Medical Radiology and Radiation Safety, 2016, Vol. 61. No. 5. P. 13-26


V. Azizova1, E.S. Grigoryeva1, R. Haylock2, M.V. Bannikova1, M.B. Moseeva1

Risk of Incidence and Mortality from Ischemic Heart Disease in the Cohort of Workers with Chronic Occupational Exposure

1. Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Public Health England, Chilton, UK


Purpose: Assessment of incidence and mortality risk from ischemic heart disease (IHD) in relation to radiation (external gamma- and internal alpha-exposure) and non-radiation factors (gender, age, smoking, alcohol consumption, hypertension, increased body mass index).

Material and methods: IHD risk was studied in the cohort of workers of the nuclear enterprise (22377 workers, 25 % - females) with chronic occupational exposure. Relative risks and excess relative risks per unit dose (1 Gray) were calculated based on maximum likelihood using AMFIT module of the EPICURE software. Dose estimates used in analyses were provided by an updated ‘Mayak Worker Dosimetry System-2008’.

Results: A significant linear association of IHD incidence risk with total dose from external gamma-rays was observed after having adjusted for non-radiation factors and dose from internal radiation (ERR/Gy = 0.10; 95 % CI: 0.04, 0.17). No significant association of IHD mortality risk was revealed after having adjusted for non-radiation factors and dose from internal alpha-radiation (ERR/Gy = 0.06; 95 % CI: < 0, 0.15). No association of IHD incidence risk with total absorbed dose from internal alpha-radiation to the liver after having adjusted for non-radiation factors and external gamma-dose (ERR/Gy = 0.02; 95 % CI: n/a, 0,10). Statistically significant linear association of IHD mortality risk with total absorbed dose from internal alpha-radiation to the liver was revealed after having adjusted for non-radiation factors and external gamma-dose (ERR/Gy = 0.21; 95 % CI: 0.01, 0.58).

Conclusion: This study provides strong evidence of the association of the ischemic heart disease incidence risk with external gamma-ray exposure and some evidence of the association of the mortality risk for ischemic heart disease with internal alpha-radiation exposure.

Key words: risk, mortality, incidence, ischemic heart disease, Mayak PA, gamma-ray, alpha-radiation, occupational exposure


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For citation: Azizova TV, Grigoryeva ES, Haylock R, Bannikova MV, Moseeva MB. The Risk of Incidence and Mortality from Ischemic Heart Disease in the Cohort of Workers with Chronic Occupational Exposure. Medical Radiology and Radiation Safety. 2016;61(5):13-26. Russian.

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