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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 1. P. 11-16
RADIATION BIOLOGY
V.Yu. Soloviev, A.E. Baranov
The Model Post-Radiation Kinetics of Cell Populations in Bone Marrow Syndrome
A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Development of a mathematical model of recovery number of stem cell after acute total body irradiation.
Material and methods: The object of study is the data from a database of human acute radiation syndrome of A.I. Burnasyan Federal Medical Biophysical Center of FMBA on the post-radiation dynamics of the concentration of granulocytes in the peripheral blood of the victims of the Chernobyl accident in 1986.
Results: A model with mathematical description for the evaluation of post-radiation dynamics of stem cell pool and formed elements (granulocytes) in human peripheral blood is proposed. It is shown that the hypothetical idea of the trigger mechanism of the inclusion of several different modes of post-radiation recovery of stem cells pool and the existence of so-called critical level of the prohibition on differentiation does not contradict to the observed pattern of clinical data. A hypothesis is proposed about the possibility of external interference in the biological program of natural post-radiation recovery. It can lead to a less pronounced acute period of bone marrow syndrome in a dose range of 3-5 Gy. It may cause some reduction in agranulocytosis duration (at 2-4 days).
Conclusion: If the fundamental theoretical constructions are correct, we hope to find out some targeted therapies that can to some extent block the access to the differentiation of hematopoietic stem cells in a certain way and change the course of the clinical picture of bone marrow syndrome and, consequently, reduce some risk of death with severe and extremely severe bone marrow syndrome.
Key words: bone marrow syndrome, cell populations, granulocytes, model, gamma irradiation, dose
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For citation: Soloviev VYu, Baranov AE. The Model Post-Radiation Kinetics of Cell Populations in Bone Marrow Syndrome. Medical Radiology and Radiation Safety. 2016;61(1):11-6. Russian.
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