Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 5. P. 37-54

NUCLEAR MEDICINE

I.P. Aslanidis¹, D.M. Pursanova¹, O.V. Mukhortova¹, T.A. Katunina¹, O.B. Karyakin², V.A. Biryukov²

The Role of ¹¹C-/¹⁸F-Choline PET/CT in the Detection of Recurrent Prostate Cancer in Patients with Biochemical Recurrence

1. A.N. Bakoulev Center for Cardiovascular Surgery of RAMS, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Medical Radiation Research Center, Obninsk, Russia

Abstract

1. Introduction
2. Diagnostic Evaluation of Prostate Cancer Relapse

      2.1. PSA Serum Level and PSA Kinetics in Prostate Cancer Patients With Biochemical Relapse

      2.2. Transrectal Ultrasonography

      2.3. Bone Scintigraphy

      2.4. Computer Tomography

      2.5. Magnetic-resonance Tomography

3. PET/CT with non-choline radiopharmaceuticals in Prostate Cancer Patients

      3.1. ¹⁸F-FDG

      3.2. ¹¹C-acetate

      3.3. ¹¹C-methionine

      3.4. ¹⁸F-fluorodihydrotestosterone (¹⁸F-FDHT)

      3.5. ¹⁸F-fluorothymidine (¹⁸FLT)

      3.6. ¹⁸F-fluoromethylarabinofuranosyluracil FMAU)

      3.7. ⁶⁸Gallium-labelled Prostate-Spesific Membrane Antigen (⁶⁸Ga-PSMA)

4. ¹¹C-/¹⁸F-Choline PET/CT

      4.1. ¹¹C-/¹⁸F-Choline PET/CT in Primary Diagnosis of Prostate Cancer

      4.2. ¹¹C-/¹⁸F-Choline PET/CT in Staging of Prostate Cancer

      4.3. ¹¹C-/¹⁸F-Choline PET/CT in Early Relapse of Prostate Cancer

      4.4. ¹¹C-/¹⁸F-Choline PET/CT for Detection of Bone Metastases in Prostate Cancer Patients

5. Conclusion.

Key words: prostate cancer, PET/CT, C-Choline, ¹⁸F-Choline, PSA, PSA kinetics