Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 5-11

RADIATION BIOLOGY

A.A. Ivanov^1,2, I.E. Andrianova¹, T.M. Bulynina^1,2, O.V. Dorozhkina^1,2, V.N. Mal’tsev¹, N.M. Stavrakova¹, G.A. Shal’nova¹, A.Yu. Bushmanov¹

The Pharmacological Effects of Melanin in the Irradiated Mice

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Joint Institute for Nuclear Research, Dubna, Russia

ABSTRACT

Purpose: Investigation of the melanin efficiency administered to mice after irradiation at different doses.

Material and methods: The bone marrow form of the acute radiation syndrome in mice CD-1 was reconstructed by single or fractionated whole body irradiation with gamma- or X-rays. Phytomelanin water-soluble was given with water ad libitum from the first to the 30-th day after irradiation.

Results: It was shown that melanin was given after the acute exposure to ionizing radiation in doses 6.0-7.5 Gy decreased the lethal outcomes in all groups of mice. The survival melanin treated mice increased by 13-18 % as compared with control. After fractionated exposure (1 Gy daily, total dose 10 Gy) melanin produced 100 % therapeutic effect when the survival of control mice was 43.7 %. Melanin treated mice has demonstrated that body weight loss and the frequency test for bacteriuria were lower than in control. Moreover in mice which received melanin a more pronounced restoration motoric and searching activity had been observed.

Conclusion: According our experimental data melanin given “per os” after irradiation produced a marked therapeutic effect.

Key words: phytomelanin, X-rays and gamma-irradiation, single and fractionated, survival, bacteriuria, behavioral reactions, experimental therapy

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For citation: Ivanov AA, Andrianova IE, Bulynina TM, Dorozhkina OV, Mal’tsev VN, Stavrakova NM, Shal’nova GA, Bushmanov AYu. The Pharmacological Effects of Melanin in the Irradiated Mice. Medical Radiology and Radiation Safety. 2015;60(5):5-11. Russian.

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