JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 2. P. 60-65
NUCLEAR MEDICINE
V.F. Demin1,2, A.A. Antsiferova2, Yu.P. Buzulukov2, V.A. Demin2,1, V.Yu. Soloviev1
Nuclear Physical Method for the Detection of Chemical Elements in Biological and Other Samples Using Activation by Charged Particles*
1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. National Research Center “Kurchatov Institute”, Moscow, Russia
* Applied research is carried out with financial support from the state on behalf of the Russian Ministry of Education and Science (RFMEFI60414X0114)
ABSTRACT
Purpose: To develop a method of radioactive tracers by the activation by charged particles for the studying quantitative content of chemical elements and nanoparticles in biological samples and in the environment.
Material and methods: Theoretical analysis and test experiment were carried out to study the possibility of using various nuclear methods for detection of chemical elements and nanoparticles in biological and other samples, using the activation of different isotopes by a charged particles flux. The characteristics of the products and the various nuclear reactions, taken from the IAEA’s nuclear databases, have been considered. The irradiation of natural isotopes of titanium by fast neutron flux produces radioactive isotopes 46Sc and 47Sc (with half-life T1/2, respectively, equal to 83.8 and 3.35 days), by fast protons flux - 48V (T1/2 = 16 days) and by alpha-particles flux - 51Cr (T1/2 = 27.7 days). The flux of fast protons after interaction with the natural isotopes of platinum mixture generates radioactive isotope 195Au (T1/2 = 186 days), with the isotopes of iron - 56Co (T1/2 = 77.7 days), with the isotopes of manganese - 54Mn (T1/2 = 312 days), with europium isotopes - 151Gd (T1/2 = 124 days) and 153Gd (T1/2 = 241.6 days). We also consider the possibility of exposure to iron isotopes by fast deuterons flux with the formation of isotope 56Co. All radioactive isotopes are gamma-emitters and are suitable for the measuring on gamma-spectrometers. Particular attention is paid to the detection of nanoparticles of titanium dioxide, which takes one of the first places in the list of priority nanomaterials. For estimate the proportion of silver nanoparticles or another nanoparticles passing through the blood-brain barrier, evaluation of the content of iron in the blood can give a key information.
Results: The use of such methods in addition to the traditional neutron activation analysis expands the list of chemical elements, which can be successfully detected by the nuclear activation. This expansion includes such elements as titanium, iron, platinum, manganese, europium and some others.
Key words: nuclear-physical methods, radioactive tracer, charged particles, biokinetics, laboratory animals, the environment, nanoparticles
REFERENCES
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For citation: Demin VF, Antsifirova AA, Buzulukov YuP, Demin VA, Soloviev VY. FNuclear Physical Methods for the Detection of Chemical Elements in Biological and Other Samples Using Charged Particles Activation. Medical Radiology and Radiation Safety. 2015;60(2):60-5.
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