JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 4. P. 19-26
RADIATION SAFETY
A.S. Lunev, O.E. Klementyeva, G.E. Kodina
Computational Research of Prognosis Values of Absorbed Doses for Pre-Clinical Safety Evaluation of Radiopharmaceutical 68Ga-Citrate
A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: 68Ga-citrate is a prospective radiopharmaceutical for PET-imaging of the inflammation. The use of radiopharmaceuticals is assumed with risk of various complications directly related to ionizing radiation. Therefore there is a need of the information on doses conducted to the pathological locus, organs and tissues and the whole organism in the process of the development and pre-clinical study of new radiopharmaceuticals. It is important for the safety assessment of radiopharmaceuticals.
Material and methods: 68Ga-citrate is the object of the study. Nonlinear rats’ females (181.9 ± 16.0 g) with model of soft tissue inflammation conpose the study material. Absorbed and effective doses of 68Ga-citrate were calculated in organs and tissues of rats according to the rats’ body distribution and extrapolated to human body.
Results: OLINDA/EXM 1.0 software was used for the calculation of doses. The highest absorbed doses were recorded as follows: 18.4 mGy in urinary bladder, 11.6 mGy in kidneys and 23.7 mGy in the intestine. Effective dose is 14.9 mSv. Such doses (less than 100 mSv) according ICRP and UNSCEAR publications should not be included in the irradiation damage assessment. Specific absorbed dose of the pathological area (model of aseptic inflammation) is 4.9 ± 4.3 mGy/MBq.
Conclusion: The results of dosimetry evaluation have determined the high safety level of 68Ga-citrate radiopharmaceutical for PET-imaging of the inflammation.
Key words: 68Ga-citrate, OLINDA/EXM 1.0 software, dosimetry
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For citation: Lunev AS, Klementyeva OE, Kodina GE. Computational Research of Prognosis Values of Absorbed Doses for Pre-Clinical Safety Evaluation of Radiopharmaceutical 68Ga-Citrate. Medical Radiology and Radiation Safety. 2015;60(4):19-26. Russian.
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