JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2025. Vol. 70. № 1
DOI:10.33266/1024-6177-2025-70-1-21-29
A.V. Gutnov1, O.V. Belov2, G.S. Kachmazov1, T.T. Magkoev1,
N.R. Popova3, N.E. Pukhaeva 1, 2
The Effect of Heavy Ion Irradiation on the Metabolism of Technologically and Biologically Significant Microorganisms: Biotechnological Prospects of Application
1 North Ossetian State University, Vladikavkaz, Russia
2 Joint Institute for Nuclear Research, Dubna, Russia
3 Institute of Theoretical and Experimental Biophysics, Pushchino, Russia
Contact person: A.V. Gutnov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To review the literature on the use of heavy ion beam mutagenesis for selecting various microorganisms, including bacteria, fungi, yeast, and microalgae, for biotechnological purposes.
Material and methods: Data have been collected over the past 15 years on the metabolic effects of mutants exposed to heavy ions, biotechnologically significant microbiological objects (bacteria, fungi, algae).
Results and discussion: The biotechnological and genetic significance, as well as the morphological and other aspects of the detected changes in mutant microbiological objects, are discussed. Currently, heavy ion irradiation-induced mutagenesis with high linear energy transfer and biological efficiency is recognized as a powerful new method for creating microbial strains with previously unknown properties. We believe that targeted breeding using heavy ion mutagenesis will make a significant contribution to the development of industrial producer strains for biotechnology.
Conclusion: The studies discussed in this review indicate that the use of ion beam mutagenesis for microorganisms can be beneficial for both fundamental science and applied research.
Keywords: biotechnology, microorganisms, metabolism, mutagenesis, heavy ion irradiation
For citation: Gutnov AV, Belov OV, Kachmazov GS, Magkoev TT, Popova NR, Pukhaeva NE. The Effect of Heavy Ion Irradiation on the Metabolism of Technologically and Biologically Significant Microorganisms: Biotechnological Prospects of Application. Medical Radiology and Radiation Safety. 2025;70(1):21–29. (In Russian). DOI:10.33266/1024-6177-2025-70-1-21-29
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was performed within the framework of the state assignment of the Ministry of Science and Higher Education of the Russian Federation for the ARIADNA collaboration of the NICA complex (FEFN-2024-0002, FFRS-2024-0019 and FEFN-2024-0006).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2024. Accepted for publication: 25.11.2024.