Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 31-39

RADIATION EPIDEMIOLOGY

E.I. Rabinovich, V.F. Obesnyuk, S.V. Povolotskaja, S.N. Sokolova, V.A. Turdakova

Impact Assessment of Carcinogenic Factors on the Atrophic Gastritis in the Cohort of Workers of the Nuclear Facility

Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: Research of exogenous and endogenous risk factors of atrophic gastritis (AG) appearing among the workers of atomic enterprise “Mayak”.

Material and methods: 542 individuals were enrolled into research, 438 of them are workers of “Mayak”. The main health hazards for the “Mayak” personnel are possible long-term external γ-exposure and (or) internal exposure with α-particles, as well as the effects of ecotoxic chemicals. The control group consisted of 104 individuals never exposed to any occupational factors. Functional status of the stomach was investigated by GastroPanel test-system (Biohit, Finland). Assessment of statistical significance of the differences was performed on χ² statistics calculating the p-value as well as applying contingency tables with further calculations of relative risk.

Results and conclusions: According to the results the incidence of atrophic gastritis among Mayak PA workers exceeded those among the individuals never exposed to harmful occupational factors (14.8 % against 4.8 %; p < 0.05). Statistical analysis showed that both occupational and non-occupational factors affect the development of AG. Thus, a significant increase of relative risk of atrophic gastritis was stated in relation to external exposure with doses equal to 150 mGy and higher (RR = 3.62, 90 % CI 1.53-9.12) in relation to influence of inorganic compounds (RR = 1.58 , 90 % CI 1.04-2.33). Family anamnesis of stomach cancer (RR = 2.27, 90 % CI 1.29-3.57), non-ulcerous gastritis (RR = 1.68, 90 % CI 1.08-2.5), female gender (RR = 1.53, 90 % CI 1.05-2.21) had predisposing influence on development of AG. At the same time a statistically significant deterrent effects for development of AG was detected for smoking factor (RR = 0.51, 90 % CI 0.31-0.78). The data obtained are of great importance, and the question on purposeful detection of AG among the workers exposed to occupational radiation and chemical factors arises. Taking into account the effects of non-occupational carcinogenic factors an elaboration of an individual program of cancer prevention appears.

Key words: radiation exposure, carcinogenic factors, gastric cancer, atrophic gastritis, “Gastro Panel”

