Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4

To the Question About Pharmacological Protection During Irradiation In Non-infecting Doses: Maybe, Necessary? 

Communication 2.
Review of Pathogenetic Aspects and Methods for Assessing the Efficiency of Anti-Radiation Agents in Experiment

A.V. Ivanchenko¹, V.A. Basharin², I.S. Drachev¹, A.B. Seleznev¹, A.Yu. Bushmanov³

¹Scientific Research Testing Institute of Military Medicine, St. Petersburg, Russia.

²S.M. Kirov Military Medical Academy, St. Petersburg, Russia.

³A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Alexander Viktorovich Ivanchenko, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Review and systematization of modern ideas about the mechanisms of the development of the effects of ionizing radiation in medium doses on a living organism in order to assess the need and possibility of using pharmaceutical agents suitable for modification purposes, about research methods in experiment; stimulation of discussion on the issue under consideration.

Results: the current understanding of the genesis of radiation effects from irradiation at medium doses in the range of 0.2-1 Gy as a subject of modification with antiradiation agents is considered.

Conclusions: The systematic nature of modern knowledge about the genesis of radiation effects from low-power irradiation in medium doses of the range 0.2-1 Gy, heterogeneity and mixing of mechanisms can be considered as a basis for the use of antiradiation agents with different properties and aimed at target (direct) and non-target (indirect) ) the effect of radiation. One of the problems of using and predicting the radioprotective efficiency of the PLC is the poor development of methods for establishing correlations between the indicators of increased radioresistance (without irradiation) with the actual antiradiation effect.

Keywords: irradiation, average doses, pathogenesis of consequences, methods of assessment in experiment, antiradiation agents, disputability of use

For citation: Ivanchenko AV, Basharin VA, Drachev IS, Seleznev AB, Bushmanov AYu. To the Question About Pharmacological Protection During Irradiation In Non-infecting Doses: Maybe, Necessary? Communication 2. Review of Pathogenetic Aspects and Methods for Assessing the Efficiency of Anti-Radiation Agents in Experiment. Medical Radiology and Radiation Safety. 2022;67(4):101-112. DOI: 10.33266/1024-6177-2022-67-4-101-112

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Contribution. Article was prepared with equal participation of the authors

Article received: 28.03.2022.  Accepted for publication: 23.05.2022