JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2025. Vol. 70. № 3
DOI:10.33266/1024-6177-2025-70-3-90-98
K.V. Koval, A.S. Tokarev, A.A. Kanibolotskiy, O.L. Evdokimova, A.A. Grin
Pathomorphological Changes in Cell Structures of Cerebral Metastasis of Lung Adenocarcinoma after Neoadjuvant Gamma Knife Radiosurgy. A Case Report
N.V. Sklifosovsky Scientific Research Institute of First Aid, Moscow, Russia
Contact person: K.V. Koval, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To identify and describe morphological changes in the cells of lung adenocarcinoma metastasis to the brain after preoperative (neoadjuvant) Gamma Knife radiosurgery.
Material and methods: A 63-year-old female patient with brain metastases of lung adenocarcinoma including large metastasis in the right frontal lobe. Neoadjuvant stereotactic radiosurgery was performed by Leksell Gamma Knife Icon. Histological and immunohistochemical studies were performed after microsurgical removal of the metastasis in the right frontal lobe. The analysis of scanned images was performed using the NDP.view2 program of the Image Viewing software (© Hamamatsu Photonics K.K.).
Results: The result of histological and immunohistochemical studies is TTF-I+, ROS- lung adenocarcinoma. The most significant changes were coagulation necrosis, vasculopathy, altered blood vessels with endothelial damage, affected cells with pyknotic nuclei, and islets of coagulation necrosis with cells of adenocarcinoma. Despite the descriptive characteristics of early post-radiation changes, apparently caused by radiosurgical exposure, the specific mechanism of post-radiation reactions occurring in malignant cells of cerebral metastases remains to be understood. It is necessary to include the series of cases, in particular, with subsequent analysis of ultramicroscopic findings obtained by electron microscopy.
Keywords: cerebral metastases, neoadjuvant radiosurgery, stereotactic radiosurgery, immunohistochemistry, molecular genetic testing, gamma knife
For citation: Koval KV, Tokarev AS, Kanibolotskiy AA, Evdokimova OL, Grin AA. Pathomorphological Changes in Cell Structures of Cerebral Metastasis of Lung Adenocarcinoma after Neoadjuvant Gamma Knife Radiosurgy. A Case Report. Medical Radiology and Radiation Safety. 2025;70(3):90–98. (In Russian). DOI:10.33266/1024-6177-2025-70-3-90-98
References
1.Вторичное злокачественное новообразование головного мозга и мозговых оболочек: Клинические рекомендации. М., 2020. Электронный ресурс: https://cr.minzdrav.gov.ru/recomend/534_2 (Дата обращения 19.11.2024) [Secondary Malignant Neoplasm of the Brain and Meninges: Clinical Guidelines. Moscow Publ., 2020. URL: https://cr.minzdrav.gov.ru/recomend/534_2 (Accessed 11/19/2024) (In Russ.)].
2.Банов С.М., Голанов А.В., Долгушин М.Б., Бекяшев А.Х., Ветлова Е.Р., Дургарян А.А. Метастатическое поражение головного мозга: современные клинические рекомендации // Онкологический журнал: лучевая диагностика, лучевая терапия. 2018. Т.1. №3. С.75-84 [Banov S.M., Golanov A.V., Dolgushin M.B., Bekyashev A.Kh., Vetlova Ye.R., Durgaryan A.A. Metastatic Brain Damage: Current Clinical Guidelines. Onkologicheskiy Zhurnal: Luchevaya Diagnostika, Luchevaya Terapiya = Oncology Journal: Radiation Diagnostics, Radiation Therapy. 2018;1;3:75-84 (In Russ.)]. doi:10.37174/2587-7593-2018-1-3-75-84.
3.Chao S.T., De Salles A., Hayashi M., Levivier M., Ma L., Martinez R., Paddick I., Régis J., Ryu S., Slotman B.J., Sahgal A. Stereotactic Radiosurgery in the Management of Limited (1-4) Brain Metasteses: Systematic Review and International Stereotactic Radiosurgery Society Practice Guideline. Neurosurgery. 2018;83;3:345-353. doi:10.1093/neuros/nyx522. PMID: 29126142.
4.Grishchuk D., Dimitriadis A., Sahgal A., De Salles A., Fariselli L., Kotecha R., Levivier M., Ma L., Pollock B.E., Regis J., Sheehan J., Suh J., Yomo S., Paddick I. ISRS Technical Guidelines for Stereotactic Radiosurgery: Treatment of Small Brain Metastases (≤1 cm in Diameter). Pract Radiat Oncol. 2023;13;3:183-194. doi:10.1016/j.prro.2022.10.013. PMID: 36435388.
