Medical Radiology and Radiation Safety. 2021. Vol. 66. № 6. P. 34–38
Influence of Drinking Water Quality on the Current of Acute Radiation Disease in Mice
Bychkova T.M.1,2, Andrianova I.E.1, Nikitenko O.V.1,2, Stavrakova N.M.1, Parfenova I.M.1, Karaulova T.A.1, Gordeev A.V.1, Ivanov A.A.1,2,3
1A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
2RFSSC Institute of Biomedical Problems, Moscow, Russia
3Joint Institute for Nuclear Research, Dubna, Russia
Contact person: Taisia Mikhailovna Bychkova: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Assessing the role of various factors in the formation of radioresistance is an important branch of radiobiology. The quality of drinking water, as it turned out, can significantly affect radioresistance. Against the background of studying the antiradiation properties of various types of water, differing in mineral and isotopic composition, the problem of the influence of tap water on the course of radiation injury remained underestimated. This circumstance determined the purpose of the work: to evaluate the modifying effect of tap water on the course of acute radiation sickness after X-ray irradiation of mice at an average lethal dose.
Material and methods: Female ICR (CD-1) mice were irradiated with an average lethal dose once – 6.5 Gy of X-ray irradiation. After irradiation, half of the mice received tap water as drinking water, and the other half received artificially mineralized drinking water.
Results: Keeping animals on tap water significantly reduced the survival rate of mice both with a single dose (log-rank test p=0.02, χ2=5.38) compared with animals receiving artificially mineralized distilled water. In addition, in the group of mice that received tap water, an increase in the rate of death of mice and a lower preservation of the group mass of animals during the development of acute radiation injury was noted.
Conclusion: Tap water, used as drinking water, increases the damaging effect of radiation when X-rays are irradiated in mice.
Key words: tap water, artificially mineralized distilled water, X-ray irradiation, survival rate, mortality rate, mice, model
For citation: Bychkova TM, Andrianova IE, Nikitenko OV, Stavrakova NM, Parfenova IM, Karaulova TA, Gordeev AV, Ivanov AA. Influence of Drinking Water Quality on the Current of Acute Radiation Disease in Mice. Medical Radiology and Radiation Safety. 2021;66(6):34–38.
DOI: 10.12737/1024-6177-2021-66-6-34-38
References
1. Yagunov A.S., Reeves G.I., Tokalov S.V., Chukhlovin A.B., Afanassiev B.V. Animal Studies of Residual Hematopoietic and Immune System Injury from Low Dose/Low Dose Rate Radiation and Heavy Metals. Bethesda, MD, Armed Forces Radiobiology Research Institute, 1998. (AFFRI). DOI:10.13140/2.1.3584.0007.
2. Carpenter D.O., Bushkin-Bedient S. Exposure to Chemicals and Radiation During Childhood and Risk for Cancer Later in Life. J. Adolesc Health. 2013;52;5:21-29. doi:10.1016/j.jadohealth .2013.01.027.
3. Vacek A., Sikulová J., Bartonícková A. Radiation Resistance in Mice Increased Following Chronic Application of Li2CO3. Acta Radiol Oncol. 1982;21;5:325-330. doi:10.3109/0284186820 9134023.
4. Chlorinated Drinking-Water; Chlorination by-Products; Some other Halogenated Compounds; Cobalt and Cobalt Compounds. International Agency for Research on Cancer (IARC) Working Group, Lyon, 12-19 June 1990. IARC Monogr Eval Carcinog Risks Hum. 1991;52:45-399.
5. National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of Chlorinated Water (CAS Nos. 7782-50-5 and 7681-52-9) and Chloraminated Water (CAS No. 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). Natl Toxicol Program Tech Rep Ser. 1992;392:1-466.
6. Sanitary and Epidemiological Rules and Regulations SanPiN 2.1.4.1074-01 Drinking Water. Hygienic Requirements for Water Quality of Centralized Drinking Water Supply Systems. Quality Control. Hygienic Requirements for Ensuring the Safety of Hot Water Supply Systems (In Russian).
