Medical Radiology and Radiation Safety. 2021. Vol. 66. № 6. P. 34–38

Influence of Drinking Water Quality on the Current of Acute Radiation Disease in Mice

Bychkova T.M.1,2, Andrianova I.E.1, Nikitenko O.V.1,2, Stavrakova N.M.1, Parfenova I.M.1, Karaulova T.A.1, Gordeev A.V.1, Ivanov A.A.1,2,3

1A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

2RFSSC Institute of Biomedical Problems, Moscow, Russia

3Joint Institute for Nuclear Research, Dubna, Russia

Contact person: Taisia Mikhailovna Bychkova: This email address is being protected from spambots. You need JavaScript enabled to view it.  


Purpose: Assessing the role of various factors in the formation of radioresistance is an important branch of radiobiology. The quality of drinking water, as it turned out, can significantly affect radioresistance. Against the background of studying the antiradiation properties of various types of water, differing in mineral and isotopic composition, the problem of the influence of tap water on the course of radiation injury remained underestimated. This circumstance determined the purpose of the work: to evaluate the modifying effect of tap water on the course of acute radiation sickness after X-ray irradiation of mice at an average lethal dose. 

Material and methods: Female ICR (CD-1) mice were irradiated with an average lethal dose once – 6.5 Gy of X-ray irradiation. After irradiation, half of the mice received tap water as drinking water, and the other half received artificially mineralized drinking water.

Results: Keeping animals on tap water significantly reduced the survival rate of mice both with a single dose (log-rank test p=0.02, χ2=5.38) compared with animals receiving artificially mineralized distilled water. In addition, in the group of mice that received tap water, an increase in the rate of death of mice and a lower preservation of the group mass of animals during the development of acute radiation injury was noted. 

Conclusion: Tap water, used as drinking water, increases the damaging effect of radiation when X-rays are irradiated in mice.

Key words: tap water, artificially mineralized distilled water, X-ray irradiation, survival rate, mortality rate, mice, model

For citation: Bychkova TM, Andrianova IE, Nikitenko OV, Stavrakova NM, Parfenova IM, Karaulova TA, Gordeev AV, Ivanov AA. Influence of Drinking Water Quality on the Current of Acute Radiation Disease in Mice. Medical Radiology and Radiation Safety. 2021;66(6):34–38.

DOI: 10.12737/1024-6177-2021-66-6-34-38


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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 10.08.2021

Accepted for publication: 21.09.2021