JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 5
DOI:10.33266/1024-6177-2025-70-5-70-74
A.M. Korelo, M.A. Maksioutov, S.Yu. Chekin, K.A. Tumanov,
N.V. Shchukina, E.V. Kochergina, O.E. Lashkova, N.S. Zelenskaya, V.K. Ivanov
Influence of Exposure Duration on Radiation-Induced Morbidity Among Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant
А.F. Tsyb Medical Radiological Research Centre, Obninsk, Kaluga region, Russia
Contact person: A.M. Korelo, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To assess the effect of exposure duration on radiation-induced morbidity.
Material and methods: Retrospective cohort study of the influence of the duration of exposure on radiation-induced morbidity of the participants of the liquidation of the Chernobyl accident consequences according to the data of the National Radiation Epidemiologic Register. The SOLID cohort consisted of 67616 persons who had no diagnoses of “solid malignant neoplasms other than skin cancer” before January 1, 1992. The HEART cohort consisted of 69456 persons who had no cardiovascular diseases before January 1, 1988: ischemic heart disease, heart failure, conduction and heart rhythm disorders, heart valve disease and lesions. The end of follow-up is 2023. Observed cohort morbi-
dity was modeled by assuming that the number of disease cases had a Poisson distribution. Three models were tested: non-radiation risk, li-
near relative radiation risk, and exposure time-adjusted linear relative radiation risk. Non-radiation incidence was modeled as an exponential dependence on the region of residence, age at the time of exposure, and calendar year of observation. Adjustment for the time of radiation exposure was modeled as an exponential function. Estimates of coefficients of morbidity models were obtained by the maximum likelihood method using the programming language for statistical calculations R and the packages for R gnm and data.table.
Results: The linear relative radiation risk model was preferred over the non-radiation risk model for both the SOLID cohort (p<0.001) and the HEART cohort (p<0.001). The excess relative radiation risk per 1 Gy was 0,67 (95 % confident interval (CI): 0.37; 1.00) for the SOLID cohort and 0,66 (95 % CI: 0.51; 0.81) for the HEART cohort. Adjustment for exposure time was not statistically significant for the SOLID cohort (–0.10; 95 % ДИ: –0.46; 0.26; p=0.38) but statistically significantly less than 0 for the HEART cohort (–1.19; 95 % ДИ: –1.63; –0.76; p<0.001) – the longer the duration of exposure, the smaller the excess relative radiation risk per 1 Gy.
Conclusion: In the studied cohort of Russian participants of the Chernobyl accident consequences liquidation, a sixfold decrease of the relative radiation risk coefficient per unit dose with increasing duration of exposure from 1 to 100 days was revealed for the incidence of cardiovascular diseases (ischemic heart disease, heart failure, conduction and heart rhythm disorders, heart valve diseases and lesions). For the incidence of solid malignant neoplasms (excluding non-melanoma skin cancer) no statistically significant dependence of the relative radiation risk coefficient on the duration of exposure was revealed. The obtained results indicate significant differences in radiation-epidemiologic peculiarities of malignant neoplasms and tissue reactions (heart diseases).
Keywords: Chernobyl accident liquidators, National Radiation Epidemiological Register, morbidity, dose, dose rate, external gamma radiation, exposure duration, cohort study, radiation risk
For citation: Korelo AM, Maksioutov MA, Chekin SYu, Tumanov KA, Shchukina NV, Kochergina EV, Lashkova OE, Zelenskaya NS, Ivanov VK. Influence of Exposure Duration on Radiation-Induced Morbidity Among Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant. Medical Radiology and Radiation Safety. 2025;70(5):70–74. (In Russian). DOI:10.33266/1024-6177-2025-70-5-70-74
References
1. ICRP, 2007. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann. ICRP. 2007;37;2–4:1–332.
2. ICRP, 1991. The 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann. ICRP. 1991;21;1–3:1–201.
3. ICRP, 2025. Task Group 91. Radiation Risk Inference at Low-Dose and Low-Dose Rate Exposure for Radiological Protection Purposes. URL: http://www.icrp.org/icrp_group.asp?id=83 (Date of Access: 05.05.2025).
4. Lowe D., Roy L., Tabocchini M.A., Rühm W., Wakeford R., Woloschak G.E., Laurier D. Radiation Dose Rate Effects: what is New and What is Needed? Radiat. Environ. Biophys. 2022;61;4:507–543. doi: 10.1007/s00411-022-00996-0.
5. Azizova T.V., Grigoryeva E.S., Hamada N. Dose Rate Effect on Mortality from Ischemic Heart Disease in the Cohort of Russian Mayak Production Association Workers. Sci. Rep. 2023;13;1:1926. doi: 10.1038/s41598-023-28954-w.
6. Furuta H., Kudo S., Ishida J., Yoshimoto K., Kasagi F. Dose-Rate Effects on Cancer Mortality Risk Estimates for Japanese Nuclear Workers. Proceedings of the 2nd European Radiological Protection Research Week. Paris, 2017. URL: https://www.rea.or.jp/ire/pdf/20171010Furuta.pdf (Date of Access: 05.05.2025).
