SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 5. P. 52-63

REVIEW

DOI: 10.12737/article_59f30321207ef4.88932385

Locoregional Hyperthermia of Malignant Tumors: Methods, Thermometry, Machines

O.K. Kurpeshev1, J. van der Zee2

1. A.F. Tsyb Medical Radiological Research Center, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Erasmus Medical Centre, Cancer Institute, Rotterdam, the Netherlands

O.K. Kurpeshev – Dr. Sc. Med., Head of Local and Whole Body Hyperthermia Department, Member of European Society for Hyperthermic Oncology (ESHO); J. van der Zee – Ph.D., MD, Member of European Society for Therapeutic Radiology and Oncology (ESTRO), European Society for Hyperthermic Oncology (ESHO)

Abstract

The review presents an analytical review of the basic techniques of radiofrequency HT, thermometry, characteristics of some hyperthermic apparatus for locoregional HT (LRHT). All methods of LRHT aim to create a relatively uniform temperature distribution in the tumor in the range of 41–46 °Ϡwithout overheating the normal tissues. However, this is not always achievable, and especially difficult for deep-seated tumors. This is due to certain limitations or disadvantages of the available hyperthermic systems. Application of LRHT is a complex procedure and therefore hyperthermia treatment remains a privilege for the major cancer clinics. There are only general guidelines for the application of LRHT, standards of treatment are difficult to define due to the inhomogeneous distribution of the electromagnetic (EM) power in organs and tissues (tumors) at different frequencies. Standards of treatment should be developed for each specific device on the basis of experimental and clinical studies. A common problem for all hyperthermia systems is the limited possibility to temperature monitoring. A possible solution to this problem is to use magnetic resonance imaging (MRI) or ultrasound (US) for non-invasive thermometry. The application of LRHT to deep-seated tumors is mainly done with capacitive systems, or radiative systems with phased array antennas. The limiting factor in capacitive HT is overheating of the subcutaneous fat (SF). The application of LRHT to superficial tumors is best done with radiative applicators, because this method has the optimal temperature distribution. The heating pattern of radiative systems in depth depends of the frequency of the used electromagnetic radiation. The superficial temperature can be influenced by a perfused water bolus.

Key words: hyperthermia, electromagnetic fields, radio frequency radiation, ultrasonic radiation, laser radiation, thermometry, hyperthermic devices

