JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 2. P. 47-53
NUCLEAR MEDICINE
G.E. Kodina, V.N. Korsunsky, O.E. Klementyeva, A.O. Malysheva, M.V. Zhukova, N.A. Taratonenkova
Preliminary Biological Evaluation of 188Re-Sn Suspension as Promissing Radiopharmaceutical for Radiosynovectomy
Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENT
Purpose: To study the biological behavior of Rhenium-188 suspension as potential radiopharmaceutical for radiosynovectomy on experimental model of joint pathology.
Material and methods: The dynamic behavior of 188Re-Sn suspension was studied in rats with experimental acute aseptic synovitis of knee joint by direct radiometry. The biological behavior of radiopharmaceutical with SPECT/CT was carried out on rabbits with experimental acute aseptic synovitis of knee joint.
Results: We successfully synthesized 188Re-Sn suspension, which can be prepared in the special radiopharmaceutical departments and supplied in clinics according to their demand. This suspension is stable more than 3 days after its preparation. About 90 % of particles in the synthesized suspension were of lower than 9.3 μm. It was found that 188Re-Sn suspension was fixed in knee joint during 72 h post intraarticular injection in rats without redistribution. The SPECT/CT results confirmed the absence of radiopharmaceutical leakage from the injection site. Synthesized suspension could be prospective means for radiosynovectomy.
Key words: rhenium-188, suspension, acute synovitis, experimental model, radiosynovectomy