SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 5-19

RADIATION BIOLOGY

A.N. Koterov, L.N. Ushenkova, A.P. Biryukov, A.S. Samoilov

RET/PTC Gene Rearrangements Frequency in Papillary Thyroid Carcinoma Worldwide Depending on Time After Chernobyl Nuclear Power Plant Accident (Pooled-Analysis)

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Results of pooled-analysis of primary data in the database formed from molecular epidemiological sources on RET/PTC generearrangements frequency in papillary thyroid carcinoma developed spontaneously and after Chernobyl nuclear power plant accident showed declined chronological trends for RET/PTC1, RET/PTC3 and RET/PTC after the incident separately for cohorts from Europe, USA + Canada and the Asia-Pacific region have been demonstrated. The above trend for RET/PTC3 and RET/PTC in total was similar to trends observed in carcinomas of Chernobyl etiology (Belarus, Russia and Ukraine), although there was no apparent time dependence for RET/PTC1 level in this case. Observed trends could not be connected to any chronological changes in the degree of carcinoma differentiation or age factor for tumor. As chronological changes of RET/PTC frequency in carcinomas in different continents and regions can not be explained by the radiation factor of the Chernobyl accident, it was concluded about the predominant contribution of the ‘human factor’ associated with ‘overestimation’ and ‘overdiagnosis’ of early forms of thyroid tumors in connection with increased vigilance after the Chernobyl accident. Apparently, these factors, along with improvement of instrumental methods at that time, coupled with the ‘aggressive surgery’, took place worldwide resulting in detection of early forms of the occult carcinomas and microcarcinomas. The frequency of RET/PTC in such tumors is higher than in conventional tumors. The frequence of these subjective factors is likely to decrease with time from the date of the Chernobyl accident.

Key words: pooled-analysis, RET/PTC gene rearrangements, papillary thyroid carcinoma, the time after the Chernobyl accident, overestimation

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For citation: Koterov AN, Ushenkova LN, Biryukov AP, Samoilov AS. RET/PTC Gene Rearrangements Frequency in Papillary Thyroid Carcinoma Worldwide Depending on Time After Chernobyl Nuclear Power Plant Accident (Pooled-Analysis). Medical Radiology and Radiation Safety. 2016;61(2):5-19. Russian.

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