JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 4. P. 12-18
RADIATION BIOLOGY
V.P. Fyodorov, O.P. Gundarova, N.V. Sgibneva, N.V. Maslov
Radiation-Induced and Age-Related Changes in Cerebellar Neurons
N.N. Burdenko State Medical Academy, Voronezh, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To explore the changes in the structural and functional organization of the cerebellar cortex neurons throughout the period of post-radiation in comparison with the age adsjusted control.
Material and methods: White male rats (120 animals) irradiated on the Hizatron 60Co γ-rays single dose of 0.1; 0.2; 0.5 and 1.0 Gy with a dose rate of 0.5 Gy/h. Material taken away by one day, 6, 12 and 18 months after irradiation. The dynamics of tinctorial properties of neurons, their morphometric parameters, amount of protein, and nucleic acids examined.
Results: The correlation between different types of neurons in animals of biological control has changed throughout life and generally reflected their different functional status. By the end of the period of post-radiation, the number of decaying neurons was increased. In irradiated animals the decrease of the number of normochromic neurons at a dose of 0.1 Gy was found day after the irradiation. In 6 months, the greatest decrease in the number of normochromic neurons was observed at doses of 0.1 and 1.0 Gy due to the increase of nerve cells with destructive changes. At the end of post-radiation period, the number of nerve cells corresponded to the age adjusted control, and to the increase of the number of destructive cells at a dose of 0.5 Gy. Within the life span of both the control and irradiated animals, the stochastic variation of morphometric parameters of all components of neurons was observed, especially in their bodies and in the cytoplasm, and to a lesser extent in the nucleus and nucleolus. The protein content in nerve cells, nuclear DNA, post- phase changed RNA nucleoli has been reduced at the end of the observation, and the RNA in the cytoplasm of neurons has decreased slightly.
Conclusion: The nervous system has certain sensitivity to the radiation factor. Revealed changes are reversible and, under certain conditions can cause various forms of alternative or adaptive changes. All kinds of changes occurred in both the control and experimental groups are differentin percentage only.
Key words: neurons, cerebellum, ionizing radiation, nejromorfologikal effects
REFERENCES
- Gundarova O.P., Fedorov V.P., Afanas'ev R.V. Otsenka psikhonevrologicheskogo statusa likvidatorov radiatsionnykh avarii. Voronezh: «Nauchnaya kniga». 2012. 232 p. (In Russ.).
- Gus'kova A.K. Osnovnye itogi i istochniki oshibok v ustanovlenii radiatsionnogo etiopatogeneza nevrologicheskikh sindromov i simptomov. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2007. No. 12. P. 66–70. (In Russ.).
- Torubarov F.S., Blagoveshchenskaya V.V., Chesalin P.V. Sostoyanie nervnoi sistemy u postradavshikh pri avarii na Chernobyl'skoi atomnoi elektrostantsii. Zhurnal nevropatologii i psikhiatrii im. S.S. Korsakova. 1989. Vol. 89. No. 2. P. 48–52. (In Russ.).
- Torubarov F.S., Zvereva Z.F. Nevrologicheskie aspekty ostroi luchevoi bolezni cheloveka (klinicheskie nablyudeniya). Moscow: FMBTs im. A.I. Burnazyana. 2009. 208 p. (In Russ.).
- Ushakov I.B., Arlashchenko N.I., Soldatov S.K. Ekologiya cheloveka posle Chernobyl'skoi katastrofy: radiatsionnyi ekologicheskii stress i zdorov'e cheloveka. Voronezh: VGU. 2001. 723 p. (In Russ.).
- Bekhtereva N.P. Zdorovyi i bol'noi mozg cheloveka. Leningrad: Nauka. 1988. 262 p. (In Russ.).
- Grigor'ev Yu.G. Somaticheskie effekty khronicheskogo gamma-oblucheniya. Moscow: Energoatomizdat. 1986. 195 p. (In Russ.).
- Sevan'kaev A.V., Dedenkov A.N. Aktual'nye problemy sovremennoi radiobiologii v svete otsenki i prognozirovaniya posledstvii avarii na Chernobyl'skoi AES. Radiobiologiya. 1990. Vol. 30. No. 5. P. 579–583. (In Russ.).
- Fedorov V.P., Petrov A.V., Stepanyan N.A. Ekologicheskaya neiromorfologiya. Klassifikatsiya tipovykh form morfologicheskoi izmenchivosti TsNS pri deistvii antropogennykh faktorov. Zhurnal teor. i prakt. meditsiny. 2003. Vol. 1. No. 1. P. 62–66. (In Russ.).
- Ushakov I.B., Fedorov V.P., Zuev V.G. Neiromorfologicheskie effekty elektromagnitnykh izluchenii. Voronezh, Tsentral'no-Chernozemnoe knizhnoe publ. 2007. 287 p. (In Russ.).
- Maslov N.V., Fedorov V.P., Afanas'ev R.V. Morfofunktsional'noe sostoyanie temennoi kory pri deistvii malykh doz ioniziruyushchego izlucheniya. Voronezh: «Nauchnaya kniga». 2012.228 p. (In Russ.).
- Sgibneva N.V., Fedorov V.P. Morfofunktsional'noe sostoyanie sensomotornoi kory posle malykh radiatsionnykh vozdeistvii. Voronezh: «Nauchnaya kniga». 2013. 252 p. (In Russ.).
- Fedorenko B.S. Morfologicheskie i tsitogeneticheskie narusheniya u krys, nakhodyashchikhsya v usloviyakh povyshennogo radiatsionnogo fona na protyazhenii dlitel'nogo vremeni. Aviakosm. i ekolog. meditsina. 2002. Vol. 36. No. 1. P. 21–22. (In Russ.).
- Karpov V.N., Ushakov I.B., Davydov B.I. Effektivnaya doza kak razdrazhayushchee vozdeistvie pri fraktsionirovannom γ-obluchenii. Radiobiologiya. 1990. Vol. 30. No. 1. P. 107–112. (In Russ.).
- Aleksanin S.S. Osobennosti funktsional'nogo sostoyaniya tsentral'noi nervnoi sistemy u uchastnikov likvidatsii posledstvii avarii na Chernobyl'skoi AES. Medical Radiology and Radiation Safety. 2007. Vol. 52. No. 5. P. 5–11. (In Russ.).
For citation: Fyodorov VP, Gundarova OP, Sgibneva NV, Maslov NV. Radiation-Induced and Age-Related Changes in Cerebellar Neurons.. Medical Radiology and Radiation Safety. 2015;60(4):12-8. Russian.
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