Medical Radiology and Radiation Safety. 2026. Vol. 71. № 4
DOI:10.33266/1024-6177-2026-71-4-92-97
D.E. Kalinkin1, 2, I.V. Milto1, 2, L.V. Smagliy1, 2, G.V. Gorina1, O.V. Litvinova1, Y.A. Samoilova3, V.А. Avkhimenko3, A.R. Takhauov1, L.R. Takhauova1, 2, R.M. Takhauov1, 2
ANALYSIS OF CANCER INCIDENCE AND MORTALITY RATES OF STAFF AT PLUTONIUM PRODUCTION OF SIBERIAN CHEMICAL PLANT
1 Seversk Biophysical Research Center, Seversk, Russia
2 Siberian State Medical University, Tomsk, Russia
3 Siberian Federal Scientific Clinical Center, Seversk, Russia
Contact person: L.V. Smagliy, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To analyze the oncological morbidity and mortality of the personnel of the plutonium production of the Siberian Chemical Plant.
Material and methods: An assessment of the indicators and standardized relative risk of oncological morbidity and mortality of the personnel of the plutonium production of the Siberian Chemical Plant was performed. Cases of malignant neoplasms and deaths due to them in the period 1950–2020 were analyzed for the personnel hired in the period 1950–2015.
Results: In the structure of oncological morbidity and mortality among plutonium production personnel in the period 1950–2020, malignant neoplasms of the digestive organs, respiratory system, urinary tract, genital organs, and mammary gland (in women) were the leading ones. Among the female personnel of the study group, the risks of developing malignant neoplasms with the corresponding total dose of external radiation (mSv) were statistically significantly increased for the digestive organs (> 0 mSv, > 20–50 mSv), respiratory system (> 0 mSv, > 0–20 mSv), skin (> 0 mSv), mammary gland (> 0 mSv, > 20–50 mSv), genitourinary organs (> 0 mSv), as well as malignant neoplasms of all localizations combined (> 0 mSv, > 20–50 mSv). In male personnel, the risk of death due to malignant neoplasms was significantly increased in the respiratory system (> 150–200 mSv and > 300–500 mSv), skin (> 20–50 mSv), and urinary tract
(> 20–50 mSv).
Male personnel in the study group also had a statistically significantly increased risk of death due to malignant neoplasms (with a corresponding total external radiation dose, mSv) of the digestive system (> 100–150 mSv and > 150–200 mSv), respiratory system (> 300–500 mSv), urinary tract (> 0 mSv, > 20–50 mSv), and genitals (> 0 mSv and > 300–500 mSv). Among female personnel – digestive organs (> 0 mSv, > 20–50 mSv), respiration (> 0 mSv, > 0–20 mSv), mammary glands (> 0 mSv, > 20–50 mSv), genital organs (> 0 mSv) and all localizations combined (> 0 mSv, > 20–50 mSv).
Conclusion: Male personnel are characterized by an increased risk of developing malignant neoplasms at doses above 150 mSv (for the respiratory system) and mortality due to malignant neoplasms at doses above 300 mSv (for the respiratory system) and at doses above 150 mSv (for the digestive system). For all other identified malignant neoplasm sites in men, as well as in women, the increased risks of morbidity and mortality are predominantly in the range of up to 50 mSv.
Keywords: personnel, plutonium production, new types of nuclear fuel, malignant neoplasms, morbidity, mortality
For citation: Kalinkin DE, Milto IV, Smagliy LV, Gorina GV, Litvinova OV, Samoilova YA, Avkhimenko VА, Takhauov AR, Takhauova LR, Takhauov RM. Analysis of Cancer Incidence and Mortality Rates of Staff at Plutonium Production of Siberian Chemical Plant. Medical Radiology and Radiation Safety. 2026;71(4):92–97. DOI:10.33266/1024-6177-2026-71-4-92-97
References
1. Diakov A. The History of Plutonium Production in Russia. Science & Global Security. 2011;19:28-45. Doi: 10.1080/08929882.2011.566459.
2. Иванов С.Б. Ядерный оружейный комплекс. Оружие и технологии России. Энциклопедия XXI века. М.: Оружие и технологии, 2007. 672 c. [Ivanov S.B. Yadernyy Oruzheynyy Kompleks. Oruzhiye i Tekhnologii Rossii. Entsiklopediya XXI veka = Nuclear Weapons Complex. Weapons and Technologies of Russia. Encyclopedia of the 21st Century. Moscow, Oruzhiye i Tekhnologii Publ., 2007. 672 p. (In Russ.)].
