SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 4. P. 27-35

RADIATION SAFETY

B.Ja. Narkevich1,2, Yu.V. Lysak3,4

Radiation Safety in the Ambulatory Use of Therapeutic Radiopharmaceuticals<

1. Institute of Medical Physics and Engineering, Moscow, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. N.N. Blokhin Cancer Research Center of RAMS, Moscow; 3. National Research Nuclear University MEPhI, Moscow; 4. Russian Scientific Center of Radiology and Nuclear Medicine, Moscow

ABSTRACT

Purpose: To determine the feasibility of the use of therapeutic radiopharmaceuticals (RN) in ambulatory mode without hospitalization for radionuclide therapy.

Material and methods: We performed computational studies of radiation safety of individuals from the population being in contact with the patient, which received particular therapeutic radiopharmaceuticals labeled with one of 19 β-γ-emitting radionuclides or one of 4 β-emitting radionuclides or one of 6 α-β-γ-emitting radionuclides in ambulatory mode. Criterion validity outpatient regimen is the effective dose of external exposure of these persons. Based on the dose limit for the population installed by NRB-99/2009, the maximum permissible activity of these radionuclides for various geometries and standard time exposure scenario was calculated.

Results and conclusions: It is shown that even for conservative exposure conditions outpatient mode of application is quite valid for all therapeutic radiopharmaceuticals labeled with any of these radionuclides, with the exception only for radiopharmaceuticals labeled with 131I.

Key words: radionuclide therapy, therapeutic radiopharmaceuticals, outpatient mode of application, radiation safety

