Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 1. P. 11-16

RADIATION BIOLOGY

V.Yu. Soloviev, A.E. Baranov

The Model Post-Radiation Kinetics of Cell Populations in Bone Marrow Syndrome

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Development of a mathematical model of recovery number of stem cell after acute total body irradiation.

Material and methods: The object of study is the data from a database of human acute radiation syndrome of A.I. Burnasyan Federal Medical Biophysical Center of FMBA on the post-radiation dynamics of the concentration of granulocytes in the peripheral blood of the victims of the Chernobyl accident in 1986.

Results: A model with mathematical description for the evaluation of post-radiation dynamics of stem cell pool and formed elements (granulocytes) in human peripheral blood is proposed. It is shown that the hypothetical idea of the trigger mechanism of the inclusion of several different modes of post-radiation recovery of stem cells pool and the existence of so-called critical level of the prohibition on differentiation does not contradict to the observed pattern of clinical data. A hypothesis is proposed about the possibility of external interference in the biological program of natural post-radiation recovery. It can lead to a less pronounced acute period of bone marrow syndrome in a dose range of 3-5 Gy. It may cause some reduction in agranulocytosis duration (at 2-4 days).

Conclusion: If the fundamental theoretical constructions are correct, we hope to find out some targeted therapies that can to some extent block the access to the differentiation of hematopoietic stem cells in a certain way and change the course of the clinical picture of bone marrow syndrome and, consequently, reduce some risk of death with severe and extremely severe bone marrow syndrome.

Key words: bone marrow syndrome, cell populations, granulocytes, model, gamma irradiation, dose

