Medical Radiology and Radiation Safety. 2013. Vol. 58. No. 2. P. 69-78


A.B. Bludov, Ya.A. Zamogilnaya, A.S. Nered, S.V. Shiryaev, N.V. Kochergina, L.E. Rotobelskaya

Diagnostic Value of Radionuclide Bone Scans in the Evaluation of the Preoperative Chemotherapy of Bone Sarcomas

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: To determine the diagnostic value of the radionuclide bone scans in the evaluation of the effectiveness of preoperative chemotherapy in patients with bone sarcomas on different diagnostic stages.

Material and methods: We analyzed the data of 52 patients with bone sarcomas (mostly with osteosarcoma (50 patients), which composed 96 % of the cases). All patients underwent bone scan examination with 99mTc-Technefor. The patients were examined before, in the middle and at the end of the preoperative chemotherapy course.

Results: The sensitivity (predilection of Grade III–IV pathologic response) of the radionuclide bone scans in the middle of the preoperative chemotherapy (after 2–3 cycles) was 87 %, the specificity (predilection of Grade I-II pathologic response) was 69 %, accuracy – 79 %. At the end of the preoperative treatment, on the second diagnostic stage, the values of the sensitivity, specificity and accuracy increased up to 90, 73 and 83 %, correspondingly.

Conclusion: Bone radionuclide bone scans with 99mTc-Tehnefor is a highly effective method in assessing of preoperative chemotherapy in patients with bone sarcomas.

Key words: osteosarcoma, chemotherapy, bone scintigraphy, 99mTc-Technefor