7. Sasaki M., Kudo S., Furuta H. Effect of Radiation Dose Rate on Cancer Mortality among Nuclear Workers: Reanalysis of Hanford Data. Health Phys. 2019;117;1:13–19. doi: 10.1097/HP.0000000000001039.
8. Sasaki M., Kudo S., Furuta H. Effect of Radiation Dose Rate on Circulatory Disease Mortality among Nuclear Workers: Reanalysis of Hanford Data. Health Phys. 2020;119;3:280–288. doi: 10.1097/HP.0000000000001230.
9. Иванов В.К., Максютов М.А., Туманов К.А., Кочергина Е.В., Власов О.К., Чекин С.Ю., Горский А.И., Корело А.М., Щукина Н.В., Зеленская Н.С., Лашкова О.Е., Иванов С.А., Каприн А.Д. 35-летний опыт функционирования НРЭР как государственной информационной системы мониторинга радиологических последствий Чернобыльской катастрофы // Радиация и риск. 2021. Т. 30. №1. С. 7–39 [Ivanov V.K., Maksyutov M.A., Tumanov K.A., Kochergina Ye.V., Vlasov O.K., Chekin S.Yu., Gorskiy A.I., Korelo A.M., Shchukina N.V., Zelenskaya N.S., Lashkova O.Ye., Ivanov S.A., Kaprin A.D. 35-Year Experience in the Functioning of the National Radiation and Epidemiological Registry as a State Information System for Monitoring the Radiological Consequences of the Chernobyl Accident. Radiatsiya i Risk = Radiation & Risk. 2021;30;1:7-39 (In Russ.)]. doi: 10.21870/0131-3878-2021-30-1-7-39.
10. Международная статистическая классификация болезней и проблем, связанных со здоровьем, 10-й пересмотр (МКБ-10). Т. 1 (часть 1). Женева, ВОЗ, 1995. 698 с. [Mezhdunarodnaya Statisticheskaya Klassifikatsiya Bolezney i Problem, Svyazannykh so Zdorov’yem, 10-y Peresmotr (MKB-10) = International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). Vol. 1 (Part 1). Geneva, WHO Publ., 1995. 698 p. (In Russ.)].
11. Кащеев В.В., Чекин С.Ю., Карпенко С.В., Максютов М.А., Туманов К.А., Кочергина Е.В., Глебова С.Е., Иванов С.А., Каприн А.Д. Оценка радиационных рисков злокачественных новообразований среди российских участников ликвидации последствий аварии на Чернобыльской АЭС // Радиация и риск. 2021. Т. 30. № 1. С. 58–77 [Kashcheyev V.V., Chekin S.Yu., Karpenko S.V., Maksyutov M.A., Tumanov K.A., Kochergina Ye.V., Glebova S.Ye., Ivanov S.A., Kaprin A.D. Assessment of Radiation Risks of Malignant Neoplasms among Russian Participants in the Liquidation of the Consequences of the Chernobyl Accident. Radiatsiya i Risk = Radiation & Risk. 2021;30;1:58-77 (In Russ.)].
12. Чекин С.Ю., Максютов М.А., Кащеев В.В., Карпенко С.В., Туманов К.А., Кочергина Е.В., Зеленская Н.С., Лашкова О.Е. Оценка радиационных рисков неонкологических заболеваний среди российских участников ликвидации последствий аварии на Чернобыльской АЭС // Радиация и риск. 2021. Т. 30. № 1. С. 78–93 [Chekin S.Yu., Maksyutov M.A., Kashcheyev V.V., Karpenko S.V., Tumanov K.A., Kochergina Ye.V., Zelenskaya N.S., Lashkova O.Ye. Assessment of Radiation Risks of Non-Oncological Diseases among Russian Participants in the Liquidation of the Consequences of the Chernobyl Accident. Radiatsiya i Risk = Radiation & Risk. 2021;30;1:78-79 (In Russ.)].
13. R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing. Vienna, Austria. URL: https://www.R-project.org/ (Date of Access: 05.05.2025).
14. Turner H., Firth D. Generalized Nonlinear Models in R: an Overview of the GNM Package (R Package Version 1.1-5). URL: https://CRAN.R-project.org/package=gnm) (Date of Access: 05.05.2025).
15. Barrett T., Dowle M., Srinivasan A., Gorecki J., Chirico M., Hocking T., Schwendinger B., Krylov I. 2025 Data. Table: Extension of ‘Data.Frame’ (R Package Version 1.17.99). URL: https://r-datatable.com) (Date of Access: 05.05.2025).
16. Sokolnikov M., Preston D., Gilbert E., Schonfeld S., Koshurnikova N. Radiation Effects on Mortality from Solid Cancers other than Lung, Liver, and Bone Cancer in the Mayak Worker Cohort: 1948–2008. PLoS One. 2015;10;2:e0117784. doi: 10.1371/journal.pone.0117784.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.05.2025. Accepted for publication: 25.06.2025.