References

  1. Kurpeshev O.K., Pavlov V.V., Shklyayev S.S. Effektivnost’ lokal’noy gipertermii pri khimioterapevticheskom i/ili luchevom lechenii limfomy Khodzhkina. Sibirskiy onkologicheskiy zh. 2013. Vol. 58. No. 4. P. 28–30. (In Russ.).
  2. Kurpeshev O.K., Andreyev V.G., Pankratov V.A. et al. Sravnitel’nyye rezul’taty konservativnoy khimioluchevoy i termokhimioluchevoy terapii mestnorasprostranennogo raka gortani. Voprosy onkologii. 2014. Vol. 60. No. 5. P. 602–606. (In Russ.).
  3. Maluta S. J., Omano M., Dall’oglio S. et al. Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum. Int. J. of Hyperthermia. 2010. Vol. 26. No. 2. P. 108–117.
  4. Van der Zee J., De Bruijne M., Mens J.W.M. et al. Reirradiation combined with hyperthermia in breast cancer recurrences: Overview of experience in Erasmus MC. Int. J. Hyperthermia. 2010. Vol. 26. No. 7. P. 638–648.
  5. Canters R.A.M., Paulides M.M., Franckena M.F. et al. Implementation of treatment planning in the routine clinical procedure of regional hyperthermia treatment of cervical cancer: An overview and the Rotterdam experience. Int. J. Hyperthermia. 2012. Vol. 28. No. 6. P. 570–581. DOI:10.3109/02656736.2012.675630.
  6. Pang C.L.K. Hyperthermia in Oncology. Guangzhou University of Chinese medicine. CRC Press. Tylor & Francis Group. 2016. 353 p.
  7. Short Dzh. G., Terner P.F. Primeneniye fizicheskoy gipertermii dlya lecheniya zlokachestvennykh novoobrazovaniy. TIIER. 1980. Vol. 68. P. 157–169.
  8. El-Kareh A.W., Secomb T.W. A theoretical model for intraperitoneal delivery of cisplatin and the effect of hyperthermia on drug penetration distance. Neoplasia. 2004. No. 6. P. 117–127.
  9. González-Moreno S., González-Bayón L. A., Ortega-Pérez G. Hyperthermic intraperitoneal chemotherapy: Rationale and technique. World J. Gastroint. Oncol. 2010. Vol. 2. No. 2. P. 68–75.
  10. Mi D.H., Li Z., Yang K.H. et al. Surgery combined with intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) for gastric cancer: A systematic review and meta-analysis of randomised controlled trials. Int. J. Hyperthermia. 2013. Vol. 29. No. 2. P. 156–167.
  11. Stehlin J.S., Giovanella B.C., Gutierrez A.E. et al. 15 year’s experience with hyperthermic perfusion for treatment of soft tissue sarcoma and malignant melanoma of the extremities. Hypert. Radat. Ther. : Chemother. Treat. Cancer. 18th Annual Cancer Symposium. Basel: 1984. P. 177–182.
  12. Klicks R.J., Vrouenraets B.C., Nieweg O.E., Kroon B.B.R. Vascular complications of isolated limb perfusion. Eur. J. Surg. Oncol. 1998. Vol. 24. P. 281–291.
  13. Klauser J.M., Lev-Chelouche D., Meller I. et al. Isolated limb perfusion in the treatment of advanced soft-tissue sarcomas. In: Musculoskeletal Cancer Surgery: Treatment of Sarcomas and Allied Diseases. Ed. Malawar M.M., Sugarbaker P.H. New-York, Boston, Dordrecht, London, Moscow. Kluwer Academic Publishers. 2004. P. 75–84.
  14. Gel’vich E.A., Mazokhin V.N. Tekhnicheskiye aspekty elektromagnitnoy gipertermii v meditsine. Meditsina i biotekhnologiya. 1998. No. 1. P. 37–47. (In Russ.).
  15. Shtemler V.M., Kolesnikov S.V. Osobennosti vzaimodeystviya elektromagnitnykh poley s bioob”yektami. Fiziologiya cheloveka i zhivotnykh. Vol. 22. Moscow: Meditsina. 1978. P. 9–67. (In Russs.).
  16. Corry P.M., Barlogie B., Tilchen E.J., Armour E.P. Ultrasound induced hyperthermia for of human superficial tumors. Int. J. Radiat. Oncol., Biol. Phys. 1982. Vol. 8. No. 9. P. 1225–1229.
  17. Rossmann C., Haemmerich D. Review of temperature dependence of thermal properties, dielectric properties, and perfusion of biological tissues at hyperthermic and ablation temperatures. Crit Rev. Biomed. Eng. 2014. Vol. 42. No. 6. P. 467–492.
  18. Kok H. P., Crezee J. A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia. Int. J. Hyperthermia. 2017. Vol. 33. No. 4. P. 378–386. DOI: 10.1080/02656736.2016.1268726.
  19. Trefná H. D., Crezee H., Schmidt M. et al. Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. Int. J. of Hyperthermia. 2017. Vol. 33. No. 4. P. 471–482. DOI: 10.1080/02656736.2016.1277791.
