Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 6. P. 43-48


S.I. Tkachev, P.V. Bulychkin, A.V. Berdnik, S.V. Medvedev, A.V. Zavistovsky, R.A. Gutnik, I.P. Yghunovich, U.B. Bykova, I.N. Kurganova, G.I. Hagverdieva

Hypofractionated Salvage Radiation Therapy for Patients with Recurrence Prostate Cancer after Radical Prostatectomy

N.N.Blokhin Russian Cancer Research Center of RAMS. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: Creation, implementation and clinical evaluation of hypofractionation salvage radiation therapy (SRT) in patients with recurrent prostate cancer after radical prostatectomy.

Material and methods: There has been created a new scheme of hypofractionation SRT using simultaneous integrated boost for patients with biochemical and clinical recurrence of prostate cancer after radical prostatectomy. There have been evaluated and compared 40 patients who were treated by two methods of radiation therapy (classical fractionation and hypofractionation).

Results: the new scheme of hypofractionation SRT reduces equivalent uniform dose of the rectum and bladder compare classical fractionation SRT. The early biochemical response rates were consistent with expectations from conventional fractionation. Additional follow-up is required to better document the biochemical control. But these results suggest that hypofractionation is a well-tolerated approach for SRT.

Key words: prostate cancer, recurrence, salvage radiation therapy, hypofractionation, simultaneous integrated boost