3. Отчёт по экологической безопасности АО «СХК». Северск: Сибирский химический комбинат, 2021. 40 c. [Otchet po Ekologicheskoy Bezopasnosti AO «SKHK» = Environmental Safety Report of JSC Siberian Chemical Combine. Seversk, Sibirskiy Khimicheskiy Kombinat Publ., 2021. 40 p. (In Russ.)].
4. Паринов О.В., Семенова М.П., Шандала Н.К., Лягинская А.М., Метляев Е.Г., Купцов В.В., Богданов И.И. Современные представления о радиобиологических эффектах плутония и урана (по материалам 150-й публикации МКРЗ) // Гигиена и санитария. 2023. Т.102. №2. С. 175-180 [Parinov O.V., Semenova M.P., Shandala N.K., Lyaginskaya A.M., Metlyayev Ye.G., Kuptsov V.V., Bogdanov I.I. Modern Concepts of the Radiobiological Effects of Plutonium and Uranium (Based on the 150th Publication of the ICRP). Gigiyena i Sanitariya = Hygiene and Sanitation. 2023;102;2:175-180 (In Russ.)]. Doi: 10.47470/0016-9900-2023-102-2-175-180.
5. ICRP Publication. Cancer Risk from Exposure to Plutonium and Uranium. Ann. ICRP. 2020;50;4:150.
6. Omar R.Z., Barber J.A., Smith P.G. Cancer Mortality and Morbidity among Plutonium Workers at the Sellafield Plant of British Nuclear Fuels.
Br J Cancer. 1999;79;7-8:1288-1301. Doi: 10.1038/sj.bjc.6690207.
7. Gillies M., Kuznetsova I., Sokolnikov M., Haylock R., O’Hagan J., Tsareva Y., Labutina E. Lung Cancer Risk from Plutonium: a Pooled Analysis of the Mayak and Sellafield Worker Cohorts. Radiat Res. 2017;188;6:645-660. Doi: 10.1667/RR14719.1.
8. Brown S.C., Schonbeck M.F., McClure D., Barón A.E., Navidi W.C., Byers T., Ruttenber A.J. Lung Cancer and Internal Lung Doses Among Plutonium Workers at the Rocky Flats Plant: Case Control Study. Am J Epidemiol. 2004;160:163-172. Doi: 10.1093/aje/kwh192.
9. Sokolnikov M., Preston D., Stram D.O. Mortality from Solid Cancers other than Lung, Liver, and Bone in Relation to External Dose Among Plutonium and Non-Plutonium Workers in the Mayak Worker Cohort. Radiat Environ Biophys. 2017;56;1:121-125. Doi: 10.1007/s00411-016-0670-5.
10. Ильин Л.А., Самойлов А.С., Цовьянов А.Г., Шинкарев С.М., Шандала Н.К., Ганцовский П.П., Карев А.Е., Кухта Б.А., Симаков А.В., Клочков В.Н., Коренков И.П., Лягинская А.М., Паринов О.В., Соломатин В.М., Изместьев К.М. Радиационно-гигиенические исследования экспериментального производства смешанного нитридного уран-плутониевого топлива на АО «СХК». Часть 1: Методы и результаты // Медицинская радиология и радиационная безопасность. 2021. Т.66. № 5. С. 23-32 [Il’in L.A., Samoylov A.S., Tsov’yanov A.G., Shinkarev S.M., Shandala N.K., Gantsovskiy P.P., Karev A.Ye., Kukhta B.A., Simakov A.V., Klochkov V.N., Koren’kov I.P., Lyaginskaya A.M., Parinov O.V., Solomatin V.M., Izmest’yev K.M. Radiation and Hygienic Studies of the Experimental Production of Mixed Nitride Uranium-Plutonium Fuel at JSC SCC. Part 1: Methods and Results. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2021;66;5:23-32 (In Russ.)]. Doi: 10.12737/1024-6177-2021-66-5-23-32.
