Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 5. P. 58-65
NUCLEAR MEDICINE
V.D. Zavadovskaya, A.P. Kourazhov, O.Yu. Kilina, I.E. Gerbek, Z.A.Mayevskaya, M.A. Zorkaltsev
199Tl-Chloride-Scintigraphy in Diagnostics of Neoplastic Processes in Lungs and Mediastinum
Siberian State Medical University, Tomsk, Russia, e-mail This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Assessment of 199Tl-chloride scintigraphy efficiency in diagnostics of lungs and mediastinum neoplastic processes.
Material and methods: Patients with lungs and mediastinum tumors or inflammations were undergone 199Tl-chloride scintigraphy in early and delayed phases (15 males and 17 females, 33 localizations).
Results: Sensitivity, specificity, positive and negative predictive values and accuracy in the nonspecific indications of the tumor processes were 77.3, 63.6, 81.0, 58.3 and 72.7 %, respectively. Causes of the false negative results were tumors less 2 cm or some histological types of them. Specificity of this method in diagnostics of tumors was increased by the quantitative criteria of RI > –0.199(ER)+1.169. In total, sensitivity, specificity, positive and negative predictive values, and accuracy of the tumor diagnostics in lung and mediastinum were 77.3, 100, 100, 68.8 and 84.8 %, respectively.
Conclusion: 199Tl-chloride scintigraphy may be used successfully for indication of lung and mediastinum tumors of more than 2 cm size. The specificity of 199Tl-chloride scintigraphy was increased by considering the different pharmacokinetics of this marker in the tumor and inflammatory focuses.
Key words: 199Tl-chloride scintigraphy, neoplastic processes, retention index, radionuclide diagnostics, diagnostic efficiency