5.Lippitz B., Lindquist C., Paddick I., Peterson D., O’Neill K., Beaney R. Stereotactic Radiosurgery in the Treatment of Brain Metastases. Cancer Treatment Reviews. 2014;40;1:48–59. doi: 10.1016/j.ctrv.2013.05.002. PMID: 23810288.
6.Soffietti R., Abacioglu U., Baumert B., Combs S.E., Kinhult S., Kros J.M., Marosi C., Metellus P., Radbruch A., Villa Freixa S.S., Brada M., Carapella C.M., Preusser M., Le Rhun E., Rudà R., Tonn J.C., Weber D.C., Weller M. Diagnosis and Treatment of Brain Metastases from Solid Tumors: Guidelines from the European Association of Neuro-Oncology (EANO). Neuro Oncol. 2017;19;2:162-174. doi:10.1093/neuonc/now241. PMID: 28391295.
7.Yamamoto M., Serizawa T., Shuto T., Akabane A., Higuchi Y., Kawagishi J., Yamanaka K., Sato Y., Jokura H., Yomo S., Nagano O., Kenai H., Moriki A., Suzuki S., Kida Y., Iwai Y., Hayashi M., Onishi H., Gondo M., Sato M., Akimitsu T., Kubo K., Kikuchi Y., Shibasaki T., Goto T., Takanashi M., Mori Y., Takakura K., Saeki N., Kunieda E., Aoyama H., Momoshima S., Tsuchiya K. Stereotactic Radiosurgery for Patients with Multiple Brain Metastases (JLGK0901): a Multi-Institutional Prospective Observational Study. Lancet Oncol. 2014;15;4:387-395. doi:10.1016/S1470-2045(14)70061-0. PMID: 24621620.
8.Gutschenritter T., Venur V.A., Combs S.E., Vellayappan B., Patel A.P., Foote M., Redmond K.J., Wang T.J.C., Sahgal A., Chao S.T., Suh J.H., Chang E.L., Ellenbogen R.G., Lo S.S. The Judicious Use of Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy in the Management of Large Brain Metastases. Cancers (Basel). 2020;13;1:70. doi:10.3390/cancers13010070. PMID: 33383817.
9.Kondziolka D. Current and Novel Practice of Stereotactic Radiosurgery. J Neurosurg. 2019;130;6:1789-1798. doi:10.3171/2019.2.JNS181712. PMID: 31153140.
10.Redmond K.J., De Salles A.A.F., Fariselli L., Levivier M., Ma L, Paddick I., Pollock B.E., Regis J., Sheehan J., Suh J., Yomo S., Sahgal A. Stereotactic Radiosurgery for Postoperative Metastatic Surgical Cavities: A Critical Review and International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines. Int J Radiat Oncol Biol Phys. 2021;111;1:68-80. doi:10.1016/j.ijrobp.2021.04.016. PMID: 33891979.
11.Leksell Gamma Knife Society. URL: https://www.lgksociety.com/home (Accessed 19.11.2024).
12.Коваль К.В., Токарев А.С., Евдокимова О.Л., Каниболоцкий А.А., Гринь А.А. Особенности патоморфологических изменений в клетках вторичных внутримозговых новообразований после радиохирургии при их комбинированном лечении // Вестник неврологии, психиатрии и нейрохирургии. 2022. №7. С. 497-508 [Koval’ K.V., Tokarev A.S., Yevdokimova O.L., Kanibolotskiy A.A., Grin’ A.A. Features of Pathomorphological Changes in the Cells of Secondary Intracerebral Neoplasms after Radiosurgery during their Combined Treatment. Vestnik Nevrologii, Psikhiatrii i Neyrokhirurgii = Bulletin of Neurology, Psychiatry and Neurosurgery. 2022;7:497-508 (In Rus.)]. doi: 10.33920/med-01-2207-04.
13.Szeifert G.T., Atteberry D.S., Kondziolka D., Levivier M., Lunsford L.D. Cerebral Metastases Pathology after Radiosurgery: a Multicenter Study. Cancer. 2006;106;12:2672-2681. doi:10.1002/cncr.21946. PMID: 16700040.
