Medical Radiology and Radiation Safety. 2021. Vol. 66. № 5. P. 59–65
Potential Possibilities of Nuclear Medicine Methods in Diagnostics Age Changes of the Cardiovascular System.
M.V. Vorontsova1, A.A. Obrezan 2, A.G. Obrezan 1,2
1JSC NOMECO, Saint-Petersburg, Russia
2Saint-Petersburg State University, Saint-Petersburg, Russia
Contact person: Andrei Andreevich Obrezan: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENT
• Summary
• Introduction
• Structural and functional changes in the cardiovascular system during natural aging
• Methods for the study of age-related changes in the myocardium and large vessels used in clinical practice today
• The potential of nuclear medicine methods in the diagnosis of age-related changes in the cardiovascular system
• Conclusion
Key words: nuclear cardiology, radionuclide diagnostics, age changes, cardiovascular system, positron emission tomography
For citation: Vorontsova MV, Obrezan AA, Obrezan AG. Potential Possibilities of Nuclear Medicine Methods in Diagnostics Age Changes of the Cardiovascular System. Medical Radiology and Radiation Safety. 2021;66(5):59-65.
DOI: 10.12737/1024-6177-2021-66-5-59-65
References
1 Moskalev A.A., Shaposhnikov M.V., Soloviev I.A. Studying the geroprotective effects of inhibitors suppressing aging-associated signaling cascades in model organisms // Medical news of North Caucasis. 2017. 12. P. 342-347. DOI: 10.14300/mnnc.2017.12090. (in Russian)
2 Laurent S, Boutouyrie P, Guimarães Cunha P, Lacolley P, Nilsson PM. Concept of Extremes in Vascular Aging From Early Vascular Aging to Supernormal Vascular Aging // Hypertension. 2019. 74. P. 218-228. DOI: 10.1161/HYPERTENSIONAHA.119.12655.
3 Lishmanov Yu.B., Zavadovsky K.V., Efimova N.Yu., Krivonogov N.G., Efimova I.Yu., Vesnina Zh.V., Sazonova S.I., Saushkina Yu.V., Saushkin V.V., Ilyushenkova Yu.N., Gulya M.O., Peshkin Ya.A., Mochula A.V. PROSPECTS OF NUCLEAR MEDICINE FOR THE DIAGNOSIS OF CARDIOVASCULAR DISEASES // Siberian medical journal. 2015. 30(2). P. 21-29. https://doi.org/10.29001/2073-8552-2015-30-2-21-29. (in Russian)
4 Heron M. Deaths: leading causes for 2011 // Natl Vital Stat Rep. 2015. 64. P. 1-96.
5 Plokhova E.V., Akasheva D.U., Tkacheva O.N., Strazhesko I.D., Dudinskaya E.N., Kruglikova A.S., Pykhtina V.S., Agaltsov M.V., Sharashkina N.V., Brailova N.V., Skvortsov D.A., Boytsov S.A. Age-related remodeling of the left ventricular myocardium: is there a link with cellular aging? // Cardiovascular Therapy and Prevention, 2015. 14(2). P. 52–57. http://dx.doi.org/10.15829/1728-8800-2015-2-52-57. (in Russian)
6 Cuspidi C, Facchetti R, Sala C et al. Normal values of left-ventricular mass: echocardiographic findings from the PAMELA study // J Hypertens. 2012. 30(5). P. 997-1003. DOI: 10.1097/HJH.0b013e328352ac39.
7 Leibowitz D, Gilon D. Echocardiography and the Aging Heart // Current Cardiovascular Imaging Reports. 2012. 5(6). P. 501-506.
8 Shock NW, Greulich RC, Andres RA, et al. Normal human aging: the Baltimore Longitudinal Study of Aging. Bethesda, MD: NIH Pub No 84-2450; 1984.
9 Mendes AB, Ferro M, Rodrigues B, et al. Quantification of left ventricular myocardial collagen system in children, young adults, and the elderly // Medicina (B Aires). 2012. 72(3). P. 216-220. PMID: 22763158.
10 Blagova O.V., Nedostup A.V., Sedov V.P., Kogan E.A., Pasha S.P., Gagarina N.V., Alieva I.N., Sedov A.V., Tsaregorodtsev D.A., Kulikova V.A., Shepeleva N.E., Sarkisova N.D. Clinical Masks of Amyloidosis With the Heart Involvement: Modern Diagnostic Issues // Russian Journal of Cardiology. 2017. (2). P. 68-79. https: //doi.org/10.15829/1560-4071-2017-2-68-79. (in Russian.)
11 Damy T, Mohty D, Deux JF, et al. Senile systemic amyloidosis: Definition, diagnosis, why thinking about? // Presse Med. 2013. 42(6 Pt 1). P. 1003-14. doi: 10.1016/j.lpm.2013.03.004.