REFERENCES

1. Solov'ev V.Yu., Baranov A.E. Otsenka kriticheskogo urovnya «zapreta na differentsirovku» chislennosti stvolovykh krovetvornykh kletok cheloveka. 1989. Vol. 29. P. 835-838. (In Russ.).
2. Wichmann N.E., Loeffer M., Schmith S.A. Conception of haemopoietic regulation and its biomathematical realization. In: Blood Cells. SpringerVerlag. New York. 1988. P. 411-429.
3. Lajtha L.G. On the concept of the cell cycle. J. Cell Comp. Physiol. 1963. Vol. 62. No. 1. P. 143-145.
4. Lajtha L.G. Cytokinetics and regulation of progenitors cell. J. Cell Comp. Physiol. 1966. Vol. 67. No. 1. P. 133-148.
5. Lajtha L.G., Pozzi L.V., Schofield R., Fox M. Kinetic Properties of Haemopoietic Stem Cells. Cell Tiss. Kinet. 1969. No. 2. P. 39-49.
6. Lajtha L.G. Stem Cell Concepts. Differentiation. 1979. Vol. 14. P. 23-34.
7. Terskikh V.V. Periody pokoya v normal'nykh i malignizirovannykh kletochnykh sistemakh. V sb.: «Kletochnyi tsikl. Problemy regulyatsii». In Epifanovoi O.E. (ed.). Moscow: Nauka. 1973. P. 165-189. (In Russ.).
8. Konoplyannikov A.G. Radiobiologiya stvolovykh kletok. Moscow: Energoatomizdat. 1984. 120 p. (In Russ.).
9. Gruzdev G.P. Problema porazheniya krovetvornoi tkani pri ostroi luchevoi patologii. Moscow: Meditsina. 1968. 139 p. (In Russ.).
10. Gozenbuk V.L., Keirim-Markus I.B., Savinskii A.K., Chernov E.N. Dozovaya nagruzka na cheloveka v polyakh gamma-neitronnogo izlucheniya. Moscow: Atomizdat. 1978. 166 p. (In Russ.).
11. Gozenbuk V.L., Keirim-Markus I.B. Dozimetricheskie kriterii tyazhesti ostrogo oblucheniya cheloveka. Moscow: Energoatomizdat. 1988. 183 p.
12. Chervenick P.A., Boggs D.R. Patterns of proliferation and differentiation of hematopoetic stem cells after compartment depletion. Blood. 1971. Vol. 37. No. 5. P. 568-580.
13. Boggs S.S., Chervenick P.A., Boggs D.R. The effect of postirradiation bleeding or endotoxin on proliferation and differentiation of haematopoietic stem cells. Blood. 1972. Vol. 40. P. 375-379.
14. Boggs S.S., Boggs D.R. Relationship of stem cell poll size to onset differentiation. Radiat. Res. 1974. Vol. 59. P. 50-56.
15. Baranov A.E., Konchalovski M.V., Soloviev W.Ju., Guskova A.K. Use of blood cell count changes after radiation exposure in dose assessment and evaluation of bone marrow function. In: The Medical Basis for Radiation Accident Preparedness II. Clinical Experience and Followup since. In Ricks R.C., Fry S.A. (Eds.). 1979. P. 427-443.
16. Gruzdev G.P., Ivanova T.A., Gordeeva A.A., Shcherbova E.N. O funktsional'noi mozaichnosti kostnogo mozga («pul'siruyushchii klon»). gematol. 1980. No. 5. P. 36-39. (In Russ.).
17. Solov'ev V.Yu., Baranov A.E., Konchalovskii M.V., Chistopol'skii A.S. Prognozirovanie postradiatsionnoi dinamiki kontsentratsii neitrofilov v perifericheskoi krovi cheloveka pri neravnomernom obluchenii. Medical Radiology and Radiation Safety. 1997. Vol. 42. No. 3. P. 17-23. (In Russ.).
18. Solov'ev V.Yu., Baranov A.E., Khamidulin T.M. Baza dannykh po ostrym luchevym porazheniyam cheloveka. Soobshchenie 2. Prognozirovanie postradiatsionnoi dinamiki kontsentratsii neitrofilov perifericheskoi krovi cheloveka pri neravnomernom po telu avariinom obluchenii. Medical Radiology and Radiation Safety. 2011. Vol. 56. No. 4. P. 24-31. (In Russ.).
19. Semenkova I.V. Radiochuvstvitel'nost' mezenkhimal'nykh stvolovykh kletok i poluchaemykh iz nikh dlya tselei kletochnoi terapii kletok-predshestvennikov kardiomiotsitov. Obninsk. Avtoref. diss. kand. bilog. nauk. 2008. 16 p. (In Russ.).
20. Kilmen S.A. Rukovodstvo po radiatsionnoi gematologii. Moscow: Meditsina. 1974. P. 77-85. (In Russ.).
21. Pyatkin E.K., Baranov A.E. Biologicheskaya indikatsiya dozy s pomoshch'yu aberratsii khromosom i kolichestva kletok v perifericheskoi krovi. Itogi nauki i tekhniki VINITI AN SSSR. Ser. «Radiatsionnaya biologiya». 1980. Vol. 3. P. 103-179. (In Russ.).
22. Konchalovskii M.V., Baranov A.E., Solov'ev V.Yu. Dozovye krivye neitrofilov i limfotsitov pri obshchem otnositel'no ravnomernom gamma-obluchenii cheloveka (po materialam avarii na ChAES). Medical Radiology and Radiation Safety. 1991. Vol. 36. No. 1. P. 29-33. (In Russ.).
23. Solov'ev V.Yu., Baranov A.E., Khamidulin T.M., Zinov'eva N.V. Baza dannykh po ostrym luchevym porazheniyam cheloveka. Soobshchenie 3. Osobennosti prognozirovaniya postradiatsionnoi dinamiki kontsentratsii neitrofilov v perifericheskoi krovi pri kostnomozgovom sindrome, otyagoshchennom luchevymi ozhogami, a takzhe pri neravnomernom obluchenii.Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 6. P. 30-35. (In Russ.).

For citation: Soloviev VYu, Baranov AE. The Model Post-Radiation Kinetics of Cell Populations in Bone Marrow Syndrome. Medical Radiology and Radiation Safety. 2016;61(1):11-6. Russian.

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