JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 4
DOI:10.33266/1024-6177-2025-70-4-21-24
V.Yu. Soloviev, A.Yu. Bushmanov, I.B. Ushakov, O.V. Nikitenko, T.M. Bychkova,
A.A. Ivanov , Yu.A. Fedotov, M.L. Ganzhelyuk, L.Yu. Mershin, A.S. Kretov,
T.I. Gimadova, Dmitrij M. Alekseev, Daniil M. Alekseev, A.N. Osipov
Experimental Study of Radioprotective Efficiency of Indralin
in Outbred Mice icr (cd-1) spf-Category Irradiation
with Pulsed Bremsstrahlung X-Rays in Ultra-High Dose Rate (flash) Mode
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.Yu. Soloviev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Objective: To study the radioprotective efficacy of indralin when mice were irradiated with pulsed X-ray bremsstrahlung in the ultra-high dose rate (FLASH) mode.
Material and methods: Outbred ICR (CD-1) mice of the SPF category were used as the object of the study. All study groups were randomized by body weight at the preparatory stage. During the studies, a setup based on the ILU-14 pulsed linear resonance electron accelerator with a converter was used as a source of X-ray bremsstrahlung. The radiation dose was controlled by thermoluminescent dosimeters in the individual dosimetry mode. The 30-day survival of laboratory animals under conditions without the use of drugs and with the use of indralin, administered 15 minutes before irradiation, was considered as the effect under study. When assessing the dose–effect characteristic, two options were considered: peak dose rate of bremsstrahlung X-rays 12.5 Gy/s (normal mode) and 109–147 Gy/s (FLASH mode). The results of the dose–effect dependence with 80–90 % mortality of mice within 30 days were comparable. The effectiveness of the drug indralin was assessed in the FLASH mode (peak dose rate 147–153 Gy/s, average – 2.2–2.3 Gy/s). Irradiation of the control and study groups of animals was carried out simultaneously.
Results: The study revealed high protective efficacy of indralin when outbred ICR (CD-1) SPF mice were irradiated with pulsed X-ray bremsstrahlung in the ultra-high dose rate mode (FLASH) at a dose of 8.9 Gy, the 30-day survival rate in the control was 40 %, and when using indralin – 100 %; at a dose of 9.1 Gy, there were no surviving animals in the control, and when using indralin, the survival rate was 70 %.
Conclusion: Significant protective efficacy of indralin was demonstrated when mice were irradiated with pulsed bremsstrahlung X-rays in the FLASH mode.
Keywords: bremsstrahlung X-rays, ultra-high dose rate (FLASH), mice, 30-day survival, indralin
For citation: Soloviev VYu, Bushmanov AYu, Ushakov IB, Nikitenko OV, Bychkova TM, Ivanov AA, Fedotov YuA, Ganzhelyuk ML, Mershin LYu, Kretov AS, Gimadova TI, Alekseev Dmitrij M, Alekseev Daniil M, Osipov AN. Experimental Study of Radioprotective Efficiency of Indralin in Outbred Mice icr (cd-1) spf-Category Irradiation with Pulsed Bremsstrahlung X-Rays in Ultra-High Dose Rate (flash) Mode. Medical Radiology and Radiation Safety. 2025;70(4):21–24. (In Russian). DOI:10.33266/1024-6177-2025-70-4-21-24
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.03.2025. Accepted for publication: 25.04.2025.