12 Groznova O.S., Miklashevich I.M., Voinova V.Yu., Shkolnikova M.A., Tkacheva O.N., Dudinskaya E.N., Kovalev I.A. Biomarkers of early cardiovascular aging // Ros Vestn Perinatol i Pediatr. 2019. 64:(4). P. 11-18. DOI: 10.21508/1027-4065-2019-64-4-11-18. (in Russian)
13 Strazhesko I.D., Akasheva D.U., Dudinskaya E.N., Tkacheva O.N. Vascular ageing: main symptoms and mechanisms // Cardiovascular Therapy and Prevention. 2012. 11(4). P. 93-100. https://doi.org/10.15829/1728-8800-2012-4-93-100. (in Russian)
14 Cunha P.G., Olsen M.H. Chapter 24. Vascular Aging and Cardiovascular Disease. In: Nilsson P.M., Olsen M.H., Laurent S., eds. Early Vascular Aging (EVA). New Directions in Cardiovascular Protection // Academic Press. 2015. P. 261-71. DOI:10.1016/B978-0-12-801387-8.00025-9.
15 Tesauro M, Mauriello A, Rovella V et al. Arterial ageing: from endothelial dysfunction to vascular calcification // J. Intern. Med. 2017. 281(5). P. 471–482. doi: 10.1111/joim.12605
16 Villa F., Carrizzo A., Spinelli C.C., Ferrario A., Malovini A., Maciąg A. et al. Genetic Analysis Reveals a Longevity-Asso- ciated Protein Modulating Endothelial Function and Angio- genesis // Circ Res. 2015. 117(4). P. 333–345. DOI: 10.1161/CIR- CRESAHA.117.305875
17 Sohn E.H., Flamme-Wiese M.J., Whitmore S.S., Wang K., Tucker B.A., Mullins R.F. Loss of CD34 expression in aging human choriocapillaris endothelial cells // PLoS One. 2014. 9(1). e86538. DOI: 10.1371/journal.pone.0086538.
18 Anthony J. Donato, Daniel R. Machin, Lisa A. Lesniewski. Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease // Circ Res. 2018. 123. P. 825-848. DOI: 10.1161/CIRCRESAHA.118.312563.
19 Laurent S., Boutouyrie P. Arterial Stiffness and Hypertension in the Elderly // Front. Cardiovasc. Med. 2020. 7:544302. doi: 10.3389/fcvm.2020.544302.
20 Ansheles A.A., Sergienko I.V., Sergienko V.B. Current State and Future Technologies of Nuclear Imaging in Cardiology // Kardiologiia. 2018. 58(6). P. 61-69. DOI: 10.18087/cardio.2018.6.10134. (in Russian)
21 Cheng S, Xanthakis V, Sullivan LM, et al. Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course: Longitudinal Observations from the Framingham Heart Study // Circulation. 2010. 122(6). P. 570–578. doi: 10.1161/CIRCULATIONAHA.110.937821.
22 Pierdomenico SD, Di Nicola M, Pierdomenico AM, et al. Cardiovascular risk in subjects with left ventricular concentric remodeling at baseline examination: a meta-analysis // J. Hum. Hypertens. 2011. 25(10). P. 585-591. DOI: 10.1038/jhh.2011.24.
23 Carrick-Ranson G, Hastings JL, Bhella PS, et al. Effect of healthy aging on left ventricular relaxation and diastolic suction // Am. J. Physiol. Heart. Circ. Physiol. 2012. 303(3). P. 15-22. DOI: 10.1152/ajpheart.00142.2012.
24 John Eng, Robyn L. McClelland, Antoinette S. Gomes, et al. Adverse left Ventricular remodeling and age assessed with cardiac Mr imaging: The Multi-Ethnic Study of Atherosclerosis // Radiology. 2016. 278(3). P. 714-722. https://doi.org/10.1148/radiol.2015150982.
25 Reference Values for Arterial Stiffness’ Collaboration. Determinants of pulse wave velocity in healthy pe- ople and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’ // Eur Heart J. 2010. 31(19). P. 2338–2350.
26 M. AlGhatrif, J.B. Strait, C.H. Morrell et al. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging // Hypertension. 2013. 62(5). P. 934-941. DOI: 10.1161/HYPERTENSIONAHA.113.01445.
27 Said MA, Eppinga RN, Lipsic E et al. Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality // J Am Heart Assoc. 2018. 7(2). URL: https://doi.org/10.1161 /JAHA.117.007621.
28 Lassale C, David Batty G, Steptoe A, Cadar D, Akbaraly TN, Kivimäki M, Zaninotto P. Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging // J Gerontol A Biol Sci Med Sci. 2019. 74(2). P. 195–203. https://doi.org/10.1093/gerona/gly028.
29 Ling LH., Kistler PM., EllimsAH., Iles LM., Lee G., Hughes GL., Kalman JM., Kaye DM., Taylor AJ. Diffuse ventricular fibrosis in atrial fibrillation: noninvasive evaluation and relationships with aging and systolic dysfunction // J. Am. Coll. Cardiol. 2012. 60. P. 2402–2408. DOI:10.1016/j.jacc.2012.07.065.
