JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 1
DOI:10.33266/1024-6177-2025-70-1-67-73
A.V. Vertinskiy1, 2, E.A. Selikhova2, E.S. Sukhikh2, 3, V.V. Velikaya3,
O.V. Gribova3, Zh.A. Starceva3
Modernized Software for Calculation and Optimization
of Absorbed Dose Distribution in a Homogeneous Medium during Radiation Therapy with Fast Neutrons
1Tomsk Regional Oncology Center, Tomsk, Russia
2 National Research Tomsk Polytechnic University, Tomsk, Russia
3Tomsk National Research Medical Center, Tomsk, Russia
Contact person: A.V. Vertinskiy, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To modernize software for calculation and optimization of isoeffective and absorbed dose distributions in a homogeneous media when planning fast neutron therapy for malignant tumours.
Material and Methods: The updated absorbed dose calculation system was applied to patients with two localisations, breast cancer (BC) and head and neck cancer (HNC). The study included data from 12 patients, of which 7 were patients with primary locally advanced breast cancer and 5 patients with head and neck cancer. In patients with BC, comprehensive treatment was performed. Patients with malignant tumours of the head and neck region underwent neutron and neutron-photon radiation therapy both in terms of combined treatment and as an independent type of treatment. Breast cancer was irradiated in fractionation mode with 4 fractions of 1.6 Gy each. Field docking was used. Patients diagnosed with head and neck cancer were irradiated in the mode of 3 fractions with a single dose of 2.4 Gy with the duration of the full course of treatment of 8 days. Irradiation took place on the therapeutic channel of the U-120 cyclotron located at Tomsk Polytechnic University.
Results: The planning results showed that the dose to the skin in the irradiation zone was 3.190 Gy and 3.143 Gy for beams 1 and 2, respectively. In the tumour centre, the dose was 3.253 Gy (isoeffective dose 7.980 isoGy). For critical sites (heart), the maximum doses ranged from 0.507 Gy to 1.943 Gy. ). The duration of exposure from each beam was 4 minutes and 26 seconds. For five patients with cancer in the head and neck region, planning was performed using 2 fields separated by an angle of 90 degrees (irradiation angles of 45 and 315 degrees). The fractionation regime included: 3 sessions with tumour dose 2.4 Gy, total dose 7.2 Gy per treatment course. The full course of neutron therapy was carried out in 8 days. TDF in the tumour zone was 55.4 units, with the maximum permissible value of 130 units. As a result, the dose to the skin was from 5.8 to 7.5 Gy. The dose to the tumour centre ranged from 7.1 to 7.23 Gy (taking into account RBE = 2.686 isoeffective dose ranged from 37.9 to 38.4 isoGy). Total treatment time per fraction was from 12.3 to 13.5 minutes.
Keywords: radiation therapy, fast neutron, dosimetric planning, modeling of absorbed dose distribution, U-120 cyclotron, breast cancer, head and neck malignant neoplasms
For citation: Vertinskiy AV, Selikhova EA, Sukhikh ES, Velikaya VV, Gribova OV, Starceva ZhA. Modernized Software for Calculation and Optimization of Absorbed Dose Distribution in a Homogeneous Medium during Radiation Therapy with Fast Neutrons. Medical Radiology and Radiation Safety. 2025;70(1):67–73. (In Russian). DOI:10.33266/1024-6177-2025-70-1-67-73
References
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2024. Accepted for publication: 25.11.2024.