Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 3. P. 58–63

DOI: 10.12737/article_5cf3dfefe60b13.90120976

V.I. Chernov¹, E.A. Dudnikova¹, V.E. Goldberg¹, T.L. Kravchuk¹, A.V. Danilova¹, R.V. Zelchan¹, A.A. Medvedeva¹, I.G. Sinilkin1, O.D. Bragina¹, Yu.V. Belevich¹, E.S. Koroleva²

Single-Photon Emission Computerized Tomography in the Diagnosis and Monitoring of Lymphomas

1. Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ;
2. Siberian State Medical University, Tomsk, Russia

V.I. Chernov – Head of Dep., Dr. Sci. Med., Prof.;
E.A. Dudnikova – Junior Researcher;
V.E. Goldberg – Head of the Dep., Dr. Sci. Med., Prof.;
T.L. Kravchuk – Hematologist, PhD Med.;
A.V. Danilova – Hematologist;
R.V. Zelchan – Radiologist, PhD Med.;
A.A. Medvedeva – Senior Researcher, PhD Med.;
I.G. Sinilkin – Senior Researcher, PhD Med.;
O.D. Bragina – Junior Researcher, PhD Med.;
Yu.V. Belevich – Junior Researcher;
E.S. Koroleva – Associate Professor, PhD Med.

Abstract

Despite the high efficiency of the use of ¹⁸F-FDG PET in the diagnosis, staging, monitoring and prognosis of treatment of lymphomas, the use of this method in our country is limited due to the high cost and the insufficient number of PET-centers. In this regard, it seems relevant to conduct research aimed at using known and developing original radiopharmaceuticals for lymphoma imaging with single-photon emission computed tomography (SPECT). In this review, the main radiopharmaceuticals (⁶⁷Ga-citrate, ²⁰¹Tl, ¹⁹⁹Tl, ^99mTc-methoxy-isobutyl-isonitrile, ^99mTc-tetrofosmin, ¹¹¹In-octreotide), which are possible for SPECT lymphoma imaging are shown. Also mechanisms of their action, the possibility of their using for various morphological variants of lymphomas and localizations of the lesion are described. In addition, the results of the use of an innovative radiopharmaceutical based on glucose – ^99mTc-1-thio-D-glucose, which is promising for diagnostics, staging and monitoring of lymphoproliferative diseases, are presented.

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For citation: Chernov VI, Dudnikova EA, Goldberg VE, Kravchuk TL, Danilova AV, Zelchan RV, Medvedeva AA, Sinilkin IG, Bragina OD, Belevich YuV, Koroleva ES. Single-Photon Emission Computerized Tomography in the Diagnosis and Monitoring of Lymphomas. Medical Radiology and Radiation Safety. 2019;64(3):58-63. (Russian).

DOI: 10.12737/article_5cf3dfefe60b13.90120976

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