Medical Radiology and Radiation Safety. 2026. Vol. 71. № 4
DOI: 10.33266/1024-6177-2026-71-4-5-11
A.K. Chigasova1, 2, 3, A.N. Osipov1, 2
ANALYSIS OF PHOSPHORYLATED HISTONE H2AX FOCI IN RADIOBIOLOGY: A LITERATURE REVIEW
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 N.N. Semenov Federal Research Center for Chemical Physics, Moscow, Russia
3 N.M. Emanuel Institute of Biochemical Physics, Moscow, Russia
Contact person: A.N. Osipov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENTS
Introduction
General characteristics of histone H2AX
Sources of spontaneous (background) γH2AX foci
Formation of γH2AX foci in irradiated cells
The influence of chromatin structure on the formation and degradation of radiation-induced γH2AX foci
The influence of cell cycle phase on the formation and degradation of radiation-induced γH2AX foci
Residual radiation-induced γH2AX foci
Conclusion
Keywords: γH2AX, DNA damage, DNA repair, ionizing radiation
For citation: Chigasova AK, Osipov AN. Analysis of Phosphorylated Histone H2ax Foci in Radiobiology: a Literature Review. Medical Radiology and Radiation Safety. 2026;71(4):5–11. DOI:10.33266/1024-6177-2026-71-4-5-11
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Conflict of interest.The authors declare no conflict of interest.
Financing. The research was carried out within the framework of the state task of the Ministry of Science and Higher Education of the Russian Federation (No. 1024122500008-3, code FFZE-2025-0030).
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.03.2026. Accepted for publication: 25.04.2026.