Medical Radiology and Radiation Safety. 2025. Vol. 70. № 2
DOI:10.33266/1024-6177-2025-70-2-119-125
V.A. Manukova, I.P. Aslanidis, O.V. Mukhortova,
M.V. Metelkina, I.V. Ekaeva, A.S. Rumyantsev, A.V. Silchenko
11C-Methionine and 18F-Fluorodeoxyglucose PET/CT
in Multiple Myeloma Patients – One-Day Investigation
A.N. Bakulev Scientific Center for Cardiovascular Surgery, Moscow, Russia
Contact person: V.A. Manukova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Background: To evaluate the impact of PET/СT with 11C-Methionine (MET) and 18F-fluorodeoxyglucose (FDG) on physiological distribution of FDG in patients with multiple myeloma (MM).
Material and methods: 40 patients with a history of MM were included in the analysis, 60 PET/CT exams were conducted: in the 1st group – 20 doubled PET/CT (MET PET/CT followed by FDG PET/CT); in the 2nd group – 20 FDG PET/CT.
Results: Comparative analysis of the physiological accumulation of FDG in two groups of patients with MM – one group passed one day 11C-MET PET/CT followed by 18F-FDG PET/CT and another group passed standard 18F-FDG PET/CT – revealed no statistically significant difference. SULmax and SULmean was calculated in the right lobe of the liver, in the ascending aorta and in the head of the pancreas. The mean values of liver SULmax were: in the first group – 2.37 ± 0.36, in the second group – 2.46 ± 0.40, p = 0.1. The mean values of aortic SULmax were: in the first group – 1.42 ± 0.25, in the second group – 1.51 ± 0.37, p = 0.11. The mean SULmax values in the pancreatic head were: in the first group – 1.43 ± 0.26, in the second group – 1.59 ± 0.36, p = 0.08.
Conclusion: A one-day MET and FDG PET/CT does not affect the pharmacokinetics of FDG and can be used in MM patients.
Keywords: multiple myeloma, PET/CT, 11C-Methionine, 18F-Fluorodeoxyglucose, one-day investigation
For citation: Manukova VA, Aslanidis IP, Mukhortova OV, Metelkina MV, Ekaeva IV, Rumyantsev AS, Silchenko AV. 11C-Methionine and 18F-Fluorodeoxyglucose PET/CT in Multiple Myeloma Patients – One-Day Investigation. Medical Radiology and Radiation Safety. 2025;70(2):119–125. (In Russian). DOI:10.33266/1024-6177-2025-70-2-119-125
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Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Development of the research concept and design, research methods, collection and analysis of literary material, statistical data processing, writing and scientific editing of the text – V.A. Manukova, I.P. Aslanidi, O.V. Mukhortova, M.V. Metelkina, I.V. Yekaeva, A.S. Rumyantsev, A.V. Silchenko – in equal parts.
Article received: 20.12.2024. Accepted for publication: 25.01.2025.