Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 5. P. 54-57

NUCLEAR MEDICINE

Yu.B. Lishmanov¹, N.G. Krivonogov¹, T.S. Ageeva², K.V. Zavadovskiy¹, A.V. Dubodelova²

Scintigraphic Peculiariries of Lung Affection in Case of Bronchial Asthma

1. Institute of Cardiology of Tomsk Research Center of the RAMS, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Siberian State Medical University, Tomsk, Russia

Abstract

Purpose: To determine typical scintigraphic signs of ventilationperfusion disorders for bronchial asthma. Material and methods: 20 patients with the verified diagnosis of bronchial asthma at the stage of remission and 10 healthy non-smoking volunteers took part in the study. All the examined subjects underwent ventilation-perfusion lung scintigraphy.

Results: Bronchial asthma patients have positive bilateral increase of the apical-basal gradient of perfusion, reduction of the apical-basal gradient of ventilation and acceleration of alveolar-capillary permeability during the 30th minute of the study as compared to the analogues rates of healthy individuals.

Conclusion: The data received testify to the fact that the scintigraphic assessment of alveolar-capillary permeability of lungs as well as the evaluation of apical-basal gradients of ventilation and perfusion can be used as additional criteria to diagnose bronchial asthma at early stages.

Key words: ventilation-perfusion lung scintigraphy, bronchial asthma, apical-basal gradient of perfusion and ventilation, alveolar-capillary permeability