REFERENCES

  1. Normy radiatsionnoi bezopasnosti (NRB-99/2009). SP 2.6.1.2523-09. (In Russ.).
  2. Release of Patients after Therapy with Unsealed Radionuclides. Recommendation of the ICRP Publication 94. Annals of the ICRP. 2004. Vol. 34. No. 2. 80 p.
  3. IAEA Publication 1417. Release of Patients after Radionuclide Therapy. Safety Reports Series No. 63. IAEA, Vienna. 2009.
  4. Balonov M.I., Golikov V.Yu., Zvonova I.A. Radiologicheskie kriterii vypiski patsienta iz kliniki posle radionuklidnoi terapii ili brakhiterapii s implantatsiei zakrytykh istochnikov // Radiatsionnaya gigiena. 2009. Vol. 2. No. 4. P. 5-9. (In Russ.).
  5. Narkevich B.Ya., Zinov'eva N.P. Urovni oblucheniya otdel'nykh lits iz naseleniya ot patsientov s vvedennymi radiofarmpreparatami. Medical Radiology and Radiation Safety. 2002. Vol. 47. No. 1. P. 27-33. (In Russ.).
  6. Shishkanov N.G., Bakun Yu.M., Roziev R.A. O radiatsionnoi bezopasnosti otdel nykh lits iz naseleniya pri obshchenii s patsientami, proshedshimi kurs radioiodoterapii. Medical Radiology and Radiation Safety. 2001. Vol. 46. No. 5. P. 34-46. (In Russ.).
  7. Narkevich B.Ya., Shiryaev S.V., Klepov A.N., Lysak Yu.V. Radiatsionno-gigienicheskoe obosnovanie radionuklidnoi terapii v ambulatornom rezhime. Radiatsionnaya gigiena. 2014. No. 2. P. 26-38. (In Russ.).
  8. Consolidated Guidance about Materials Licensees. Rep. NUREG-1556: Nuclear Regulatory Commission. Washington, DC, 2008. Vol. 9. 28 p.
  9. ICRU Report 57. Conversion Coefficients for Use in Radiological Protection against External Radiation. 1998. 137 p.
  10. Gusev N.G., Kovalev E.E., Osanov D.P., Popov V.I. Zashchita ot izlucheniya protyazhennykh istochnikov. Moscow: Gosatomizdat. 1961. 250 p. (In Russ.).
  11. Mashkovich V.P., Kudryavtseva A.V. Zashchita ot ioniziruyushchikh izluchenii: spravochnik. Moscow: Energoatomizdat. 1995. 496 p. (In Russ.).
  12. ICRP Publication 107. Nuclear Decay Data for Dosimetric Calculations. Annals of the ICRP. Vol. 38. No. 3. P. 7-96.
  13. Neves M., Teixeira F.C., Antunes I. et al. Chemical and biological evaluation of 153Sm and 46/47Sc complexes of indazolebisphosphonates for targeted radiotherapy. Appl. Radiat. Isotopes. 2011. Vol. 69. No. 1. P. 80-84.
  14. Novak-Hofer I., Schubiger P.A. Copper-67 as a therapeutic nuclide for radimmunotherapy. Eur. J. Nucl. Med. Mol. Imaging, 2002. Vol. 29. No. 6. P. 821-830.
  15. Lewington V.J. Bone-seeking radionuclides for therapy. J. Nucl. Med. 2005. Vol. 46. No. 1. Suppl. P. 38S-47S.
  16. Fondell A. Two-step targeting for effective radionuclide therapy. Preclinical evaluation of 125I-labelling anthracycline delivered by tumor targeting liposomes. Dis. Ph.D., Uppsala Univ. 2011.
  17. Gerard S.K., Park H.M. 131I dosimetry and thyroid stunning. J. Nucl. Med. 2003. Vol. 44. No. 12. P. 2039-2040.
  18. Pinch C., Pilger A., Schwameis E. et al. Radiation synovectomy using 165Dy ferric-hydroxide and oxidative DNA damage in patients with different types of arthritis. J. Nucl. Med. 2000. Vol. 41. No. 2. P. 250-257.
  19. Valkema R., deJong M., Bakker W.H. et al. Phase I study of peptide receptor radionuclide therapy with [111In-DTPA]octreotide: the Rotterdam experience. Seminars Nucl. Med. 2002. Vol. 32. No. 2. P. 110-122.
  20. Giralt S., Bensinger W., Goodman N. et al. 166Ho-DOTPM plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: results of two phase 1/2 trials. Blood. 2003, 102. No. 7. P. 2684-2691.
  21. Das T., Chakraborty S., Sarma H.D. et al. 170Tm-EDTMP: a potential cost-effective alternative 89SrCl2 for bone pain palliation. Nucl. Med. Biol. 2009. Vol. 36. No. 5. P. 561-568.
  22. Ando A., Takeshita M., Ando I. et al. Study of subcellular distribution of 169Yb and 111In in tumor and liver. Radioisotopes, 1977. Vol. 26. No. 3. P. 169-174.
  23. Chakraborty S., Das T., Banerjee Sh. et al. 175Yb labeled hydroxyapatite: a potential agent for use in radiation synovectomy of small joints. Nucl. Med. Biol. 2006. Vol. 33. No. 4. P. 585-591.
  24. Bakker W.H., Breeman N.A., Kwekkeboom D.J. et al. Practical aspects of peptide receptor radionuclide therapy 177Lu-[DOTA0,Tyr3]octreotat. Q. J. Nucl. Med. Imaging, 2006. Vol. 50. No. 4. P. 265-271.
  25. Kannan R., Zambre A., Chanda N. et al. Functionalized radioactive gold nanoparticles in tumor therapy. Nanomedicine and Nanobiotechnology. 2011. Vol. 4. No. 1. P. 42-51.
  26. Abrams P.G., Fritzberg A.R. Radioimmunotherapy of Cancer. New York: CRC Press. 2000. 416 p.
  27. Zalutsky M.R., Reardon D.A, Bigner D.D. Targeted α-particle radiotherapy with 211At labeled monoclonal antibodies. Nucl. Med. Biol. 2007. Vol. 34. No. 7. P. 779-785.
  28. Miao Y., Hylarides M., Fisher D.R. et al. Melanoma therapy via peptide-targeted alpha radiation. Clin. Cancer Res. 2005. Vol. 11. No. 15. P. 5615-5621.
  29. Yong K., Brechbiel M.W. Towards of 212Pb as a clinical therapeutic; getting the lead in. Dalton Trans. 2011. Vol. 40. No. 23. P. 6068-6076.
  30. Sartor O., Maalouf B.N., Hauck C.R., Macklis R.M. Targeted use of alpha particles: current status in cancer Nucl. Med. Radiat. Ther. 2012. Vol. 3. No. 4. P. 1000136, 8 p.
  31. Miederer M., Scheinberg D.A., McDevitt M.R. Realizing the potential of actinium-225 radionuclide generator in targeted alpha-particle therapy application. Adv. Drug Deliv. Rev. 2008. Vol. 60. No. 12. P. 1371-1382.
  32. Allen B.J. Systemic targeted alpha radiotherapy for cancer. Radiats. onkologiya i yadernaya meditsina. 2013. No. 2. P. 82-98.
  33. Mukhopadhyay B., Mukhopadhyay K. Application of the carrier free radioisotopes of second transition series elements in the field of nuclear medicine. J. Nucl. Med. Ther. 2011. Vol. 2. No. 2. P. 1000115, 9 p.
  34. Hillegonds D.J., Franklin S., Shelton D.K. et al. The management of painful bone metastases with an emphasis on radionuclide therapy. J. Natl. Med. Assoc. 2007. Vol. 99. No. 7. P. 785-794.
  35. Kucuk O.N., Soydal C., Lacin S. et al. Selective intraarterial radionuclide therapy with 90Y microspheres for unresectable primery and metastatic liver tumors. World J. Surg. Oncol. 2011. Vol. 9. No. 1. P. 86-96.
  36. Rajendran J.G. Therapeutic Radioisotopes. In: Nuclear Medicine Therapy. Ed. by F. Eary, W. Brenner. New York, London: Informa Healthcare. 2007. 195 p.
  37. Ehrhardt G.I., Volkert W., Goekeler W.F., Kapsch D.N. A new Cd-115 leads to In-115m radionuclide generator. J. Nucl. Med. 1983. Vol. 24. No. 4. P. 342-352.
  38. Khabriev R.U. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novykh form farmakologicheskikh veshchestv. Moscow: Meditsina. 2005. (In Russ.).
  39. Lubin E. Definitive improvement in the approach to the treated patient as a radioactive source. J. Nucl. Med. 2002. Vol. 43. P. 364-365.
  40. Gigienicheskie trebovaniya po obespecheniyu radiatsionnoi bezopasnosti pri provedenii luchevoi terapii s pomoshch yu otkrytykh radionuklidnykh istochnikov. SanPiN 2.6.1.2368-08. Moscow, Federal nyi tsentr gigieny i epidemiologii Rospotrebnadzora. 2009. 74 p. (In Russ.).
  41. Osnovnye sanitarnye pravila obespecheniya radiatsionnoi bezopasnosti OSPORB 99/2010. Sanitarnye pravila i normativy SP 2.6.1.2612-10. (v red. izmenenii No. 1, utv. postanovleniem Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 16.09.2013 No. 43). (In Russ.).
  42. Neves M., Kling A., Oliveira A. Radionuclides used for therapy and suggestion for new candidates. J. Radioanalyt. Nucl. Chem. 2005. Vol. 266. No. 3. P. 377-384.

For citation: Narkevich BJa, Lysak YuV. Radiation Safety in the Ambulatory Use of Therapeutic Radiopharmaceuticals. Medical Radiology and Radiation Safety. 2015;60(4):27-35. Russian.

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