Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 4. P. 58-66
NUCLEAR MEDICINE
N.S. Bozhko1, S.U. Antropov1, S.V. Korostin1, G.E. Kodina2, A.O. Malysheva2
Accuracy of Measurements of Radiochemical Purity of Radiopharmaceuticals with Chromatogramm Scanner
1. STC Amplituda Ltd, Mendeleevo, Moscow region, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia
ABSTRACT
Purpose: Determination of the main sources of uncertainty occurred during measurements of radiopharmaceutical’s radiochemical purity. Calculate acceptable uncertainty levels on basis of specific normalization and method features.
Material and methods: Several samples of different radiopharmaceuticals are scanned with Gamma-Scan 01A chromatogram-scanner. Obtained chromatograms are processed for calculations of radiochemical purity and radiochemical impurities. Uncertainty budget and contribution of counting uncertainty is defined.
Results: Main guidelines for performing suitable radiochemical purity measurements and proper results interpretation are given and could be used in quality control. Required accuracy characteristics of measuring equipment are defined.
Key words: radiopharmaceuticals, radiochemical purity, gamma-chromatography, measurement uncertainly