14.Patel K.R., Burri S.H., Asher A.L., Crocker I.R., Fraser R.W., Zhang C., Chen Z., Kandula S., Zhong J., Press R.H., Olson J.J., Oyesiku N.M., Wait S.D., Curran W.J., Shu H.K., Prabhu R.S. Comparing Preoperative with Postoperative Stereotactic Radiosurgery for Resectable Brain Metastases: A Multi-institutional Analysis. Neurosurgery. 2016;79;2:279-285. doi:10.1227/NEU.0000000000001096. PMID: 26528673.
15.Hirato M., Hirato J., Zama A., Inoue H., Ohye C., Shibazaki T., Andou Y. Radiobiological Effects of Gamma Knife Radiosurgery on Brain Tumors Studied in Autopsy and Surgical Specimens. Stereotact Funct Neurosurg. 1996;66;1:4-16. doi:10.1159/000099695. PMID: 9032840.
16.Kondziolka D., Lunsford L.D., Flickinger J.C. The Radiobiology of Radiosurgery. Neurosurg Clin N Am. 1999;10;2:157-167. PMID: 10099087.
17.Kamada K., Mastuo T., Tani M., Izumo T., Suzuki Y., Okimoto T., Hayashi N., Hyashi K., Shibata S. Effects of Stereotactic Radiosurgery on Metastatic Brain Tumors of Various Histopathologies. Neuropathology. 2001;21;4:307–314. doi:10.1046/j.1440-1789.2001.00404.x. PMID: 11837538.
18.Jain R., Narang J., Sundgren P.M., Hearshen D., Saksena S., Rock J.P., Gutierrez J., Mikkelsen T. Treatment Induced Necrosis Versus Recurrent/Progressing Brain Tumor: Going Beyond the Boundaries of Conventional Morphologic Imaging. J Neurooncol. 2010;100;1:17-29. doi: 10.1007/s11060-010-0139-3. PMID: 20179990.
19.Ветлова Е.Р., Голанов А.В., Банов С.М. Современная стратегия комбинации хирургического и лучевого лечения у пациентов с метастазами в головном мозге // Вопросы нейрохирургии имени Н.Н.Бурденко. 2017. Т.81. №6. С. 108-115 [Vetlova Ye.R., Golanov A.V., Banov S.M. Modern Strategy of Combination of Surgical and Radiation Treatment in Patients with Brain Metastases. Voprosy Neyrokhirurgii imeni N.N.Burdenko = Issues of Neurosurgery named after N.N.Burdenko. 2017;81;6:108-115 (In Russ.)]. doi:10.17116/neiro2017816108-115.
20.Brennan C., Yang T.J., Hilden P., Zhang Z., Chan K., Yamada Y., Chan T.A., Lymberis S.C., Narayana A., Tabar V., Gutin P.H., Ballangrud Å., Lis E., Beal K. A Phase 2 Trial of Stereotactic Radiosurgery Boost after Surgical Resection for Brain Metastases. Int J Radiat Oncol Biol Phys. 2014;88;1:130-136. doi:10.1016/j.ijrobp.2013.09.051. PMID: 24331659.
21.National Comprehensive Cancer Network. Central Nervous System Cancers. URL: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1425 (Accessed 19.11.2024)
22.Prabhu R.S., Patel K.R., Press R.H., Soltys S.G., Brown P.D., Mehta M.P., Asher A.L., Burri S.H. Preoperative vs Postoperative Radiosurgery for Resected Brain Metastases: a Review. Neurosurgery. 2019;84;1:19-29. doi:10.1093/neuros/nyy146. PMID: 29771381.
23.Brown P.D., Ballman K.V., Cerhan J.H., Anderson S.K., Carrero X.W., Whitton A.C., Greenspoon J., Parney I.F., Laack N.N.I., Ashman J.B., Bahary J.P., Hadjipanayis C.G., Urbanic J.J., Barker F.G. 2nd, Farace E., Khuntia D., Giannini C., Buckner J.C., Galanis E., Roberge D. Postoperative Stereotactic Radiosurgery Compared with Whole Brain Radiotherapy for Resected Metastatic Brain Disease (NCCTG N107C/CEC·3): a Multicentre, Randomised, Controlled, Phase 3 Trial. Lancet Oncol. 2017;18;8:1049-1060. doi:10.1016/S1470-2045(17)30441-2. PMID: 28687377.
