JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-5-10
Yu.B. Deshevoi, V.G. Lebedev, T.A. Nasonova, O.A. Dobrynina,
V.A. Brunchukov, I.V. Kobzeva, T.A. Astrelina, A.S. Samoylov
Study of the Efficacy of Cell Therapy for Severe Local Radiation Injuries in the Use of Drugs Affecting the State of Irradiated Tissues Before Cell Transplantation
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Yu.B. Deshevoi, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the possibility of enhancing the therapeutic efficacy of multipotent mesenchymal stromal cells (MMSC) or stromal vascular fraction (SVF) cells in the treatment of severe local radiation injuries under the conditions of the use of pharmacological drugs, the use of which before and after cell transplantation can improve the condition of the irradiated tissue and thereby create favorable conditions for engraftment and functioning of the injected cells.
Material and methods: The work was carried out on male rats of the Wistar–Kyoto inbred line weighing 260–280 g. The animals were locally irradiated in the iliolumbar region of the back on an X-ray machine LNK-268 (RAP 100–10) at a dose of 110 Gy (voltage on the tube 30 kV, current 6.1 mA, Al filter with a thickness of 0.1 mm), at a dose rate of 20.0 Gy/min. The area of the irradiation field was 8.5 cm2. The severity of radiation damage to the skin and the effects of treatment were assessed in dynamics by clinical manifestations and using planimetry. After exposure to radiation, rats developed radiation ulcers of the skin that did not heal for a long time (up to 3–4 months). Cell and drug therapy were carried out in different periods after irradiation: from the 28th to the 49th or from the 35th to the 56th day. As drugs affecting the condition of the affected tissues surrounding the formed radiation ulcer, a complex antibiotic levotetrasulfin forte and drugs that affect the microcirculation and trophism of irradiated tissues – pentoxifylline and detralex were used. For cell therapy, syngeneous MMSC or SVF cells were used. In the cell therapy setting, the drugs were administered for one week before the first cell transplant, one week between the first and second transplantation, and one week after the second cell transplant.
Results and Conclusion: It was shown that the administration of drugs or the use of cell therapy when used separately stimulated the healing of radiation ulcers. Moreover, the therapeutic effect of cell therapy is more pronounced than with the use of drugs. However, in combination with drug and cell therapy, no enhancing effect of pharmacological agents on the therapeutic efficacy of transplantation of MMSC or SVF cells of adipose tissue was noted. Thus, these experiments showed the possibility of successful use of a complex antibiotic in combination with drugs that improve blood supply and trophism of irradiated tissues in the treatment of severe local radiation injuries and the inability of drug therapy under these conditions to enhance the therapeutic effectiveness of cell therapy.
Keywords: radiation ulcer, transplantation of cells, stromal-vascular fraction of adipose tissue, multipotent mesenchymal stromal cells, drug therapy
For citation: Deshevoi YuB, Lebedev VG, Nasonova TA, Dobrynina OA, Brunchukov VA, Kobzeva IV, Astrelina TA, Samoylov AS. Study of the Efficacy of Cell Therapy for Severe Local Radiation Injuries in the Use of Drugs Affecting the State of Irradiated Tissues Before Cell Transplantation. Medical Radiology and Radiation Safety. 2025;70(3):5–10. (In Russian). DOI:10.33266/1024-6177-2025-70-3-5-10
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.