11. Ильин Л.А., Самойлов А.С., Цовьянов А.Г., Шинкарев С.М., Шандала Н.К., Ганцовский П.П., Карев А.Е., Кухта Б.А., Симаков А.В., Клочков В.Н., Коренков И.П., Лягинская А.М., Паринов О.В., Иванов В.К., Чекин С.Ю., Меняйло А.Н., Туманов К.А., Соломатин В.М., Изместьев К.М. Радиационно-гигиенические исследования экспериментального производства смешанного нитридного уран-плутониевого топлива на АО «СХК». Часть 2: Дозы и риски // Медицинская радиология и радиационная безопасность. 2022. Т. 67, № 1. С. 39-45 [Il’in L.A., Samoylov A.S., Tsov’yanov A.G., Shinkarev S.M., Shandala N.K., Gantsovskiy P.P., Karev A.Ye., Kukhta B.A., Simakov A.V., Klochkov V.N., Koren’kov I.P., Lyaginskaya A.O., Parinov O.V., Ivanov V.K., Chekin S.Yu., Menyaylo A.N., Tumanov K.A., Solomatin V.M., Izmest’yev K.M. Radiation and Hygienic Studies of the Experimental Production of Mixed Nitride Uranium-Plutonium Fuel at JSC Siberian Chemical Combine. Part 2: Doses and Risks. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost’ = Medical Radiology and Radiation Safety. 2022;67;1:39-45
(In Russ.)]. Doi: 10.12737/1024-6177-2022-67-1-39-45.
12. Ahlbom A., Norell S. Introduction to Modern Epidemiology. Second Edition. Chestnut Hill, Epidemiology Resources Inc, 1990. 222 p.
13. Sokolnikov M., Preston D., Gilbert E., Schonfeld S., Koshurnikova N. Radiation Effects on Mortality from Solid Cancers other than Lung, Liver, and Bone Cancer in the Mayak Worker Cohort: 1948-2008. PLoS One. 2015;10;2:e0117784. Doi: 10.1371/journal.pone.0117784.
14. Krestinina L.Y., Preston D., Ostroumova E., Degteva M.O., Ron E., Vyushkova O.V., Startsev N.V., Kossenko M.M., Akleyev A.V. Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort. Radiat Res. 2005;164;5:602-611. Doi: 10.1088/0952-4746/19/1/002.
15. Schonfeld S.J., Krestinina L.Y., Epifanova S., Degteva M.O., Akleyev A.V., Preston D.L. Solid Cancer Mortality in the Techa River Cohort (1950-2007). Radiat Res. 2013;179;2:183-189. Doi: 10.1667/RR2932.1.
16. Muirhead C.R., Goodill A.A., Haylock R.G., Vokes J., Little M.P., Jackson D.A., O’Hagan J.A., Thomas J.M., Kendall G.M., Silk T.J., Bingham D., Berridge G.L. Occupational Radiation Exposure and Mortality: Second Analysis of the National Registry for Radiation Workers. J Radiol Prot. 1999;19;1:3-26. Doi: 10.1088/0952-4746/19/1/002.
17. Voelz G.L., Lawrence J.N.P., Johnson E.R. Fifty Years of Plutonium Exposure to the Manhattan Project Plutonium Workers: an Update. Health Phys. 1997;73:611-619. Doi: 10.1097/ 00004032-199710000-00004.
18. Wing S., Richardson D., Wolf S., Mihlan G. Plutonium-Related Work and Cause-Specific Mortality at the United Sates Department of Energy Hanford Site. Am J Ind Med. 2004;45:153-164. Doi: 10.1002/ajim.10332.
19. Gilbert E.S., Koshurnikova N.A., Sokolnikov M.E., Shilnikova N.S., Preston D.L., Ron E., Okatenko P.V., Khokhryakov V.F., Vasilenko E.K., Miller S., Eckerman K., Romanov S.A. Lung Cancer in Mayak Workers. Radiat Res. 2004;162:505-516. Doi: 10.1667/rr3259.
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Conflict of interest.The authors declare no conflict of interest.
Financing. The study was carried out as part of the Federal Target Program “Ensuring Nuclear and Radiation Safety for 2016-2020 and for the period up to 2035”.
Contribution. Research concept and design: Kalinkin D.E., Avkhimenko V.A., Takhaouov R.M.; data collection: Samoilova Yu.A., Gorina G.V., Litvinova O.V., Takhaouov A.R., Takhaouova L.R.; analysis and interpretation of results: Kalinkin D.E., Smagliy L.V.; literature review: Smagliy L.V.; manuscript preparation: Kalinkin D.E., Milto I.V. All authors reviewed the results and approved the final version of the manuscript.
Article received: 20.03.2026. Accepted for publication: 25.04.2026.