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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 59-63
NUCLEAR MEDICINE
T.M. Geliashvili, A.V. Vazhenin, E.B. Vasil’eva, N.G. Afanas’eva
Experience of Use 18F-FDG PET/CT in Detecting Tumor Recurrence and Metastasis of Differentiated Thyroid Cancer
Chelyabinsk Regional Clinical Oncology Center, Chelyabinsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To investigate the diagnostic accuracy and impact in patients management of the integrated 18F-FDG PET/CT modality in patients with differentiated thyroid cancer.
Material and methods: A retrospective review of patients who underwent PET/CT scans were performed. The study included patients with elevated thyroglobulin levels during the postoperative radioiodine ablation course or after completion of the combination treatment at follow-up of DTC.
Results: PET/CT was positive in 39 cases (64 %), 18 (46.1 %) of which was loco-regional recurrence, 12 (30.8 %) - distant metastases and the combination of loco-regional recurrence with distant metastases 9 (23.1 %). The negative result was obtained for 22 (36 %) PET/CT study (without pathology 7 (31.8 %), questionable results 15 (68.2 %)). Totally 27 (44.3 %) loco-regional recurrences diagnosed with PET / CT, and by 131I whole body scan (WBS) - 14 (23 %)). 15 surgical interventions for loco-regional recurrence were achieved. Diagnosis of recurrence in 13 cases (87 %) was proved historically. In 2 (13 %) patients we received a false-positive results of PET/CT. In 21 (34.4 %) of PET/CT study distant metastases were revealed (in the lungs and/or mediastinum - 14 (67 %), in bone 3 (14 %), a combination of several sites of distant metastases 4 (19 %)). In 11 of 14 cases (78.6 %) lung metastases were revealed exclusively in CT mode. Mediastinal lymph node metastases appeared all PET-positive 6 (100 %). Metastases in other organs were detected in 7 cases out of which all bone metastases were PET positive (6 cases); soft tissue metastases identified by CT mode in 1 case. By planar WBS detected distant metastases in 18 cases (29.5 %).
Conclusions: PET/CT showed higher sensitivity in the detection of the neck lymph nodes metastases (44.3 %) than WBS (23 %). With regard to detection of distant metastases, PET/CT and WBS showed similar sensitivity (34.5 % and 29.5 %, respectively). Through a combination of modes of PET with CT mode the sensitivity of PET/CT in detection of metastases in the lungs increases greatly.
Key words18: F-FDG PET/CT, differentiated thyroid cancer, whole body scan, loco-regional recurrence, distant metastases
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For citation: Geliashvili TM, Vazhenin AV, Vasil'eva EB, Afanas'eva NG. Experience of Use 18F-FDG PET/CT in Detecting Tumor Recurrence and Metastasis of Differentiated Thyroid Cancer. Medical Radiology and Radiation Safety. 2016;61(4):59-63. Russian.
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