Medical Radiology and Radiation Safety. 2026. Vol. 71. № 3

DOI:10.33266/1024-6177-2026-71-3-30-33

E.V. Goloborodko, A.S. Kretov, D.Yu. Makarov

Non-Drug Methods of Increasing the Radioresistance (Literature Review)

A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia

Contact person:  E.V. Goloborodko, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

ABSTRACT 

Ionizing radiation poses a significant health threat, causing oxidative stress, DNA damage, and systemic inflammation. In addition to pharmacological protective measures and radioprotectors, interest in non-pharmacological strategies aimed at enhancing endogenous defenses is growing. This review systematizes current data on non-pharmacological methods for enhancing radioresistance, including diet, lifestyle modification, and the use of natural bioactive compounds. We analyze their mechanisms of action, including activation of antioxidant systems (the Nrf2 pathway), induction of DNA repair, and modulation of the immune response and microbiome. A combination of several approaches is most effective.

Keywords: radioresistance, enhancing, non-drug approaches, oxidative stress, antioxidants, calorie restriction, Nrf2, microbiome, review

For citation: Goloborodko EV, Kretov AS, Makarov DYu. Non-Drug Methods of Increasing the Radioresistance (Literature Review). Medical Radiology and Radiation Safety. 2026;71(3):30–33. DOI:10.33266/1024-6177-2026-71-3-30-33

 

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.02.2026. Accepted for publication: 25.03.2026.