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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2018. Vol. 63. No. 3. P. 34-43
DIAGNOSTIC RADIOLOGY
DOI: 10.12737/article_5b179763e503b3.98376905
LEVELS OF TRACE ELEMENTS IN THE AFFECTED AREA OF BONE IN THE DIAGNOSIS OF OSTEOMYELITIS AND OSTEOGENIC SARCOMA
V.Ye. Zaichick
A.F. Tsyb Medical Radiological Research Center, Obninsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
V.Ye. Zaichick – Leading Researcher, Prof., Dr. Sc. Biol., PhD Tech., Fellow of the Royal Society of Chemistry, Chartered Chemist
Abstract
Purpose: Childhood bone cancer is often difficult to detect in its early stages. One of the most important differential diagnostics is between osteomyelitis (OM) and osteosarcoma (OS). To clarify the possible role of trace elements (TE) as osteosarcoma markers, a nondestructive neutron activation analysis were performed.
Material and methods: The Ag, Co, Cr, Fe, Hg, Rb, Sb, Se, and Zn contents were measured in three groups of samples: normal bone samples from 27 persons with intact bone, and also in samples, obtained from open biopsies or after operation of 10 patients with OM and 27 patients with OS. The difference in the results between TE contents in the three groups was evaluated by the parametric Student’s t-test and non-parametric Wilcoxon–Mann–Whitney U-test.
Results: In the OS tissue the mean mass fractions of Co, Fe, Se, and Zn are significantly higher (2.6, 2.6, 6.2, and 1.6 times, respectively) and the mean mass fraction of Rb is more than 2 times lower than in the inflamed bone. Different combinations of these TE mass fractions were checked as tumor markers.
Conclusion: It was shown that the level of SeZn mass fraction multiplication is the best tumor marker and can be recommended as an additional high informative test for differential diagnosis between OS and a normal or inflamed bone.
Key words: trace elements, human bone tissue, osteomyelitis, osteosarcoma, differential diagnostics, neutron activation analysis
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For citation: Zaichick V. Levels of Trace Elements in the Affected Area of Bone in the Diagnosis of Osteomyelitis and Osteogenic Sarcoma. Medical Radiology and Radiation Safety. 2018;63(3):34-43. DOI: 10.12737/article_5b179763e503b3.98376905
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