30 Bekmurzinova F.K., Ospanov O.B., Akilzhanova A.R., Kozhamkulov U.A., Rakhimova S.E. The evaluation of chromosome telomere length change as a criterion of life expectancy in bariatric practice // Obesity and metabolism. 2020. 17(2). P. 125-129. https://doi.org/10.14341 /omet1033. (in Russian)
31 Bressler J, Franceschini N, Demerath EW et al. Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study // BMC Med Genet. 2015. 16. P. 52. DOI: 10.1186/s12881-015-0194-x.
32 National guide to radionuclide diagnostics 2010. - Vol. 2. - 418 p. / ed. by Yu. B. Lishmanov, V. I. Chernov. - In 2 volumes-Tomsk : ISBN 980-5-93629-427-3.
33 A. Freund. Untangling Aging Using Dynamic, Organism-Level Phenotypic Networks // Cell Systems. 2019. 86. P. 172-181. https://doi.org /10.1016/j.cels.2019.02.005.
34 Sergienko V.B., Tereshchenko S.N., Ansheles A.A., Zhirov I.V., Safiullina A.A. Nuclear Imaging in the Diagnosis of Cardiac Amyloidosis // Rational Pharmacotherapy in Cardiology. 2018. 14(1). P. 94-100. DOI: 10.20996/1819-6446-2018-14-1-94-100. (in Russian)
35 Sergienko V.B., Ansheles A.A. Radionuclide diagnosis in cardiology. In: Chazov E.I., ed. Manual of cardiology. Volume 1. Moscow: Praktika. 2014. P. 571-612. (in Russian.)
36 Moghbel M., Al-Zaghal A., Werner T.J., Constantines- cu C.M., Høilund-Carlsen P.F., Alavi A. The role of pet in evaluating atherosclerosis: a critical review // Semin. Nucl. Med. 2018. 48(6). P. 488–497. DOI: 10.1053/j.sem- nuclmed.2018.07.001.
37 Karpova N.Yu., Rashid M.A., Kazakova T.V. et al. Calcific aortic stenosis: known facts and promising studies // The Clinician. 2020. 14(1–2). P. 34–41. DOI: 10.17650/1818-8338-2020-14-1-2-34-41. (in Russian.)
38 Ansheles A. A., Shigoleva Ya. V., Sergienko I. V., Tereshchenko S. N. SPECT myocardial perfusion and sympathetic innervation in patients with hypertrophic cardiomyopathy // Kardiologicheskij Vestnik. 2016. 11(1). P. 24-33. (in Russian.)
39 Chapman J., Fielder E., Passos J.F. Mitochon- drial dysfunction and cell senescence: deciphering a complex relationship // FEBS Lett. 2019. 593. P. 1566–1579. DOI: 10.1002/1873-3468.13498.
40 Korolchuk V.I., Miwa S., Carroll B., von Zglinicki T. Mitochondria in cell senescence: is mitophagy the weakest link? // EBio Medicine. 2017. 21. P. 7–13. DOI: 10.1016/j.ebiom.2017.03.020.
41 Safee ZM, Baark F, Waters ECT, et al. Detection of anthracycline induced cardiotoxicity using perfusioncorrected (99m)Tc sestamibi SPECT // Sci Rep. 2019. 9(1). P. 216. doi:10.1038/s41598018367215.
42 Ansheles A.A., Sergienko I.V., Prus Yu.A., Sergienko V.B. Nuclear imaging of chemotherapyinduced cardiotoxicity // Cardiovascular Therapy and Prevention. 2021. 20(2). P. 25-37. doi:10.15829/1728880020212537. (in Russian.)
43 Ferrucci L., Gonzalez-Freire M., Fabbri E., Simon- sick E., Tanaka T., Moore Z., Salimi S., Sierra F., de Cabo R. Measuring biological aging in humans: a quest // Aging Cell. 2020. 19. e13080. DOI: 10.1111/acel.13080.
44 Nilsson M.I., Tarnopolsky M.A. Mitochondria and aging-the role of exercise as a countermeasure // Biology. 2019. 8. P. 40. DOI: 10.3390/biology8020040.
45 Moro L. Mitochondrial dysfunction in aging and cancer // J. Clin. Med. 2019. 8. 1983. DOI: 10.3390/jcm8111983.
46 Sergienko VB. Modern possibilities of radionuclide molecular imaging of atherosclerosis // Atherosclerosis and Dyslipidemia. 2016. 4(25). P. 5-13. (in Russian)
47 Proshkina E.N., Solovev I.A., Shaposhnikov M.V., Moskalev A.A. Key molecular mechanisms of aging, biomarkers and potential interventions // Molecular biology. 2020. 54(6). P. 883–921. DOI: 10.31857/S002689 8420060099. (in Russian)
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Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors
Article received: 23.12.2020.
Accepted for publication: 20.01.2021.