable aberrations in lymphocytes of Chernobyl accident clearance workers carrying rogue cells. Appl. Radiat. and Isotopes. 2000. Vol. 52. No. 5. P. 1153-1159.
- Aseeva E.A., Snigireva G.P., Neverova A.L. et al. Kletki s mnozhestvennymi hromosomnymi narusheniyami v gruppah lic, podvergshihsya oblucheniyu pri razlichnyh situaciyah i ih vozmozhnaya biologicheskaya rol’. Radiac. biologiya. Radioehkologiya. 2009. Vol. 49. No. 5. P. 552-562. (In Russian).
- Byuyul A., Cefel P. SPSS: iskusstvo obrabotki informacii. Saint Petersburg: DiaSoftYuP, 2005, 608 p. (In Russian).
- Andreeva M.M., Volkov V.R. Korrelyacionnyy analiz v sociologicheskih issledovaniyah. Vestnik Kazanskogo tehnologicheskogo universiteta. 2013. Vol. 16. No. 7. P. 271-274.
- Maznik N.A., Vinnikov V.A., Maznik V.S. Ocenka raspredeleniya individual’nyh doz oblucheniya u likvidatorov posledstvij avarii na Chernobyl’skoj AEHS po rezul’tatam citogeneticheskogo analiza. Radiac. biologiya. Radioehkologiya. 2003. Vol. 43. No. 4. P. 412-419. (In Russian).
- Sevan’kaev A.V., Hvostunov I.K., Snigireva G.P. et al. Sravnitel’nyj analiz rezul’tatov citogeneticheskih obsledovanij kontrol’nyh grupp lic v razlichnyh otechestvennyh laboratoriyah. Radiac. biologiya. 2013. Vol. 53. No. 1. P. 5-24. (In Russian).
For citation: Nugis VYu, Bushmanov AYu, Kozlova MG, Tikhonova OA. Cytogenetic Radiation Dose Indication in about 30 Years after the Accident at the Chernobyl NPP. Medical Radiology and Radiation Safety. 2017;62(3):26-32. Russian. DOI: 10.12737/article_5927e7f0092c62.96839938
PDF (RUS) Full-text article (in Russian)