Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
Study of the Functional Relationship of the Brain in Patients
with Asymptomic Carotidal Senosis
Pospelova M.L., Efimtsev A.Y., Lepekhina A.S., Trufanov G.E., Alekseeva T.M., Ivanova N.E., Efimova M.Y., Voronin A.S.,
Makhanova A.M., Mikhalicheva A.A.
V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia
Contact person: A.S. Lepekhina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To explore functional connectivity in patients with asymptomatic internal carotid arteries stenosis of more than 60% when using hirudotherapy.
Materials and methods: The analysis of the results of the examination of 15 patients aged 60 to 82 years with asymptomatic stenosis of the carotid arteries in the range of 60‒75 % was carried out. The patients underwent a course of hirudotherapy, consisting of 10 sessions. All patients underwent structural and functional magnetic resonance imaging with analysis of statistical data at rest, complaints and neurological status were assessed ‒ before and after the course of hirudotherapy.
Results: When using a course of hirudotherapy in patients with asymptomatic internal carotid arteries tenosis, when analyzing the neurological status and complaints, a significant improvement in well-being was noted. During functional magnetic resonance imaging, differences in functional connectivity between the medial prefrontal cortex and other areas of the brain were determined. Activation was noted in the main structures of the network of managerial control and identification of significance. Connectivity between the leading regions of the brain increased, which is a sign of improved brain activity.
Conclusion: Connectivity research can be used to study the functioning of brain networks and to determine the effectiveness of therapy. The course of hirudotherapy significantly changed the functional connectivity of the brain regions, the changes correlated with a decrease in the number of complaints. This work is a pilot and will be continued for the further development of treatment-and-prophylactic strategies with the inclusion of hirudotherapy in patients with a high risk of vascular accidents in a treatment.
Keywords: asymptomatic carotid stenosis, hirudotherapy, fMRI, connectome
For citation: Pospelova ML, Efimtsev AY, Lepekhina AS, Trufanov GE, Alekseeva TM, Ivanova NE, Efimova MY, Voronin AS, Makhanova AM, Mikhalicheva AA. Study of the functional relationship of the brain in patients with asymptomic carotidal senosis. Medical Radiology and Radiation Safety. 2022;67(2):59-63. (In Russian) doi: 10.33266/1024-6177-2022-67-2-59-63
References
1.Seung S. Konnektom = Connectome. Moscow, Binom. Laboratoriya Znaniy Publ., 2014. P. 440. ISBN 978-5-9963-1685-4
(In Russ.).
2.Fornito A., Bullmore E.T. Connectomics: a New Paradigm for Understanding Brain Disease. European Neuropsychopharmacology. 2015;25;5:733-748. DOI:10.1016/j.euroneuro.2014.02.011.
3.Fornito A., Zalesky A., Breakspear M. The Connectomics of Brain Disorders. Nature Reviews Neuroscience. 2015;16;3:159-172. DOI:10.1038/nrn3901.
4.Porshinsky B.S., Saha S., Grossman M.D., et al. Clinical Uses of the Medicinal Leech: a Practical Review. Journal of Postgraduate Medicine. 2011;57;1:65-71. DOI: 10.4103/0022-3859.74297.
5.Pospelova M.L., Barnaulov O.D. Doppler Study of the Effectiveness of Hirudotherapy in Patients with Chronic Vertebrobasilar Insufficiency and Stage 1 Discirculatory Encephalopathy. Regionarnoye Krovoobrashcheniye i Mikrotsirkulyatsiya = Regional Blood Circulation and Microcirculation. 2010;2;34:40-43. DOI:10.24884/1682-6655-2010-9-2-40-43 (In Russ.).
6.Semikova T.S., Semikova M.V. Girudoterapiya v Oftalmologicheskoy Praktike = Hirudotherapy in Ophthalmic Practice. Novyye Tekhnologii Mikrokhirurgii Glaza: Materialy XII Nauchno-Prakticheskoy Konferentsii = New Technologies of Eye Microsurgery: Materials of the XII Scientific-Practical Conference. Orenburg, IPK “Gazprompechat” Publ., 2001.
P. 65–66. ISBN 5-94397-017-7 (In Russ.).
7.Dobrynina L.A., Gadzhiyeva Z.SH., Morozova S.N., et al. Executive Functions: Fmri of Healthy Volunteers During Stroop Test and the Serial Count Test. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2018;3:64-71. DOI:10.17116/jnevro201811811164 (In Russ.).
8.Pospelova M.L., Zaytsev D.Ye., Lepekhina A.S., YEfimtsev A.Yu., Alekseyeva T.M., Trufanov G.Ye. Cognitive Lesion in Patients with Asymptomic Carotid Stenoses more than 70% – Indication for Surgical Treatment? Sovremennyye Problemy Nauki i Obrazovaniya = Modern Problems of Science and Education. 2019;5. URL: http://www.science-education.ru/ru/article/view?id=29046 (Date of Access: 06/01/2021) (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.