7. Kaplan E.L., Meier P. Non-Parametric Estimation from Incomplete Observations. J. Am. Stat. Assoc. 1958;53;282:457–481.
8. Sacher G.A. On the Statistical Nature of Mortality, with Especial Reference to Chronic Radiation Mortality. Radiology. 1956;67;2:250-258. doi: 10.1148/67.2.250.
9. WHO Library Cataloging in publication data Guidelines for drinking water quality. WHO, 2011. P. 584.
10. Rakhmanin Yu.A. Biophysics of Water: Quantum Nonlocality in Water Treatment Technologies, the Regulatory Role of Associated Water in Cellular Metabolism, Regulation of the Bioenergetic Activity of Drinking Water. Eds. Rakhmanin Yu.A., Stekhin A.A., Yakovleva G.V. Moscow, URSS Publ., 2016. 346 p. (In Russian).
11. Ivanov A.A., Andrianova I.Ye., Mal'tsev V.N., Shalnova G.A., Stavrakova N.M., Bulynina T.M., Dorozhkina O.V., Karaulova T.A.,Gordeev A.V., Bushmanov A.Yu. The Impact of Drinking Water of Various Quality on Intact and Irradiated Mice. Gigiena i Sanitariya = Hygiene and Sanitation. 2017;9:854-860. DOI:10.18821/0016-9900-2017-96-9-854-860 (In Russian).
12. Laissue J.A., Altermatt H.J., Bally E., Gebbers J.O. Protection of Mice from Whole Body Gamma Irradiation by Deuteration of Drinking Water: Hematologic Findings. Exp. Hematol. 1987;15;2:177-180.
13. Ivanov A.A., Ushakov I.B., Kulikova E.I., Kryuchkova D.M., Severyukhin Yu.S., Vorozhtsova S.V., Abrosimova A.N., Gayevskiy V.A., Sinyak Yu.Ye., Grigoryev A.I. Light-Isotope Water as a Therapeutic Agent for Acute Radiation Disease. Aerospace and Environmental Medicine. 2013;47;5:40–44 (In Russian).
14. Abrosimova A.N., Rakov D.V., Sinyak Yu.E. The "Light" Water Effect on Lenticular Opacity Development in Mice after Repeated Low Dose Gamma-Irradiation. Aerospace and Environmental Medicine. 2009;43;2:29-32 (In Russian).
15. Kulikova E.I., Kryuchkova D.M., Severyukhin Yu.S., Gaevsky V.N., Ivanov A.A. Radiomodifying Properties of Deuterium-Depleted Water with Poor Content of Heavier Isotopes of Oxygen. Aerospace and Environmental Medicine. 2012;46;6:45-50 (In Russian).
16. Kryuchkova D.M., Andrianova I.E., Kovalenko M.A., Vorozhtsova S.V., Gaevsky V.N., Ivanov A.A. Effect of A Mineral Organic Complex on Mice Radioresistance. Aerospace and Environmental Medicine. 2013;47;5:37-40 (In Russian).
17. Cantor K.P., Hoover R., Hartge P., et al. Bladder Cancer, Drinking Water Source, and Tap Water Consumption: a Case-Control Study. J. Natl. Cancer Inst. 1987;79;6:269-1279.
18. Ishidate M.Jr., Sofuni T., Yoshikawa K., Hayashi M., et al. Primary Mutagenicity Screening of Food Additives Currently Used in Japan. Food and Chemical Toxicology 1984;22;8:623-636. doi.org/10.1016/0278-6915(84)90271-0.
19. Eltahawy N.A., Sarhan O.M., Hammad A.S., et al. Effects of Combined Exposure to Aluminum Chloride and γ-Radiation on Histological and Ultrastructure of Intestinal Paneth Cells. Radiat. Res. Appl. Sci. 2016;9:400-408. doi.org/10.1016/j.jrras.2016.05.007.
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 10.08.2021
Accepted for publication: 21.09.2021