JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5
DOI:10.33266/1024-6177-2025-70-5-63-69
T.V. Azizova1, E.S. Grigoryeva1, N. Hamada2
Influence of Dose Rate on Mortality from Coronary Heart Disease in the Mayak Employee Cohort
1 Southern Urals Federal Medical Biophysics Research Centre, Ozyorsk, Russia
2 Central Research Institute of Electric Power Industry (CRIEPI), Tokyo, Japan
Contact person: T.V. Azizova , e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: The study aimed to evaluate the impact of radiation dose rate on the mortality from ischemic heart disease (IHD) in a cohort of workers chronically exposed to ionizing radiation.
Material and methods: The study considered the subcohort of the Mayak Production Association (PA) workers (WSC) who were hired between 1948 and 1982 and were living in the city of Ozyorsk (residents). The WSC included 13,156 individuals who were followed up until December 31, 2018 (13,156 individuals). To assess the impact of dose rate on the mortality from IHD, the dose window method was applied. In the first phase of the study, we analyzed the dose-response relationship using the excess relative risk (ERR) per unit dose of external radiation exposure (in Gy) based on the conventional linear model. Subsequently, we performed the analysis considering the radiation dose rate by utilizing annual doses recorded with individual film badge dosimeters. We defined the dose rate cut-off points from 5 to 50 mGy/year, with intervals of 5 mGy. To compare the conventional model with the dose-rate models, the maximum likelihood technique was used. All the calculations were carried out using the AMFIT module of the EPICURE software.
Results: We found the significantly increased IHD mortality risk in workers exposed at dose rates >0.015 Gy/year, >0.020 Gy/year, >0.025 Gy/year, >0.030 Gy/year, >0.035 Gy/year, >0.040 Gy/year, >0.045 Gy/year, >0.050 Gy/year compared to dose rates below these cut-off points. The uninterrupted radiation exposure at dose rate above a cut-off point during 5 consecutive years considerably increased the IHD mortality risk. Exclusion of the adjustment for alpha dose from the model resulted in the decrease of the ERR/Gy at higher dose rate and to the loss of the statistical significance for certain cut-off points (0.045 and 0.050 Gy). On the contrary, the exclusion of this adjustment resulted in the increase in risk estimates at lower dose rates for all cut-off points without any changes in the statistical significance of the estimates.
Conclusions: The study results indicate that the excess relative risks of the IHD mortality per unit dose of external radiation exposure in nuclear workers chronically exposed to ionizing radiation depended on the dose rate and the duration of the uninterrupted exposure at higher dose rates.
Keywords: mortality, ischemic heart disease, ocupational radiation exposure, ionizing radiation dose rate
For citation: Azizova TV, Grigoryeva ES, Hamada N. Influence of Dose Rate on Mortality from Coronary Heart Disease in the Mayak Employee Cohort. Medical Radiology and Radiation Safety. 2025;70(5):63–69. (In Russian). DOI:10.33266/1024-6177-2025-70-5-63-69
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2025. Accepted for publication: 25.06.2025.