Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 53–57

RADIATION PHYSICS, TECHNOLOGY AND DOSIMETRY

DOI: 10.12737/article_5c55fb4d218e20.76419134

A.V. Belousov¹, M.V. Zheltonozhskaya^1,2, E.N. Lykova^1,2, P.D. Remisov¹, A.P. Chernyaev^1,2, V.N. Iatsenko³

Research of ¹³¹Cs Radionuclide Production for Brachytherapy with Photonuclear Method

1. Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ;
2. D.V. Skobeltsyn Institute of Nuclear Physics of M.V. Lomonosov Moscow State University, Moscow, Russia;
3. A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

A.V. Belousov – Assoc. Prof., PhD Phys.-Math.;
M.V. Zheltonozhskaya – Senior Researcher, Leading Engineer, PhD Tech.;
E.N. Lykova – Senior Lecturer, Leading Engineer; P.D. Remisov – Past-Graduate Student;
A.P. Chernyaev – Head of Dep., Head of Lab., Dr. Sci. Phys.-Math., Prof.;
V.N. Iatsenko – Head of Lab., PhD Tech.

Abstract

Purpose: Currently a brachytherapy method with ¹²⁵I received widespread acceptance in the treatment of prostate cancer. However, since 2003, ¹³¹Cs radio-implants have been approved for clinical use in the treatment of this type of cancer. To investigate alternative ¹³¹Cs receiving channels using electron accelerators and to evaluate the effectiveness of this method for its use in brachytherapy.

Material and methods: To study alternative channels for the ¹³¹Cs production using electron accelerators and to evaluate the efficiency of this method, we irradiated the natural cesium target (0.35 g) on a pulsed microtron with an electron energy of 55 MeV, an average amperage of 40–45 nA during 80 min.

Results: The ¹³¹Cs activity in the irradiated sample was 12.2 ± 1.0 μCi at the end of irradiation.

Conclusion: In brachytherapy, 10 to 60 micro-sources are usually used to treat a patient. The activity of one therapeutic micro source is ¹³¹Cs of the order of 10^–3 Ci. Thus, the development of the required amount becomes possible when using electron accelerators with currents of the order of 50 mA. In the future it is also necessary to investigate ¹³¹Cs in the electron energy range 30–45 MeV for choosing the optimal irradiation regime.

Key words: medical physics, brachytherapy, activation, electron accelerators, photonuclear reactions, ¹³¹Cs

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For citation: Belousov AV, Zheltonozhskaya MV, Lykova EN, Remisov PD, Chernyaev AP, Iatsenko VN. Research of ¹³¹Cs Radionuclide Production for Brachytherapy with Photonuclear Method. Medical Radiology and Radiation Safety. 2019;64(1):53-7. (Russian).

DOI: 10.12737/article_5c55fb4d218e20.76419134

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