REFERENCES

1. Merabishvili V.M. Analiticheskaya epidemiologiya raka zheludka. Voprosy onkologii. 2013. Vol. 59. No. 5. P. 565-570. (In Russ.).
2. Forman D., Burley V.J. Gastric cancer: global pattern of the disease and an overview of enviromental risk factors. Best. Pract. Res. Clin. Gastroenterol. 2006. Vol. 20. No. 4. P. 633-649.
3. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. FACSAL on CEP. Cancer Res. 1992. Vol. 52. P. 6735-6742.
4. Sipponen P., Kekki M., Haapakoski J. et al. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int. J. Cancer. 1985. Vol. 35. P. 173-177.
5. Koshurnikova N.A., Okatenko P.V., Fomin E.P. et al. Nekotorye pokazateli zabolevaemosti i smertnosti ot zlokachestvennykh novoobrazovanii sredi naseleniya Ozerska za period s 1994 po 2004 gg. Meditsina ekstrem. situatsii. 2006. No. 4 .P. 30-40. (In Russ.)
6. Kabasheva N.Ya. Kliniko-morfologicheskaya kharakteristika zabolevanii zheludka u bol'nykh khronicheskoi luchevoi bolezn'yu v otdalennom periode i u rabotnikov radiokhimicheskogo proizvodstva. Moscow: Diss. kand. med. nauk.1984.153 p. (In Russ.)
7. Vaananen Kh., Vaukhkonen M., Khelske T. et al. Neendoskopicheskaya diagnostika atroficheskogo gastrita na osnovanii analiza krovi: korrelyatsiya mezhdu rezul'tatami gistologicheskogo issledovaniya zheludka i urovnyami gastrina-17 i pepsinogena-1 v syvorotke. Klin. persp. gastroenter. gepatol. 2003. No. 4. P. 26-32. (In Russ.)
8. Miki K., Fujishiro M., Kodashima S., Yahagi N. Longterm results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population. Dig. Endosc. 2009. Vol. 21. No. 2. P. 78-81.
9. Jolliffe I.T. Principal Component Analysis. 2^nd New York: Springer. 2002. 487 p.
10. Obesnyuk V.F., Khromov-Borisov N.N. Interval'nye otsenki pokazatelei sravnitel'nogo mediko-biologicheskogo issledovaniya. V. sb. nauchnykh trudov 10-i mezhvuz. mezhdunar. Telekonferentsii «Aktual'nye problemy sovremennoi nauki». Tomsk. 2013. Vol. 2. No. 1. P. 154-156.
11. Upton G.J.G. The Analysis of Cross-tabulated Data. New York: John Wiley and Sons. 1978. 160 p.
12. Epidemiologicheskii slovar'. In: Dzh. M. Lasta (ed.). Moscow: OIZ. 2009. 316 p. (In Russ.)
13. Pravila proverki soglasiya opytnogo raspredeleniya s teoreticheskim. Chast' 1. Rekomendatsii po standartizatsii: R 50.1.033-2001. Moscow: Gosstandart Rossii. 2002. 174 p. (In Russ.)
14. Elashov J.D., Lemeshow S. Sample size determination in epidemiologic studies In Handbook of Epidemiology. Ed. By W. Ahrens, I. Pigeot. Springer, 2004.P. 559-594.
15. Khokhryakov V.V., Khokhryakov V.F., Suslova K.G. et al. Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of internal alpha-dose from measurement results of plutonium activity in urine. Health Phys. 2013. Vol. 104. No. 4. P. 366-378.
16. Leont'eva N.I., Gracheva N.M., Novikova L.I. Klinicheskaya otsenka diagnostiki khelikobakterioza u bol'nykh s khronicheskoi patologiei zheludochno-kishechnogo trakta diagnosticheskoi test-sistemoi «Gastro Panel. Eksperim. klin. gastroenterol. 2009. No. 2. Supp. 1. P. 80. (In Russ.)
17. Tsukanov V.V., Tret'yakova O.V., Amel'chugova O.S. et al. Rasprostranennost' atroficheskogo gastrita tela zheludka u naseleniya g. Krasnoyarska starshe 45 let. RZhGGK,.2012. Vol. 22. No. 4. P. 27-31. (In Russ.)
18. Kuwahara Y., KonoS., Eguchi H. et al. Relationship between serologically diagnosed chronic atrophic gastritis, H. pylori and environmental factors in Japanese men. Scand. Gastroenterology. 2000. Vol. 35. No. 5. P. 476-481.
19. Dorn O.Yu., Peskov S.A., Poteryaeva E.L. et al. Faktory riska v razvitii gastropatii u rabochikh pyleopasnykh professii. Meditsina truda i prom. ekologiya. 2011. No. 2. P. 23-27. (In Russ.)
20. Rapoport S.I. Gastrity. Posobie dlya vrachei. Moscow: Medpraktika. 2010. 19 p. (In Russ.)
21. Hishida A., Matsuo K., Goto Y., Hamajima N. Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. World J. Gastrointest. Oncol. 2010. Vol. 2. No. 10. P. 369-379.
22. Sun L.P., Guo X.L., Zhang Y. et al. Impact of pepsinogen Ϡpolimorfism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population. J. Cancer Res. Oncol. 2009. Vol. 135. P. 1033-1039.
23. Effects of Ionizing Radiation. UNSCEAR 2006 Report. 1A. New York: United Nations Publication. 2008. 383 p.
24. Bonney G.E., Elston R.C., Correa P. et al. Genetic etiology of gastric carcinoma: 1. Chronic atrophic gastritis. Genet. Epidemiol. 1986. Vol. 3. No. 4. P. 213-214.
25. Muszyński J., Biernacka D., Siemińska J. et al. Effect of age and sex on the occurrence of gastritis changes in gastric mucosa. Pol. Med. Wewn. 1996. Vol. 95. No. 6. P. 542-548.
26. Tokui N., Nishisaka S., Mizoue T. et al. A sero-epidemiological study on atrophic gastritis and Helicobacter pylori infection. JUOEN. 1996. Vol. 18. No. 2. P. 133-140.
27. Risk factors for atrophic chronic gastritis in a European population: results of the Eurohepygast study. The Eurohepygast Study Group. Gut. 2002. Vol. 50.P. 779-785.
28. Hishida A., Matsuo K., Goto Y. et. al. Smoking behavior and risk ̥licobacter pylori infection, gastric atrophy and gastric cancer in Japanese. Asian. J. Cancer Prev. 2010. Vol. 11. No. 2. P. 313-317.
29. Parente F., Lazzaroni M., Sangaletti O. et al. Cigarette smoking, gastric acid secretion and serum pepsinogen-1 concentration in duodenal ulcer patients. Gut. 1985. Vol. 26. No. 12. P. 1327-1332.
30. Pomytkina T.E. Soderzhanie gastrina-17 i pepsinogena-1 v syvorotke krovi bol'nykh yazvennoi bolezn'yu dvenadtsatiperstnoi kishki pri proizvodstvennom kontakte s azotistymi soedineniyami. Klinich. laborator. diagnostika. 2009. No. 311.P. 16-19. (In Russ.)
31. SanPin 2.6.1.2523-09. Normy radiatsionnoi bezopasnosti NRB-99/2009. Utverzhdeny postanovleniem glavnogo gosudarstvennogo sanitarnogo vracha RF ot 7.07.2009. (In Russ.)

For citation: Rabinovich EI, Obesnyuk VF, Povolotskaja SV, Sokolova SN, Turdakova V.A. Impact Assessment of Carcinogenic Factors on the Atrophic Gastritis in the Cohort of Workers of the Nuclear Facility. Medical Radiology and Radiation Safety. 2015;60(5):31-9. Russian.

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