JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2018. Vol. 63. No. 2. P. 47-54
RADIATION THERAPY
DOI: 10.12737/article_5ac620f416a449.50054749
On Some Methodological Issues of Studying Cytogenetic Effects in Cancer Patients Treated with Neutron Therapy Using U-120 Cyclotron
V.A. Lisin
Tomsk Cancer Research Institute, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
V.A. Lisin - Dr. Sc. Tech., Prof.
Abstract
Purpose: To study dosimetric characteristics of neutron radiation field, to determine their role in the formation of the total cytogenetic effect in the patient’s body and to assess the cytogenetic dosimetry capabilities in improving the quality of NT.
Material and methods: A therapeutic beam with the average neutron energy of ~6.3 MeV was obtained from the V-120 cyclotron. The radiation field of the beam was investigated with the help of two ionization chambers with different sensitivity to neutrons. Chamber with high and low sensitivities were made of polyethylene and graphite, respectively. To exclude the uncertainty associated with the change in beam intensity in time, a dosimeter monitor operating in the integral mode was used.
Results: The dependence of the monitor factor on the irradiated area was measured. The distributions of the absorbed dose of neutrons and γ-radiation over the depth of the tissue-equivalent medium were found. The contribution of γ-radiation to the neutron dose was increased from ~10 % at the entry to the medium to ~30 % at a depth of 16 cm. Dose distributions of scattered neutron and γ-radiation in the plane of the end face of the forming device were obtained. The contribution of these radiations to the dose received by the patient’s body was estimated. This contribution was shown to be comparable with that from the therapeutic beam. The analysis of the influence of NT on the estimation of the frequency of chromosome aberrations in the blood of patients was carried out.
Conclusion: The frequency of chromosome aberrations in the blood of patients was determined by the whole-body dose, including dose due to scattered radiation. When using equal focal doses, the cytogenetic effect was found to be dependent on the area of the irradiated field and the depth of the tumor in the patient’s body. The differences in the RBE of neutrons and γ-radiation as well as the instability of the therapeutic neutron beam intensity create uncertainties that do not allow for the necessary control over the doses using the cytogenetic dosimetry. Therefore, cytogenetic dosimetry should be combined with an effective instrument dosimetry method.
The use of biodosimetry based on the assessment of the frequency of chromosome aberrations is promising for controlling the average whole-body dose, on which the overall radiation response of the body depends.
Key words: neutron therapy, cytogenetic effect, cyclotron U-120
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For citation: Lisin VА. On Some Methodological Issues of Studying Cytogenetic Effects in Cancer Patients Treated with Neutron Therapy Using U-120 Cyclotron. Medical Radiology and Radiation Safety. 2018;63(2):47-54. Russian. DOI: 10.12737/article_5ac620f416a449.50054749.
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