JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety, 2016, Vol. 61. No. 5. P. 13-26
RADIATION EPIDEMIOLOGY
V. Azizova1, E.S. Grigoryeva1, R. Haylock2, M.V. Bannikova1, M.B. Moseeva1
Risk of Incidence and Mortality from Ischemic Heart Disease in the Cohort of Workers with Chronic Occupational Exposure
1. Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Public Health England, Chilton, UK
ABSTRACT
Purpose: Assessment of incidence and mortality risk from ischemic heart disease (IHD) in relation to radiation (external gamma- and internal alpha-exposure) and non-radiation factors (gender, age, smoking, alcohol consumption, hypertension, increased body mass index).
Material and methods: IHD risk was studied in the cohort of workers of the nuclear enterprise (22377 workers, 25 % - females) with chronic occupational exposure. Relative risks and excess relative risks per unit dose (1 Gray) were calculated based on maximum likelihood using AMFIT module of the EPICURE software. Dose estimates used in analyses were provided by an updated ‘Mayak Worker Dosimetry System-2008’.
Results: A significant linear association of IHD incidence risk with total dose from external gamma-rays was observed after having adjusted for non-radiation factors and dose from internal radiation (ERR/Gy = 0.10; 95 % CI: 0.04, 0.17). No significant association of IHD mortality risk was revealed after having adjusted for non-radiation factors and dose from internal alpha-radiation (ERR/Gy = 0.06; 95 % CI: < 0, 0.15). No association of IHD incidence risk with total absorbed dose from internal alpha-radiation to the liver after having adjusted for non-radiation factors and external gamma-dose (ERR/Gy = 0.02; 95 % CI: n/a, 0,10). Statistically significant linear association of IHD mortality risk with total absorbed dose from internal alpha-radiation to the liver was revealed after having adjusted for non-radiation factors and external gamma-dose (ERR/Gy = 0.21; 95 % CI: 0.01, 0.58).
Conclusion: This study provides strong evidence of the association of the ischemic heart disease incidence risk with external gamma-ray exposure and some evidence of the association of the mortality risk for ischemic heart disease with internal alpha-radiation exposure.
Key words: risk, mortality, incidence, ischemic heart disease, Mayak PA, gamma-ray, alpha-radiation, occupational exposure
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For citation: Azizova TV, Grigoryeva ES, Haylock R, Bannikova MV, Moseeva MB. The Risk of Incidence and Mortality from Ischemic Heart Disease in the Cohort of Workers with Chronic Occupational Exposure. Medical Radiology and Radiation Safety. 2016;61(5):13-26. Russian.
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