  20. Brezovich I. A. Heating of subcutaneous fat in localized current field hyperthermia with external electrodes. Med. Phys. 1979. Vol. 6. No. 4. P. 352.
  21. Moon C.W., Yum H.Y. Results of hyperthermia in combination of radiation and/or chemotherapy for locally advanced gastric cancer. Proc. Int. Congress on Hyperthermic Oncol., 7th. Roma: 1996. Vol. 2. P. 40–42.
  22. Tanaka Y., Kawamori J., Shimada T. et al. Clinical experience with RF-capacitive heating in the treatment of deep sated tumors: analysis on relationship of the treatment parameters and local responses. Abstr. Int. Congress on Hyperthermic Oncol., 7th. Vol. 2. Roma: 1996. P. 44–46.
  23. Saxena I.F., Hui K. Polymer coated fiber Bragg grating thermometry for microwave Hyperthermia. Med. Phys. 2010. Vol. 37. No. 9. P. 4615–4619.
  24. Kuroda K., Morita S., Lam M. K. et al. Feasibility of noninvasive magnetic resonance temperature imaging of fat and water based on methylene proton spin-lattice relaxation time and water proton resonance frequency. Thermal Med. 2012. Vol. 28. No. 4. P. 87–96.
  25. van Dongen K. W. A., Verweij M.D. A feasibility study for non-invasive thermometry using non-linear ultrasound. Int. J. Hyperthermia. 2011. Vol. 27. No. 6. P. 612–624.
  26. Sapareto S.A., Dewey W.C. Thermal dose determination in cancer therapy. Int.J. Radiat. Oncol. Biol. Phys. 1984. Vol. 10. P. 787–800.
  27. De Bruijne M., van der Holt B., van Rhoon G. C., van der Zee J. Evaluation of CEM 43 °C T90 thermal dose in superficial hyperthermia. Strahlentherapie und Onkologie. 2010. Vol. 186. No. 8. P. 436–443.
  28. Kurpeshev O.K., Pasov A.K., Kurpesheva A.K. Lokal’naya gipertermiya pri lechenii pozdnikh luchevykh povrezhdeniy. Metodicheskiye rekomendatsii. FS 2016/266 ot 12.09.2011. Obninsk. 2012. 17 p. (In Russ.).
  29. Kurpeshev O.K., Tsyb A.F., Mardynskiy YU.S. et al. Lokal’naya gipertermiya v luchevoy terapii zlokachestvennykh opukholey (eksperimental’no-klinicheskoye issledovaniye). Obninsk. 2007. 219 p. (In Russ.).
  30. Van Rhoon G.C., Van Der Heuvel D.J., Ameziane P. et al. Characterization of the SAR-distribution of the Sigma-60 applicator for regional hyperthermia using a Schottky diode sheet. Int. J. of Hyperthermia. 2003. Vol. 19. No. 6. P. 642–654. DOI:10.1080/0265673031000140813.
  31. Fatehi D., Van Der Zee J., Wielheesen D. H. M. et al. Intra-luminal thermometry: Is tissue type assignment a necessity for thermal analysis. Int. J. Hyperthermia. 2006. Vol. 22. No. 6. P. 463–473.
  32. Balzer S., Schneider D.T., Bernbeck M.B. et al. Avascular osteonecrosis after hyperthermia in children and adolescents with pelvic malignances: A retrospective analysis of potential risk factors. Int. J. of Hyperthermia. 2006. Vol. 22. No. 6. P. 451–461.
  33. Van der Zee J., Gonzales D., van Rhoon G.O. et al. Comparison of radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomised, multicentre trial. Lancet. 2000. Vol. 355. P. 1119–1125.
  34. Wust P., Wlodarczyk W., Ganter H. et al. MR monitoring for deep heating of pelvic tumors present status and outlook.. 22nd An. Meeting of the Europ. Soc. for Hyperthermic Oncology. Abstracts. Graz. Austria. 2005. P. 1–2.
  35. Bing C., Staruch R. M., Tillander M. et al. Drift correction for accurate PRF-shift MR thermometry during mild hyperthermia treatments with MR-HIFU. Int. J. Hyperthermia. 2016. Vol. 32. No. 6. P. 673–687.
  36. Bruggmoser G., Bauchowitz S., Canters R. et al. Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia. Strahlenther. Onkol. 2012. Suppl. 2. Vol. 188. P. 198–211. DOI 10.1007/s00066-012-0176-2.
  37. Kok H.P., Kotte A.N.T.J., Crezee J. Planning, optimisation and evaluation of hyperthermia treatments. Int. J. Hyperthermia. 2017 (in press). Available at: http://dx.doi.org/10.1080/02656736.2017.1295323.
  38. Harima Y., Ohguri T., Imada H. et al. A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer. Int. J. of Hyperthermia. 2016. Vol. 32. No. 7. P. 801–808.
