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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Radiology and Radiation Safety. 2016. Vol. 61. No. 5. P. 59-64
RADIATION PHYSICS, TECHNOLOGY AND DOSIMETRY
S.E. Ulianenko1, A.N. Soloviev1,2, V.M. Lityaev1, V.V. Fedorov1, S.N. Koryakin1
Monte-Carlo Simulation of Photon and Proton Capture Therapy with Gold Compounds
1. A.F. Tsyb Medical Radiological Research Centre, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Institute for High Energy Physics, Protvino, Russia
ABSTRACT
Purpose: Theoretical and numerical simulation using Monte-Carlo method to assess the proof-of-concept mechanism of photon and proton capture therapy with gold compounds and solutions.
Material and methods: The simulation of photon capture therapy is done with MCNP code, the proton capture therapy using Geant4 framework and our own developed software methods C++ and Python. Both simulations carried with tissue-equivalent phantom. The number of additional simulations was required to find the theoretical mechanism of proton capture therapy.
Results: The 10 mg per 1 g Au-based tissue compound resulted in doubling the absorbed dose value mainly due to interaction γ-quanta with electron shells of atoms and induced cascade of electrons. The 1 mg per 1 g Au-based tissue compound for the proton capture therapy may result in qualitive changes in absorbed dose distribution, resulted in 15 % few dose for 50 MeV proton, 15 % higher dose for 150-250 MeV protons and same dose for 100 MeV protons. The additional experiments and simulations may be further required for proper investigation of such effects. And also with a proton energy increase there is a decrease of number of elastic collisions with gold compounds, which demonstrates significant reduction of the reaction cross section.
Conclusion: The Au-based solutions may be kindly introduced into clinical practice for the photon capture therapy, on the other side, the proton capture therapy are yet to be implemented under both the physical interaction models improve as well as qualitive assessment of radiobiology effect.
Key words: Monte-Carlo method, photon capture therapy, proton capture therapy, gold compounds
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For citation: Ulianenko SE, Soloviev AN, Lityaev VM, Fedorov VV, Koryakin SN. Monte-Carlo Simulation of Photon and Proton Capture Therapy with Gold Compounds. Medical Radiology and Radiation Safety. 2016;61(5):59-64. Russian.
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