24.Hatiboglu M.A., Kocyigit A., Guler E.M., Nalli A., Akdur K., Sakarcan A., Ozek E., Uysal O., Mayadagli A. Gamma Knife Radiosurgery Compared to Whole Brain Radiation Therapy Enhances Immunity Via Immunoregulatory Molecules in Patients with Metastatic Brain Tumours. Br J Neurosurg. 2020;34;6:604-610. doi: 10.1080/02688697.2019.1642445. PMID: 31317782.
25.Cleary R.K., Meshman J., Dewan M., Du L., Cmelak A.J., Luo G., Morales-Paliza M., Weaver K., Thompson R., Chambless L.B., Attia A. Postoperative Fractionated Stereotactic Radiosurgery to the Tumor Bed for Surgically Resected Brain Metastases. Cureus. 2017;9;5:e1279. doi: 10.7759/cureus.1279. PMID: 28656127.
26.Patchell R.A., Tibbs P.A., Regine W.F., Dempsey R.J., Mohiuddin M., Kryscio R.J., Markesbery W.R., Foon K.A., Young B. Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain: a Randomized Trial. JAMA. 1998;280;17:1485-1489. doi: 10.1001/jama.280.17.1485. PMID: 9809728.
27.Aoyama H., Tago M., Kato N., Toyoda T., Kenjyo M., Hirota S., Shioura H., Inomata T., Kunieda E., Hayakawa K., Nakagawa K., Kobashi G., Shirato H. Neurocognitive Function of Patients with Brain Metastasis who Received Either Whole Brain Radiotherapy Plus Stereotactic Radiosurgery or Radiosurgery Alone. Int J Radiat Oncol Biol Phys. 2007;68;5:1388-1395. doi: 10.1016/j.ijrobp.2007.03.048. PMID: 17674975.
28.Голанов А.В., Банов С.М., Ильялов С.Р., Ветлова Е.Р., Костюченко В.В. Современные подходы к лучевому лечению метастатического поражения головного мозга // Злокачественные опухоли. 2014. №3. С. 137-140 [Golanov A.V., Banov S.M., Il’yalov S.R., Vetlova Ye.R., Kostyuchenko V.V. Modern Approaches to Radiation Treatment of Metastatic Brain Lesions. Zlokachestvennyye Opukholi = Malignant Tumors. 2014;3:137-140 (In Russ.)]. doi: 10.18027/2224-5057-2014-3-137-140.
29.Голанов А., Банов С., Ильялов С., Трунин Ю.Ю., Маряшев С.А., Ветлова Е.Р., Осинов И.К., Костюченко В.В., Далечина А.В., Дургарян А.А. Радиохирургическое лечение метастазов в головной мозг. Факторы прогноза общей выживаемости и интракраниальных рецидивов // Вопросы нейрохирургии им. Н.Н.Бурденко. 2016. Т.80. №2. C. 35-46 [Golanov A., Banov S., Il’yalov S., Trunin Yu.Yu., Maryashev S.A., Vetlova Ye.R., Osinov I.K., Kostyuchenko V.V., Dalechina A.V., Durgaryan A.A. Radiosurgical Treatment of Brain Metastases. Prognostic Factors of Overall Survival and Intracranial Relapses. Voprosy Neyrokhirurgii im. N.N.Burdenko = Issues of Neurosurgery named after N.N.Burdenko. 2016;80;2:35-46 (In Russ.)]. doi: 10.17116/neiro201680235-46.
30.Elekta Instrument AB. The Convolution Algorithm in Leksell GammaPlan 10. Technical Report. Article No.018881.01. Stockholm, Elekta, 2010.
31.Tokarev A.S., Rak V.A., Evdokimova O.L., Stepanov V.N., Koynash G.V., Viktorova O.A., Kistenev A.V. Standardization of Nomenclature of Targets and Critical Structures in Radiosurgery: The Case of a Single Gamma Knife Center. J Radiosurg SBRT. 2020;7;1:81-84. PMID: 32802582.
32.Ветлова Е.Р., Антипина Н.А., Голанов А.В., Банов С.М. Роль лучевой терапии в лечении метастатического поражения головного мозга // Медицинская физика. 2016. №4. C. 108–118 [Vetlova Ye.R., Antipina N.A., Golanov A.V., Banov S.M. The Role of Radiation Therapy in the Treatment of Metastatic Brain Lesions. Meditsinskaya Fizika = Medical Physics. 2016;4:108–118 (In Russ.)].
