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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 4. P. 5-11
RADIATION BIOLOGY
S.V. Osovets
Revisiting the Theory of Radiation Injury and Recovery
Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To develop an alternative approach (regarding the Blair-Davidson theory) to quantitative description of radiation injury and recovery processes based on common radiobiological patterns typical for deterministic effects.
Results: Based on quantitative patterns of deterministic effects a new distribution of recovery potential (U) following a whole body irradiation of mammals was estimated:
where T was a duration of exposure, T1/2 was a half recovery period during an exposure. U value ranged from 0 to 1 with T value ranging from 0 to T1/2. An equation of a residual dose De (absolute injury) at double external gamma exposure was derived:
where D was a dose from the first exposure event, t was a time interval between two sequential radiation exposures, t 1/2 was a half recovery period after the irradiation. A suggested relation between De and t was based on the assumption of the similarity of mathematical representations of recovery processes during irradiation and postirradiation periods. Additionally, a new relationship between a median dose D50 and duration of exposure T was obtained:
where θ∞ and θ1 were parameters of the mathematical model. The estimated relationships were tested using experimental data on acute X-ray irradiation of mice.
Conclusions: Based on the development of fundamental mathematical models used for quantitative description of deterministic effects, an alternative approach to modeling the processes of mammalian radiation injury and recovery was stated and considerably advanced compared to the original Blair-Davidson theory. Mathematical representations of recovery processes at external whole body exposure were shown to be similar, but the recovery rate for irradiation period differed from that for post-irradiation one. New distributions and equations were derived to provide an adequate description of the above mentioned ionizing radiation health effects in mammals. Further development of the theory is needed to practically apply it to radiology, radiobiology and radiation safety.
Key words: Blair-Davidson theory, radiation injury and recovery, external gamma-ray exposure, deterministic effects, mathematical models
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For citation: Osovets SV. Revisiting the Theory of Radiation Injury and Recovery. Medical Radiology and Radiation Safety. 2015;60(4):5-11. Russian.
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