Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 1. P. 73-77

MEDICAL PRACTICE ISSUE

S.B. Alieva1, A.V. Nazarenko1, I.A. Zaderenko2, L.I. Lebedeva1, R.R. Kaledin1, E.L. Dronova1, I.A. Gladilina1

Late Radiation Damage after Reirradiation for Recurrent Nasopharyngeal Carcinoma

1. N.N. Blokhin Russian Cancer Research Center of RAMS, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Moscow State Medical and Dental University, Moscow, Russia

ABSTRACT

Introduction: The recurrence rate of nasopharyngeal cancer is 8-58 %. The main treatment is to conduct a repeated course of radiation therapy which is associated with a high risk of severe complications.

Case report: This article presents a case of reiiradiation of recurrence squamous cell carcinoma of the nasopharynx.

Discussion and conclusion: The incidence of severe post-irradiation damage during reirradiation of recurrence nasopharyngeal cancer depends on the received dose and the method of treatment. Application of conformal radiotherapy reduces posttherapeutic complications in 2.5 times.

Key words: nasopharyngeal cancer, recurrence, radiation therapy, late postradiation complications

REFERENCES

  1. Bardychev M.S. Mestnye luchevye povrezhdeniya i ikh klassifikatsiya. V sb.: «Diagnostika i lechenie pozdnikh mestnykh luchevykh povrezhdenii». Obninsk. 1988. P. 3-11.
  2. Aliev B.M., Chuprik-Malinovskaya T.P., Gladilina I.A., Khromyshev A.E. Analiz kharaktera neudach pri lechenii raka nosoglotki i rezul'taty ikh lecheniya. Vestnik RONTs im. N.N. Blokhina RAMN. 1994. No. 3. P. 25-28.
  3. Lee A.W., Law S.C., Foo W. et al. Retrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: survival after local recurrence. Int. J. Radiat. Oncol. Phys. 1993. Vol. 26. No. 5. P. 773-782.
  4. Wang C.C. Re-irradiation of recurrent nasopharyngeal carcinoma: treatment techniques and results. Int. J. Radiat. Oncol. Biol. Phys. 1987. Vol. 13. No. 7. P. 953-956.
  5. Yan J.H., Hu Y.H., Gu X.Z. Radiation therapy of recurrent nasopharyngeal carcinoma: report on 219 patients. Acta. Radiol. Onc 1983. Vol. 22. No. 1. P. 23-28.
  6. Pryzant R.M., Wendt C.D., Delclos L., Peters L.J. Retreatment of nasopharyngeal carcinoma in 53 patients. Int. J. Radiat. Biol. Phys. 1992. Vol. 22. No. 5. P. 941-947.
  7. Teo P.M., Kwan W.H., Chan A.T. et al. How successful is high-dose (> or = 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma? Int. J. Radiat. Biol. Phys. 1998. Vol. 40. No. 4. P. 897-913.
  8. Chang J.T., See L.C., Liao C.T. et al. Locally recurrent nasopharyngeal carcinoma. Radiother. Oncol. 2000. Vol. 54. No. 2. P. 135-142.
  9. Lee A.W., Foo W., Law S.C. et al. Reirradiation for recurrent nasopharyngeal carcinoma: factors affecting the therapeutic ratio and ways for improvement. Int. J. Radiat. Biol. Phys. 1997. Vol. 38. No. 1. P. 43-52.
  10. Chua D.T., Sham J.S., Leung L.H., Au G.K. Reirradiation of nasopharyngeal carcinoma with intensitymodulated radiotherapy. Radiother. Oncol. 2005. Vol. 77. No. 3. P. 290-294.

For citation: Alieva SB, Nazarenko AV, Zaderenko IA, Lebedeva LI, Kaledin RR, Dronova EL, Gladilina IA. Late Radiation Damage after Reirradiation for Recurrent Nasopharyngeal Carcinoma. Medical Radiology and Radiation Safety. 2016;61(1):73-7. Russian.

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