JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-22-33
L.A. Romodin, A.S. Umnikov, A.S. Samoilov
Biological Reactions under the Combined Action of Ionizing Radiation with Other Factors
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: L.A. Romodin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
This review is devoted to the biological effects of combined exposure to ionizing radiation and factors of a different nature: temperature, non-ionizing radiation, various chemical agents, including heavy metals, immunogenic factors, emotional stress, etc. This effect is often called combined. If we are talking about the combined action of different types of ionizing radiation, for example, neutron and γ-radiation, then such an effect is called combined. The biological effects of the combined action of ionizing radiation and factors of a different nature have been studied by many authors, especially in the field of aerospace and military radiobiology. The review describes cases where the effect of the combined action of ionizing radiation and another factor is approximately equal to the sum of the effects from the action of these factors separately; these effects are called additive. The synergism of effects is described – an increase in the magnitude of the manifestation of effects with a combined action compared to their sum with separate exposure to the studied factors. Works devoted to the conditions for achieving synergistic effects and identifying those under which the degree of synergy will be maximum are analyzed. Cases of a decrease in the magnitude of effects under the combined influence of ionizing radiation and a factor of a different nature are shown in comparison with the effects observed when they act separately ‒ antagonism of effects. Understanding the mechanism of these phenomena is necessary for the successful development of radioprotective agents, the development of countermeasures in case of radiation accidents or the use of nuclear weapons, and the creation of effective means and methods of treating oncological diseases. The review also describes current problems in the use of radioprotectors.
Keywords: ionizing radiation, combined effect, synergism, additivity, antagonism, heavy metals, hyperthermia, non-ionizing radiation, neutrons, γ-radiation
For citation: Romodin LA, Umnikov AS, Samoilov AS. Biological Reactions under the Combined Action of Ionizing Radiation with Other Factors. Medical Radiology and Radiation Safety. 2025;70(3):22–33. (In Russian). DOI:10.33266/1024-6177-2025-70-3-22-33
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.