JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5
DOI:10.33266/1024-6177-2025-70-5-18-22
A.Yu. Bushmanov, V.Yu. Soloviev, V.V. Zorin, O.V. Nikitenko, T.M. Bychkova,
A.O. Lebedev, A.A. Ivanov , Yu.A. Zrilova, T.A. Astrelina, V.A. Brunchukov,
L.M. Rozhdestvenskyj, Yu.A. Fedotov, T.I. Gimadova, L.Yu. Mershin, A.S. Kretov,
T.G. Shlyakova, A.N. Osipov
Evaluation of the Effectiveness of the Drug Indralin in the Irradiation of Small, Medium and Large Laboratory Animals with Gamma Radiation
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: V.Yu. Soloviev, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Evaluation of the effectiveness of the drug indralin in experiments with small, medium and large laboratory animals.
Material and methods: The objects of the study were outbred male mice of the ICR (CD-1) SPF category, rabbits of the “Soviet Chinchilla” breed, mini-pigs of the Svetlogorsk breed and beagle dogs. The experimental animals were kept in conventional conditions, on standard granulated feed and tap drinking water. During the studies, the radionuclide installation GUT200M (60Co) and the installation for generating bremsstrahlung X-rays based on the pulsed linear resonance electron accelerator ILU-14 were used as radiation sources. Mice, mini-pigs and dogs were irradiated using the GUT200M (60Co) installation, rabbits – using the ILU-14 installation. The radiation dose was controlled by thermoluminescent dosimeters in the individual dosimetry support mode. The biological effect was assessed in terms of 30-day survival for mice and rabbits and 45-day survival for large laboratory animals (mini-pigs and dogs). At the first stage, the dose-effect relationship was assessed for all experimental animals, and the irradiation conditions that ensured 80-90% mortality of animals were assessed. At the second stage, the effectiveness of indralin was assessed.
Results: The following estimates were obtained: LD50/30: mice – 7.9±0.2, rabbits – 9.6±0.3; LD50/45: mini-pigs – 2.7±0.2 Gy, dogs – 2.4±0.3 Gy; LD84/30: mice – 8.7±0.4 Gy, rabbits – 10.0±0.2 Gy; LD84/45: mini-pigs – 3.1±0.2 Gy, dogs – 3.2±0.2 Gy. In the experiment on mice: when irradiated at doses of 8.7 and 10.3 Gy, there were no surviving mice in the control, while when using indralin, the proportion of surviving animals was 68 % and 38 %, respectively. In the experiment on mini-pigs: in the control 9 % survived, with indralin – 75 %; for dogs: in the control 14 % survived, with indralin – 86 %. In the experiment on rabbits, the positive effect was insignificant: there were no survivors in the control, while when using indralin at a dose of 21 mg/kg, the proportion of survivors was 15 %, and at a dose of 37.5 mg/kg – 25 %.
Conclusion: In an experiment on small, medium and large laboratory animals, the high efficiency of the drug indralin was confirmed when used in regulated doses 10–15 minutes before irradiation.
Keywords: X-rays, laboratory animals, survival, radioprotective drugs, indralin
For citation: Bushmanov AYu, Soloviev VYu, Zorin VV, Nikitenko OV, Bychkova TM, Lebedev AO, Ivanov AA, Zrilova YuA, Astrelina TA, Brunchukov VA, Rozhdestvenskyj LM, Fedotov YuA, Gimadova TI, Mershin LYu, Kretov AS, Shlyakova TG, Osipov AN. Evaluation of the Effectiveness of the Drug Indralin in the Irradiation of Small, Medium and Large Laboratory Animals with Gamma Radiation. Medical Radiology and Radiation Safety. 2025;70(5):18–22. (In Russian). DOI:10.33266/1024-6177-2025-70-5-18-22
References
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3. Vasin M.V., Il’in L.A., Ushakov I.B. Phenomenon of Radiation Protection by Indralin in Large Animals (Dogs) and its Extrapolation to Humans. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2022;67;3:5-12 (In Russ.). doi:10.33266/1024-6177-2022-67-3-5-12
4. Vasin M.V., Kovtun V.Yu., Ushakov I.B., Afanas’yev R.V., Mirzoyan R.S., Ganshina T.S., Semenova L.A., Koroleva L.V., Galkin A.A. Sposob Snizheniya Nezhelatel’nykh Pobochnykh Effektov Preparata B-190 = Method for Reducing Unwanted Side Effects of the drug B-190. Patent RU2575576C2. Published 20.02.2016. Bulletin No. 5 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2025. Accepted for publication: 25.06.2025.