Medical Radiology and Radiation Safety. 2016. Vol. 61.  No. 6. P. 57-63

RADIATION THERAPY

S.S. Gordeyev, V.A. Ivanov, A.O. Rasulov, Yu.A. Barsukov, S.I. Tkachev, Yu.E. Surayeva, M.V. Chernykh, D.V. Kuzmichev, E.N. Kozak, A.G. Malikhov, J.M. Madyarov

Chemoradiotherapy in Complicated Locally Advanced or Recurrent Rectal Cancer Treatment

N.N. Blokhin Russian Cancer Research Center of RAMS, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To investigate the toxicity and feasibility of chemoradiotherapy in patients with complicated locally advanced or recurrent rectal cancer.

Material and methods: Patients who received chemoradiotherapy during 2005–2015 for locally advanced or recurrent rectal cancer with fistulas and/or peritumoral abscesses were included in a retrospective analysis. The control group consisted of patients with uncomplicated мsub>4N_xM₀ rectal cancer. Endpoints included chemoradiotherapy toxicity, R0 resections rate, postoperative morbidity, pathologic complete response rate.

Results: Grade 3-4 toxicity was recorded in 3 (14.3 %) patients in both groups (study group G4 in 1 patient and G3 in 2 patients, control group G3 in 3 patients, p = 0.267). No difference in the incidence of complications of chemoradiotherapy between groups were observed (p = 0,267). Postoperative complications Grade IIIb in the study group occurred in 1 patient (5.5 %), and in 1 patient in the control group (5.5 %). Overall morbidity was similar in both groups (p = 0.293). R₀ resection was intended in 18 patients in both groups and performed in 16 (88.8 %) patients in the study group and in 18 (100 %) in control group. pCR was observed in 3 patients in the study group (17.6 %) and in 1 patient (5,2 %) in control group, p = 0,137.

Conclusion: chemoradiotherapy in patients with complicated locally advanced cancer does not lead to a significant increase in toxicity, allowing R₀ resection to be performed to the majority of patients after treatment without increase in morbidity.

Key words: rectal cancer, complicated, fistula, chemoradiotherapy, toxicity

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For citation: Gordeyev SS, Ivanov VA, Rasulov AO, Barsukov YuA, Tkachev SI, Surayeva YuE, Chernykh MV, Kuzmichev DV, Kozak EN, Malikhov AG, Madyarov JM. Chemoradiotherapy in Complicated Locally Advanced or Recurrent Rectal Cancer Treatment. Medical Radiology and Radiation Safety. 2016;61(6):57-63. Russian.

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