  39. Vasanthan A., Mitsumori M., Park J.H. et al. Regional hyperthermia combined with radiotherapy for uterine cervical cancers: a multi-institutional prospective randomized trial of the international atomic energy agency. Int. J. Radiat. Oncol. Biol. Phys. 2005. Vol. 61. No. 1. P. 145–153.
  40. Konishi F., Furuta K., Kanazawa K. et al. The effect of hyperthermia in the preoperative combined treatment of radiation, hyperthermia and chemotherapy for rectal carcinoma. Jpn. J. Gastroenterol. Surg. 1994. Vol. 27. P. 789–796.
  41. Nagata Y., Okuno Y., Hiraoka M. et al. Radiofreqency hyperthermia for malignant liver tumors. Proc. 7th Int. Congress on Hyperthermic Oncology. Rome. 1996. Vol. 2. P. 28–30.
  42. Kurpeshev O.K., Florovskaya N.Yu. Rezul’taty palliativnoy termoluchevoy terapii metastazov kolorektal’nogo raka v pechen’. Med. radiol. i radiats. bezopasnost’. 2014. Vol. 59. No. 5. P. 32–36. (In Russ.).
  43. Ohguri T., Imada H., Yahara K. et al. Radiotherapy with 8-MHz radiofrequency-capacitive regional hyperthermia for stage III non–small-cell lung cancer: the radiofrequency-output power correlates with the intraesophageal temperature and clinical outcomes. Int. J. Radiat. Oncol. Biol. Phys. 2009. Vol. 73. No. 1. P. 128–135.
  44. Yoshida M., Shioura H., Tomi M. et al. Multimodal combination therapy including hyperthermia for inoperable pancreatic cancer. Proc. 7th Internat. Congress on Hyperthermic Oncology. Rome. 1996. Vol. 2. P. 38–39.
  45. Noh J.M., Kim H.Y., Park H.C. et al. In vivo verification of regional hyperthermia in the liver. Radiat. Oncol. J. 2014. Vol. 32. No. 4. P. 256–261.
  46. Zubarev A.L., Kuril’chik A.A., Kurpeshev O.K et al. Lokal’naya gipertermiya v kombinirovannom lechenii mestnorasprostranennykh sarkom myagkikh tkaney. Sibirskiy onkol. zh. 2015. No. 3. P. 55–60. (In Russ.).
  47. Pankratov V.A., Andreyev V.G., Kurpeshev O.K. et al. Primeneniye termokhimioluchevogo lecheniya u bol’nykh s mestno-rasprostranennym rakom gortani i gortanoglotki. Rossiyskiy onkol. zh. 2006. No. 4. P. 20–23. (In Russ.).
  48. Berdov B.A., Yerygin D.V., Nevol’skikh A.A. et al. Mezhdistsiplinarnyy podkhod v lechenii raka pryamoy kishki. Povolzhskiy onkologicheskiy vestnik. 2015. No. 4. P. 21–28. (In Russ.).
  49. Kurpeshev O.K., Ragulin Yu.A., Mozerov S.A. et al. Vozmozhnosti lokal’noy gipertermii pri lechenii bol’nykh otechnoy formoy raka molochnoy zhelezy. Voprosy onkologii. 2016. Vol. 62. No. 5. P. 680–687. (In Russ.).
  50. Datta N.R., Grobholz R., Puric E. et al. Enhanced tumour regression in a patient of liposarcoma treated with radiotherapy and hyperthermia: Hint for dynamic immunomodulation by hyperthermia. Int. J. Hyperthermia. 2015. Vol. 31. No. 5. P. 574–577. doi: 10.3109/02656736.2015.1033482.
  51. Wust P. Thermotherapy in oncology. 1st ed. - Bremen: UNI-MED. 2016 (UNI-Med Science). 95 pp.
  52. Kok H.P., Crezee J., Franken N.A. et al. Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions. Int. J. Radiat Oncol Biol Phys. 2014. Vol. 88. P. 739–745.
  53. Van der Zee J., Vujaskovic Z., Kondo M., Sugahara T. Part I. Clinical Hyperthermia. The Kadota Fund International Forum 2004 Clinical group consensus. Int. J. Hyperthermia. 2008. Vol. 24. No. 2. P. 111–122.

For citation: Kurpeshev OK, van der Zee J. Locoregional Hyperthermia of Malignant Tumors: Methods, Thermometry, Machines. Medical Radiology and Radiation Safety. 2017;62(5):52-63. Russian. DOI: 10.12737/article_59f30321207ef4.88932385

PDF (RUS) Full-text article (in Russian)

Contact Information

 

46, Zhivopisnaya st., 123098, Moscow, Russia Phone: +7 (499) 190-95-51. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal location

Attendance

2760492
Today
Yesterday
This week
Last week
This month
Last month
For all time
857
2366
18876
18409
68235
75709
2760492
Forecast today
11880

Your IP:216.73.216.35
Visitor Counter

© Журнал "Медицинская радиология и радиационная безопасность" 2020г.

Яндекс.Метрика

Наверх