33.Szeifert G.T., Salmon I., David P., Devriendt D., De Smedt F., Rorive S., Brotchi J., Levivier M. Tumor Control and Growth in a Patient with Two Cerebral Metastases Treated with the Leksell Gamma Knife. Ed. Kondziolka D. 5th International Stereotactic Radiosurgery Society Meeting, Las Vegas, Nev., June 10–13, 2001. Basel, Karger, 2002. Radiosurgery. Vol. 4. Pp.152–161.
34.Inoue H.K., Kohga H., Hirato M., Nakamura M., Ohye C. Neurobiologic Effects of Radiosurgery: Histologic, Immunohistochemical and Electron-microscopic Studies of a Rat Model. Stereotact Funct Neurosurg. 1994;63;1-4:280-285. doi:10.1159/000100324. PMID: 7624647.
35.Yamada S., Vidal S., Sano T., Horvath E., Kovacs K. Effect of Gamma Knife Radiosurgery on a Pituitary Gonadotroph Adenoma: a Histologic, Immunohistochemical and Electron Microscopic Study. Pituitary. 2003;6;1:53-8. doi: 10.1023/a:1026238028623. PMID: 14674725.
36.Kihlström L., Karlsson B. Imaging Changes after Radiosurgery for Vascular Malformations, Functional Targets and Tumors. Neurosurg Clin N Am. 1999;10;2:167–180. PMID: 10099102.
37.Wolf D., Germano I.M. Radionecrosis: Clinical and Histological Aspects. Ed. Germano I. LINAC and Gamma Knife Radiosurgery. Park Ridge, AANS, 2000. Pp.75–82.
38.Julow J., Slowik F., Kelemen J., Gorácz I. Late Post-Irradiation Necrosis of the Brain. Acta Neurochir (Wien). 1979;46;1-2:135–150. doi: 10.1007/BF01407687. PMID: 452964.
39.Szeifert G. Radiosurgery and AVM Histopathology. J Neurosurg. 1998;88;2:356–357. doi: 10.3171/jns.1998.88.2.0356. PMID: 9452254.
40.Szeifert G., Major O., Fazekas I., Nagy Z. Effects of Radiation on Cerebral Vasculature: a Review. Neurosurgery. 2001;48;2:452–453. doi: 10.1097/00006123-200102000-00051. PMID: 11220396.
41.Major O., Szeifert G.T., Radatz M.W., Walton L., Kemeny A.A. Experimental Stereotactic Gamma Knife Radiosurgery. Vascular Contractility Studies of the Rat Middle Cerebral Artery after Chronic Survival. Neurol Res. 2002;24;2:191–198. doi: 10.1179/016164102101199602. PMID: 11877904.
42.Szeifert G.T., Kemeny A.A., Timperley W.R., Forster D.M. The Potential Role of Myofibroblasts in the Obliteration of Arteriovenous Malformations after Radiosurgery. Neurosurgery. 1997;40;1:61-65; Discussion 65-66. doi: 10.1097/00006123-199701000-00013. PMID: 8971825.
43.Schneider B.F., Eberhard D.A., Steiner L.E. Histopathology of Arteriovenous Malformations after Gamma Knife Radiosurgery. J Neurosurg. 1997;87;3:352–357. doi: 10.3171/jns.1997.87.3.0352. PMID: 9285598.
44.Yamamoto M., Hara M., Ide M., Ono Y., Jimbo M., Saito I. Radiation-Related Adverse Effects Observed on Neuro-Imaging Several Years after Radiosurgery for Cerebral Arteriovenous Malformations. Surg Neurol. 1998;49;4:385–398. doi: 10.1016/s0090-3019(97)00531-4. PMID: 9537656.
45.Major O., Kemeny A.A., Forster D.M., Jakubowski J., Morice A.H. In vitro Contractility Studies of the Rat Middle Cerebral Artery after Stereotactic Gamma Knife Radiosurgery. Stereotact Funct Neurosurg. 1996;66;1:17–28. doi: 10.1159/000099697. PMID: 9032841.
46.Szeifert G.T., Salmon I., Balèriaux D., Brotchi J., Levivier M. Immunohistochemical Analysis of a Cerebral Arteriovenous Malformation Obliterated by Radiosurgery and Presenting with re-Bleeding. Case Report. Neurol Res. 2003;25;7:718–721. doi: 10.1179/016164103101202228. PMID: 14579789.
47.Lippitz B.E., Harris R.A. A Translational Concept of Immuno-Radiobiology. Radiother Oncol. 2019;140:116-124. doi: 10.1016/j.radonc.2019.06.001. PMID: 31271996.
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.02.2025. Accepted for publication: 25.03.2025.