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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 65-69
REVIEW
O.K. Kurpeshev1, N.Yu. Florovskaiya2
The Results of Palliative Treatment of Colorectal Cancer Metastases to the Liver by Thermoradiotherapy
1.A.F. Tsyb Medical Radiological Research Centre, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Murmansk Regional Oncology Center, Murmansk, Russia
ABSTRACT
Purpose: Studying of efficiency of thermoradiation therapy in palliative treatment of patients with metastasises (MTS) of a colorectal cancer (CRC) in a liver.
Material and methods: Thermoradiotherapy therapy (TRT), held on 23 patients with CRC to the liver mts. Comparison group was 28 patients who underwent only external beam radiotherapy (EBRT). Locoregional hyperthermia of the liver was performed by a capacitive method at a temperature of 41-44 °C MTS and duration of exposure of 40 to 90 min. The total tumor dose EBRT in total liver irradiation was 20-26 Gy, subtotal - 28-36 Gy. The results of treatment were assessed by direct effect and overall survival according to stage (st.) liver disease.
Results: In the control group immediate therapeutic effect was detected in 13 (46 %) patients in the study - 17 (74 %), p = 0.044. The tendency to a difference (p = 0,06-0,07) in overall survival between subgroups of patients was with 2 and 3 stage liver disease. Patients with 2 stage median survival after EBRT were 7 months., TRT - 9 months, 3 stage - 3 and 4 months respectively.
Conclusion: The findings suggest the need for further research of thermoradiotherapy for the palliative treatment of patients with colorectal cancer to the liver MTS.
Key words: hyperthermia, radiation therapy, colorectal cancer, metastases in the liver
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For citation: Kurpeshev OK, Florovskaiya NYu. The Results of Palliative Treatment of Colorectal Cancer Metastases to the Liver by Thermoradiotherapy. Medical Radiology and Radiation Safety. 2016;61(2):65-9. Russian.
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