JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 5-11
RADIATION BIOLOGY
A.A. Ivanov1,2, I.E. Andrianova1, T.M. Bulynina1,2, O.V. Dorozhkina1,2, V.N. Mal’tsev1, N.M. Stavrakova1, G.A. Shal’nova1, A.Yu. Bushmanov1
The Pharmacological Effects of Melanin in the Irradiated Mice
1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Joint Institute for Nuclear Research, Dubna, Russia
ABSTRACT
Purpose: Investigation of the melanin efficiency administered to mice after irradiation at different doses.
Material and methods: The bone marrow form of the acute radiation syndrome in mice CD-1 was reconstructed by single or fractionated whole body irradiation with gamma- or X-rays. Phytomelanin water-soluble was given with water ad libitum from the first to the 30-th day after irradiation.
Results: It was shown that melanin was given after the acute exposure to ionizing radiation in doses 6.0-7.5 Gy decreased the lethal outcomes in all groups of mice. The survival melanin treated mice increased by 13-18 % as compared with control. After fractionated exposure (1 Gy daily, total dose 10 Gy) melanin produced 100 % therapeutic effect when the survival of control mice was 43.7 %. Melanin treated mice has demonstrated that body weight loss and the frequency test for bacteriuria were lower than in control. Moreover in mice which received melanin a more pronounced restoration motoric and searching activity had been observed.
Conclusion: According our experimental data melanin given “per os” after irradiation produced a marked therapeutic effect.
Key words: phytomelanin, X-rays and gamma-irradiation, single and fractionated, survival, bacteriuria, behavioral reactions, experimental therapy
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For citation: Ivanov AA, Andrianova IE, Bulynina TM, Dorozhkina OV, Mal’tsev VN, Stavrakova NM, Shal’nova GA, Bushmanov AYu. The Pharmacological Effects of Melanin in the Irradiated Mice. Medical Radiology and Radiation Safety. 2015;60(5):5-11. Russian.
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