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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 31-39
RADIATION EPIDEMIOLOGY
E.I. Rabinovich, V.F. Obesnyuk, S.V. Povolotskaja, S.N. Sokolova, V.A. Turdakova
Impact Assessment of Carcinogenic Factors on the Atrophic Gastritis in the Cohort of Workers of the Nuclear Facility
Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Research of exogenous and endogenous risk factors of atrophic gastritis (AG) appearing among the workers of atomic enterprise “Mayak”.
Material and methods: 542 individuals were enrolled into research, 438 of them are workers of “Mayak”. The main health hazards for the “Mayak” personnel are possible long-term external γ-exposure and (or) internal exposure with α-particles, as well as the effects of ecotoxic chemicals. The control group consisted of 104 individuals never exposed to any occupational factors. Functional status of the stomach was investigated by GastroPanel test-system (Biohit, Finland). Assessment of statistical significance of the differences was performed on χ2 statistics calculating the p-value as well as applying contingency tables with further calculations of relative risk.
Results and conclusions: According to the results the incidence of atrophic gastritis among Mayak PA workers exceeded those among the individuals never exposed to harmful occupational factors (14.8 % against 4.8 %; p < 0.05). Statistical analysis showed that both occupational and non-occupational factors affect the development of AG. Thus, a significant increase of relative risk of atrophic gastritis was stated in relation to external exposure with doses equal to 150 mGy and higher (RR = 3.62, 90 % CI 1.53-9.12) in relation to influence of inorganic compounds (RR = 1.58 , 90 % CI 1.04-2.33). Family anamnesis of stomach cancer (RR = 2.27, 90 % CI 1.29-3.57), non-ulcerous gastritis (RR = 1.68, 90 % CI 1.08-2.5), female gender (RR = 1.53, 90 % CI 1.05-2.21) had predisposing influence on development of AG. At the same time a statistically significant deterrent effects for development of AG was detected for smoking factor (RR = 0.51, 90 % CI 0.31-0.78). The data obtained are of great importance, and the question on purposeful detection of AG among the workers exposed to occupational radiation and chemical factors arises. Taking into account the effects of non-occupational carcinogenic factors an elaboration of an individual program of cancer prevention appears.
Key words: radiation exposure, carcinogenic factors, gastric cancer, atrophic gastritis, “Gastro Panel”
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For citation: Rabinovich EI, Obesnyuk VF, Povolotskaja SV, Sokolova SN, Turdakova V.A. Impact Assessment of Carcinogenic Factors on the Atrophic Gastritis in the Cohort of Workers of the Nuclear Facility. Medical Radiology and Radiation Safety. 2015;60(5):31-9. Russian.
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